Patents by Inventor Leander Merritt

Leander Merritt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aromatic ether derivatives useful as thrombin inhibitors
    Patent number: 7700628
    Abstract: This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: April 20, 2010
    Assignee: Eli Lilly and Company
    Inventors: Ankush Baburao Argade, Theodore Goodson, Jr., David Kent Herron, Sajan Joseph, Salvatore Donato Lepore, Angela Lynn Marquart, John Joseph Masters, David Mendel, Leander Merritt, Andrew Michael Ratz, Gerald Floyd Smith, Anne Louise Tebbe, Michael Robert Wiley, Ying Kwong Yee
  • Antithrombotic ethers
    Patent number: 7615568
    Abstract: This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor (I).
    Type: Grant
    Filed: April 13, 2004
    Date of Patent: November 10, 2009
    Assignee: Eli Lilly and Company
    Inventors: Jeffry Bernard Franciskovich, David Kent Herron, Jared Harris Linebarger, Angela Lynn Marquart, John Joseph Masters, David Mendel, Leander Merritt, Andrew Michael Ratz, Gerald Floyd Smith, Leland Otto Weigel, Michael Robert Wiley, Ying Kwong Yee
  • AROMATIC ETHER DERIVATIVES USEFUL AS THROMBIN INHIBITORS
    Publication number: 20090227566
    Abstract: This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).
    Type: Application
    Filed: November 10, 2005
    Publication date: September 10, 2009
    Inventors: Ankush Baburao Argade, Theodore Goodson, JR., David Kent Herron, Sajan Joseph, Salvatore Donato Lepore, Angela Lynn Marquart, John Joseph Masters, David Mendel, Leander Merritt, Andrew Michael Ratz, Gerald Floyd Smith, Anne Lousie Tebbe, Michael Robert Wiley, Ying Kwong Yee
  • Antithrombotic aromatic ethers
    Patent number: 7511066
    Abstract: This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: March 31, 2009
    Assignee: Eli Lilly and Company
    Inventors: Jeffry Bernard Franciskovich, Theodore Goodson, Jr., David Kent Herron, Angela Lynn Marquart, John Joseph Masters, David Mendel, Leander Merritt, Andrew Michael Ratz, Gerald Floyd Smith, Michael Robert Wiley, Ying Kwong Yee
  • Antithrombotic Ethers
    Publication number: 20080108594
    Abstract: This application relates to a compound of formula I (or a pro-drug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor (I).
    Type: Application
    Filed: April 13, 2004
    Publication date: May 8, 2008
    Applicant: Eli Lilly and Company
    Inventors: Jeffry Bernard Franciskovich, David Kent Herron, Jared Harris Linebarger, Angela Lynn Marquart, John Joseph Masters, David Mendel, Leander Merritt, Andrew Michael Ratz, Gerald Floyd Smith, Leland Otto Weigel, Michael Robert Wiley, Ying Kwong Yee
  • Antithrombotic aromatic ethers
    Publication number: 20070027185
    Abstract: This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.
    Type: Application
    Filed: September 24, 2004
    Publication date: February 1, 2007
    Applicant: ELILILLY AND COMPANY
    Inventors: Jeffry Franciskovich, Theodore Goodson, David Herron, Angela Marquart, John Masters, David Mendel, Leander Merritt, Andrew Ratz, Gerald Smith, Michael Wiley, Ying Yee
  • Heterocyclic compounds and their use
    Patent number: 6194416
    Abstract: The present invention relates to therapeutically active compounds of the formula: wherein G is an azacyclic or azabicyclic ring system, W is oxygen or sulfur, r is 0, 1, or 2, and R is defined in the specification; and to methods of treatment using, and pharmaceutical compositions comprising, these compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
    Type: Grant
    Filed: April 10, 1997
    Date of Patent: February 27, 2001
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, Jon K. Reel, John S. Ward, Celia A. Whitesitt
  • Heterocyclic compounds and their use
    Patent number: 6187776
    Abstract: The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: February 13, 2001
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, John S. Ward
  • Heterocyclic compounds
    Patent number: 6187798
    Abstract: The present invention provides aza-bicyclo[2.2.1]heptane compounds which are useful for modulating a muscarinic receptor.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: February 13, 2001
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, Lone Jeppesen, John S. Ward
  • Heterocyclic compounds
    Patent number: 6117883
    Abstract: The present invention provides heterocyclic compounds which are useful for modulating a muscarinic receptor.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: September 12, 2000
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, Jon K Reel, Celia A Whitesitt, Richard L Simon
  • Heterocyclic compounds and their use
    Patent number: 6071900
    Abstract: The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: June 6, 2000
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, John S. Ward
  • Heterocyclic compounds
    Patent number: 6069159
    Abstract: The present invention provides heterocyclic compounds which are useful for modulating a muscarinic receptor.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: May 30, 2000
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, Lone Jeppesen, John S Ward
  • Process for preparing 1,2,5-thiadiazole containing ethers
    Patent number: 6040442
    Abstract: The presently claimed process provides a method for preparing compounds of the formula ##STR1## phosphorous (III) compound and a diester of azodicarboxylate.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: March 21, 2000
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, John S. Ward
  • Heterocyclic compound and their use
    Patent number: 6030966
    Abstract: The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
    Type: Grant
    Filed: July 28, 1999
    Date of Patent: February 29, 2000
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, John S. Ward
  • Heterocyclic compounds and their use
    Patent number: 5998404
    Abstract: The present invention relates to therapeutically active azacyclic or azabicyclic compounds of formula I ##STR1## and to pharmaceutical formulations comprising these compounds and methods of treatment comprising administering these compounds to a subject in need of treatment. The novel oxadiazole compounds, such as (.+-.)-3-butyloxy-4-(1-azabicyclo[2.2.2]octyl-3-oxy)-1,2,5-oxadiazole, are useful in treating central nervous system disorders caused by malfunctioning of the muscarinic cholinergic system.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: December 7, 1999
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, John S. Ward
  • Heterocyclic compounds and their preparation and use
    Patent number: 5929247
    Abstract: The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 27, 1999
    Assignee: Eli Lilly and Company
    Inventors: Charles A. Alt, Leander Merritt, Gary A. Rhodes, Roger L. Robey, Eldon E. Van Meter, John S. Ward, Charles H. Mitch
  • Heterocyclic compounds and their preparation and use
    Patent number: 5821370
    Abstract: The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 13, 1998
    Assignee: Eli Lilly and Company
    Inventors: Charles A. Alt, Leander Merritt, Gary A. Rhodes, Roger L. Robey, Eldon E. Van Meter, John S. Ward
  • Heterocyclic compounds and their preparation and use
    Patent number: 5821371
    Abstract: The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 13, 1998
    Assignee: Eli Lilly and Comany
    Inventors: Charles A. Alt, Leander Merritt, Gary A. Rhodes, Roger L. Robey, Eldon E. Van Meter, John S. Ward, Charles H. Mitch
  • Heterocyclic compounds and their preparation and use
    Patent number: 5672709
    Abstract: The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 30, 1997
    Assignee: Eli Lilly and Company
    Inventors: Charles A. Alt, Leander Merritt, Gary A. Rhodes, Roger L. Robey, Eldon E. Van Meter, John S. Ward, Charles H. Mitch
  • Heterocyclic compounds and their preparation and use
    Patent number: 5665745
    Abstract: The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 9, 1997
    Assignee: Eli Lilly and Company
    Inventors: Charles A. Alt, Leander Merritt, Gary A. Rhodes, Roger L. Robey, Eldon E. Van Meter, John S. Ward, Charles H. Mitch