Abstract: This invention relates to methods to diagnose colon cancer and other proliferative diseases. Gene 26#77 is identified herein as a novel oncogene. Methods are provided for diagnosing and treating a disease or disorder characterized by amplification of the 26#77 gene and/or overexpression of 26#77 gene products. The 26#77 gene is located on chromosome 20q13.2, a region whose amplification is associated with a poor cancer prognosis. The 26#77 gene is amplified and 26#77 RNA and protein are overexpressed in 60% of colorectal cancers.

Abstract: This invention relates to methods to diagnose colon cancer and other proliferative diseases. Gene 26#77 is identified herein as a novel oncogene. Methods are provided for diagnosing and treating a disease or disorder characterized by amplification of the 26#77 gene and/or overexpression of 26#77 gene products. The 26#77 gene is located on chromosome 20q13.2, a region whose amplification is associated with a poor cancer prognosis. The 26#77 gene is amplified and 26#77 RNA and protein are overexpressed in 60% of colorectal cancers.

Abstract: A flexible handle extension for a pivoted handle of a light-duty door latch assembly of a screen door and the like and a method of substantially reducing an opening force required to unlatch the assembly from the door jam. The handle extension includes an elongated semi-flexible tube sized in inner diameter to biasingly slidably engage over and be self-retaining on the handle and sized in length to be at least twice the length of the handle. The combination of handle extension length and semi-flexibility substantially reduces door opening force while diminishing the seriousness of body injury when the handle and attached handle extension are accidentally bumped or struck by an individual.