Patents by Inventor Leander Huyghe

Leander Huyghe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC TARGETING OF NON-CELLULAR STRUCTURES
    Publication number: 20240025980
    Abstract: The present invention relates, in part, to chimeric proteins that bind a non-cellular structure and their use as therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the chimeric proteins and their use in the treatment of various diseases.
    Type: Application
    Filed: July 20, 2023
    Publication date: January 25, 2024
    Inventors: Nikolai KLEY, Jan TAVERNIER, Leander HUYGHE, Anje CAUWELS
  • BI-FUNCTIONAL CHIMERIC PROTEINS AND USES THEREOF
    Publication number: 20230287131
    Abstract: The present invention relates, in part, to targeted chimeric proteins with beneficial therapeutic effects, including, for example, effects mediated by mutant forms of soluble agents that are part of the chimeric proteins. Pharmaceutical compositions comprising the chimeric proteins are also provided. The present invention finds use in the treatment of various disease and disorders.
    Type: Application
    Filed: May 30, 2023
    Publication date: September 14, 2023
    Inventors: Nikolai KLEY, Jan TAVERNIER, Leander HUYGHE, Thomas WUEEST
  • Therapeutic targeting of non-cellular structures
    Patent number: 11753463
    Abstract: The present invention relates, in part, to chimeric proteins that bind a non-cellular structure and their use as therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the chimeric proteins and their use in the treatment of various diseases.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: September 12, 2023
    Assignee: Orionis Biosciences BV
    Inventors: Nikolai Kley, Jan Tavernier, Leander Huyghe, Anje Cauwels
  • Bi-functional chimeric proteins and uses thereof
    Patent number: 11702477
    Abstract: The present invention relates, in part, to targeted chimeric proteins with beneficial therapeutic effects, including, for example, effects mediated by mutant forms of soluble agents that are part of the chimeric proteins. Pharmaceutical compositions comprising the chimeric proteins are also provided. The present invention finds use in the treatment of various disease and disorders.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: July 18, 2023
    Assignees: Orionis Biosciences BV, VIB VZW, Universiteit Gent
    Inventors: Nikolai Kley, Jan Tavernier, Leander Huyghe, Thomas Wueest
  • COMBINATION THERAPY WITH CD13-TARGETED CHIMERIC PROTEINS OR CHIMERIC PROTEIN COMPLEXES
    Publication number: 20220249609
    Abstract: The present invention relates, in part, to chimeric protein or chimeric protein complex comprising a CD13 targeting moiety and a signaling agent (e.g., without limitation TNF or IFN-?) and methods of treatment using such compositions.
    Type: Application
    Filed: June 18, 2020
    Publication date: August 11, 2022
    Inventors: Nikolai KLEY, Jan TAVERNIER, Leander HUYGHE
  • THERAPEUTIC TARGETING OF NON-CELLULAR STRUCTURES
    Publication number: 20210238264
    Abstract: The present invention relates, in part, to chimeric proteins that bind a non-cellular structure and their use as therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the chimeric proteins and their use in the treatment of various diseases.
    Type: Application
    Filed: May 12, 2017
    Publication date: August 5, 2021
    Inventors: Nikolai KLEY, Jan TAVERNIER, Leander HUYGHE, Anje CAUWELS
  • BI-FUNCTIONAL CHIMERIC PROTEINS AND USES THEREOF
    Publication number: 20190144553
    Abstract: The present invention relates, in part, to targeted chimeric proteins with beneficial therapeutic effects, including, for example, effects mediated by mutant forms of soluble agents that are part of the chimeric proteins. Pharmaceutical compositions comprising the chimeric proteins are also provided. The present invention finds use in the treatment of various disease and disorders.
    Type: Application
    Filed: November 11, 2016
    Publication date: May 16, 2019
    Inventors: Nikolai KLEY, Jan TAVERNIER, Leander HUYGHE, Thomas WUEEST
  • Method of treating cancer by combination therapy using TNF and alpha-galactosylceramide
    Patent number: 7959907
    Abstract: The invention relates to the treatment of cancer. More specifically the invention shows that the anti-cancer activity in mammals can be augmented by administering to the mammalian host a combination of a synergistically effective amount of TNF and alfa-galactosylceramide.
    Type: Grant
    Filed: February 20, 2008
    Date of Patent: June 14, 2011
    Assignees: VIB VZW, Universiteit Gent
    Inventors: Peter Brouckaert, Dirk Elewaut, Leander Huyghe
  • COMBINATION THERAPY USING TNF AND ALFA-GALACTOSYL CERAMIDE
    Publication number: 20100166697
    Abstract: The invention relates to the treatment of cancer. More specifically the invention shows that the anti-cancer activity in mammals can be augmented by administering to the mammalian host a combination of a synergistically effective amount of TNF and alfa-galactosylceramide.
    Type: Application
    Filed: February 20, 2008
    Publication date: July 1, 2010
    Inventors: Peter Brouckaert, Dirk Elewaut, Leander Huyghe