Patents by Inventor Leandro Christmann

Leandro Christmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies produced in the avian oviduct
    Publication number: 20100310552
    Abstract: The invention relates to transgenic avians which produce antibodies in the egg white by introducing a nucleic acid sequence into the genome of an avian embryo wherein the nucleic acid sequence comprises a nucleotide sequence encoding an antibody and to the antibodies and to methods related thereto.
    Type: Application
    Filed: April 21, 2010
    Publication date: December 9, 2010
    Inventors: Jeffrey C. Rapp, Leandro Christmann, Markley C. Leavitt
  • In vivo transfection in avians
    Patent number: 7795496
    Abstract: The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a cell of the oviduct tissue and is expressed.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: September 14, 2010
    Assignee: Synageva BioPharma Corp.
    Inventors: Leandro Christmann, Markley C. Leavitt, Dawn M. Eberhardt, Timalynn M. Matthews
  • Production of heterologous protein in the avian oviduct
    Publication number: 20100083389
    Abstract: The invention includes methods of making transgenic avians by introducing a nucleic acid sequence into the genome of an avian embryo wherein the nucleic acid sequence comprises a nucleotide sequence encoding a heterologous protein, developing the avian embryo to hatch, developing the hatched chick to sexual maturity and obtaining offspring from the sexually mature hatched chick which produce egg white containing the heterologous protein.
    Type: Application
    Filed: May 1, 2009
    Publication date: April 1, 2010
    Inventors: Jeffrey C. Rapp, Leandro Christmann, Alex J. Harvey, Markley C. Leavitt
  • RNA interference and disease resistance in avians
    Publication number: 20090313712
    Abstract: The invention relates to transgenic avians whose genome contains nucleotide sequences which encode therapeutic polynucleotides that correspond to one or more certain sequences in the genome of an avian pathogen.
    Type: Application
    Filed: April 1, 2009
    Publication date: December 17, 2009
    Inventors: Leandro Christmann, Rapp C. Jeffrey
  • In vivo transfection in avians
    Publication number: 20090193534
    Abstract: The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a cell of the oviduct tissue and is expressed.
    Type: Application
    Filed: February 13, 2009
    Publication date: July 30, 2009
    Inventors: Leandro Christmann, Markley C. Leavitt, Dawn M. Eberhardt, Timalynn m. Matthews
  • Artificial chromosomes and transchromosomic avians
    Publication number: 20090188002
    Abstract: The invention includes avians containing an artificial chromosome in their genome and methods of making the avians.
    Type: Application
    Filed: December 12, 2008
    Publication date: July 23, 2009
    Inventors: Leandro Christmann, Dawn M. Eberhardt, Markley C. Leavitt, Alex J. Harvey
  • Production of a transgenic avian by cytoplasmic injection
    Patent number: 7550650
    Abstract: This invention provides methods for the stable introduction of heterologous coding sequences into the genome of a bird and expressing the coding sequences to produce desired proteins or to alter the phenotype of the bird. The present invention provides preferred methods for introducing a transgene into the cytoplasm of avian embryonic cells by cytoplasmic microinjection. The embryo then develops into a transgenic adult capable of expressing a heterologous protein and/or capable of generating a line of transgenic birds through breeding. Synthetic vectors and gene promoters useful in the methods are also provided by the present invention, as are transgenic birds that express heterologous protein and avian eggs containing heterologous protein.
    Type: Grant
    Filed: October 2, 2003
    Date of Patent: June 23, 2009
    Assignee: Synageva BioPharma Corp.
    Inventors: Jeffrey C. Rapp, Leandro Christmann
  • Methods of protein production in cell lines
    Patent number: 7432103
    Abstract: The present invention relates to cells that can be passaged in culture and can be used for, among other things, promoter assays and the production of heterologous proteins.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: October 7, 2008
    Assignee: AviGentics, Inc.
    Inventors: Jeffrey C. Rapp, Stephen H. Parker, Markley C. Leavitt, Dawn M. Eberhardt, Leandro Christmann, Alex J. Harvey
  • RNA interference and disease resistance in avians
    Publication number: 20080222743
    Abstract: The invention relates to transgenic avians whose genome contains nucleotide sequences which encode therapeutic polynucleotides that correspond to one or more certain sequences in the genome of an avian pathogen.
    Type: Application
    Filed: May 1, 2007
    Publication date: September 11, 2008
    Inventors: Leandro Christmann, Jeffrey C. Rapp
  • In vivo transfection in avians
    Publication number: 20080222744
    Abstract: The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a cell of the oviduct tissue and is expressed.
    Type: Application
    Filed: April 18, 2008
    Publication date: September 11, 2008
    Inventors: Leandro Christmann, Jeffrey C. Rapp
  • Methods of protein production in cell lines
    Publication number: 20080145861
    Abstract: The present invention relates to cells that can be passaged in culture and can be used for, among other things, promoter assays and the production of heterologous proteins.
    Type: Application
    Filed: February 1, 2008
    Publication date: June 19, 2008
    Inventors: Jeffrey C. Rapp, Stephen H. Parker, Markley C. Leavitt, Dawn M. Eberhardt, Leandro Christmann, Alex J. Harvey
  • In vivo transfection in avians
    Patent number: 7381712
    Abstract: The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a cell of the oviduct tissue and is expressed.
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: June 3, 2008
    Assignee: AviGenics, Inc.
    Inventors: Leandro Christmann, Markley C. Leavitt, Dawn M. Eberhardt, Timalynn M. Matthews
  • Microinjection devices and methods of use
    Publication number: 20080124787
    Abstract: The present invention provides for microinjection devices comprising a needle and a viewing instrument wherein the viewing instrument provides viewing of an object to an operator from an angle other than a right angle to the object.
    Type: Application
    Filed: January 4, 2008
    Publication date: May 29, 2008
    Inventor: Leandro Christmann
  • Cell lines
    Patent number: 7351582
    Abstract: The present invention relates to cells that can be passaged in culture and can be used for, among other things, promoter assays and the production of heterologous proteins.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: April 1, 2008
    Assignee: AviGenics, Inc.
    Inventors: Jeffrey C. Rapp, Stephen H. Parker, Markley C. Leavitt, Dawn M. Eberhardt, Leandro Christmann, Alex J. Harvey
  • Microinjection devices and methods of use
    Patent number: 7339090
    Abstract: The present invention provides for microinjection devices comprising a needle and a viewing instrument wherein the viewing instrument provides magnified viewing of an object to an operator from an angle other than a right angle to the object.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: March 4, 2008
    Assignee: AviGenics, Inc.
    Inventor: Leandro Christmann
  • Production of a transgenic avian by cytoplasmic injection
    Patent number: 7312374
    Abstract: This invention provides methods for the stable introduction of heterologous coding sequences into the genome of a bird and expressing the coding sequences to produce desired proteins or to alter the phenotype of the bird. The present invention provides preferred methods for introducing a transgene into the cytoplasm of avian embryonic cells by cytoplasmic microinjection. The embryo then develops into a transgenic adult capable of expressing a heterologous protein and/or capable of generating a line of transgenic birds through breeding. Synthetic vectors and gene promoters useful in the methods are also provided by the present invention, as are transgenic birds that express heterologous protein and avian eggs containing heterologous protein.
    Type: Grant
    Filed: September 18, 2002
    Date of Patent: December 25, 2007
    Assignee: AviGenics, Inc
    Inventors: Jeffrey C. Rapp, Leandro Christmann
  • Production of a transgenic avian by cytoplasmic injection
    Publication number: 20070180546
    Abstract: This invention provides methods for the stable introduction of heterologous coding sequences into the genome of a bird and expressing the coding sequences to produce desired proteins or to alter the phenotype of the bird. The present invention provides preferred methods for introducing a transgene into the cytoplasm of avian embryonic cells by cytoplasmic microinjection. The embryo then develops into a transgenic adult capable of expressing a heterologous protein and/or capable of generating a line of transgenic birds through breeding. Synthetic vectors and gene promoters useful in the methods are also provided by the present invention, as are transgenic birds that express heterologous protein and avian eggs containing heterologous protein.
    Type: Application
    Filed: October 2, 2003
    Publication date: August 2, 2007
    Inventors: Jeffrey Rapp, Leandro Christmann
  • Cell lines
    Publication number: 20060286638
    Abstract: The present invention relates to cells that can be passaged in culture and can be used for, among other things, promoter assays and the production of heterologous proteins.
    Type: Application
    Filed: June 16, 2006
    Publication date: December 21, 2006
    Inventors: Jeffrey Rapp, Stephen Parker, Markley Leavitt, Dawn Eberhardt, Leandro Christmann, Alex Harvey
  • Artificial chromosomes and transchromosomic avians
    Publication number: 20060174364
    Abstract: The invention includes avians containing an artificial chromosome in their genome and methods of making the avians.
    Type: Application
    Filed: February 24, 2006
    Publication date: August 3, 2006
    Inventors: Leandro Christmann, Dawn Eberhardt, Markley Leavitt, Alex Harvey
  • Visualization of avian eggs
    Publication number: 20060166260
    Abstract: The invention includes methods of visualizing and manipulating avian eggs employing TPLSM.
    Type: Application
    Filed: March 29, 2006
    Publication date: July 27, 2006
    Inventor: Leandro Christmann