Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of Ataxia-telangiectasia and RAD-3-related protein kinase (ATR). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and methods of their preparation and use.

Abstract: The application provides a computer-implemented method for simulating a reflected audio path in a virtual environment, the virtual environment comprising a source, a receiver, an obstacle, and a sound-reflective boundary, the reflected audio path associated with reflection at the sound-reflective boundary, and the method comprising: simulating, by an image-source method, the reflected audio path between the source and the receiver, the image-source method comprising: generating, by mirroring the source in the sound-reflective boundary, a mirror image source, and determining a simulated reflected audio path along a line segment between the receiver and the mirror image source; generating, by mirroring the obstacle in the sound-reflective boundary, a mirror image obstacle; performing a line-of-sight check between the receiver and the mirror image source; and, when at least one of the obstacle and the mirror image obstacle lies along the line segment between the mirror image source and the receiver, performing a

Abstract: Microbiota restoration therapy compositions and methods for manufacturing, processing, and/or delivering microbiota restoration therapy compositions are disclosed. An example method for manufacturing a microbiota restoration therapy composition may include collecting a human fecal sample and adding a diluent to the human fecal sample to form a diluted sample. The diluent may include a cryoprotectant. The method may also include mixing the diluted sample with a mixing apparatus and filtering the diluted sample. Filtering may form a filtrate. The method may also include transferring the filtrate to a sample bag and sealing the sample bag.

Abstract: This present disclosure seals the light propagation path in an optical interconnection element from external contaminants. The optical interconnection element includes a reflective surface, which can also be sealed from external contaminants Additional novel concepts include all enclosed sealed regions of the optical interconnection element being fluidly connected and making the final seal of the optical interconnection element with a thin plate, which can bend reducing the pressure differential between the ambient environment and the sealed internal volume of the optical interconnection element.

Abstract: Systems and methods for moving data between a storage device and a processing element are disclosed. The storage device may include: a non-volatile storage medium; a first interface for communicating with a computing device; and a second interface for communicating with a processing element over a data communications network. The processing element may include a processing circuit that is configured to: receive a first request from the computing device via the first interface, where the first request identifies a first memory address associated with the first memory; retrieve first data from the non-volatile storage medium based on the first request; and transmit the first data to the processing element via the second interface for storing the first data in the first memory based on the first memory address.

Abstract: One or more embodiments of the present disclosure are directed to systems and methods for host and device cooperation. In some embodiments, a storage device comprises a first memory for storing data; a second memory configured with a cache coherent protocol; and a processing circuit coupled to the first memory and the second memory. The processing circuit is configured to: store, in the second memory, information for managing the storage device, wherein the information is shared with a computing device via the cache coherent protocol; receive a first value from the computing device, the first value associated with a first block of the first memory; and take an action with respect to the first block based on the first value, wherein the action is for managing the first memory.

Abstract: Described is a system and method for routing output information to one or more of a plurality of output devices. In one implementation, output information that includes information to be presented and a location information identifying where the output information is to be presented may be generated by an output host. The output information is received by an output router that determines, based on the location information, an output device and routes the output information to the output device for presentation.

Abstract: A stator for an electric machine comprises a cylindrical core defining an inner cylindrical surface and an outer cylindrical surface with a plurality of slots formed between the inner cylindrical surface and the outer cylindrical surface. Windings are positioned on the cylindrical core. The leads of the windings include a plurality of inner leads associated with conductors in an inner layer of the slots and a plurality of outer leads associated with conductors in an outer layer of the slots. A bus bar assembly includes a plurality of inner bus bars and a plurality of outer bus bars, the plurality of inner bus bars connected to the plurality of inner leads, and the plurality of outer bus bars connected to the plurality of outer leads. The plurality of outer bus bars are positioned radially outward from the end turns of the windings and radially inward from the outer cylindrical surface.

Abstract: A data processing apparatus includes receiving circuitry to receive graphics data for at least a portion of a virtual environment, the graphics data including a plurality of virtual objects, a machine learning model trained to output data indicative of an object classification for one or more of the virtual objects in dependence upon the graphics data, assignment circuitry to assign one or more of the virtual objects to one or more virtual object groups in dependence upon the object classification for one or more of the virtual objects, where the virtual objects assigned to a same virtual object group have a same object classification, and control circuitry to share first interaction data associated with a first virtual object assigned to a virtual object group with a second virtual object assigned to the virtual object group to thereby permit use of the first interaction data for the second virtual object in response to a user interaction with the second virtual object in the virtual environment.

Abstract: The present invention relates to a flow-through device comprising at least one separation column wherein a first packing component, which comprises particles of alumina and/or silica, and a second packing component, which comprises a powder of one or more hygroscopic salts are provided. The two packing components may be blended or layered in the device, which may comprise a single tube or a plurality of tubes arranged in a plate format, such as the wells of a multiwall plate or tubes in a rack. In addition, the invention relates to a method for removing one or more matrix components, such as pigments, from a biological sample, by passing said sample across a first packing component, which comprises particles of alumina and/or silica, and a second packing component, which comprises a powder of one or more hygroscopic salts.

Abstract: Hybrid buildings, hybrid building systems and methods of constructing hybrid buildings are disclosed. First and second building sections forming part of such buildings are also disclosed. One such hybrid residential building (1600) comprises a first building section (1610) and a second building section (1620). The first building section is an on-site construction at a final location for the building and comprises a lower storey (1611) defining an internal volume (1613) that provides a lower living space (1615) within the building, and an upper storey (1617) defining an internal volume (1619) that provides an upper living space (1621) within the building. The second building section defines an internal volume (1623) and is transportable to the final location in a substantially assembled form. The first and second building sections are connected at the final location to form the building.

Abstract: Hybrid buildings, hybrid building systems and methods of constructing hybrid buildings are disclosed. First and second building sections forming part of such buildings are also disclosed. One such hybrid residential building comprises a first building section and a second building section. The first building section is an on-site construction at a final location for the building and comprises an internal volume that provides a living space within the building. The second building section defines an internal volume and is transportable to the final location in a substantially assembled form. The first and second building sections are connected at the final location to form the building.

Abstract: Hybrid buildings, hybrid building systems, methods of constructing hybrid buildings, and a method of ventilating such a building are disclosed. First and second building sections forming part of such buildings are also disclosed. One such hybrid residential building (1800) comprises a first building section (1810) and a second building section (1820). The first building section is an on-site construction at a final location for the building and defines an internal volume (1813) that provides a living space (1815) within the building. The second building section defines an internal volume (1823) and is transportable to the final location in a substantially assembled form. The first and second building sections are connected at the final location to form the building.

Abstract: Hybrid buildings, hybrid building systems and methods of constructing hybrid buildings are disclosed. First and second building sections forming part of such buildings are also disclosed. One such hybrid residential building (1600) comprises a first building section (1610) and a second building section (1620). The first building section is an on-site construction at a final location for the building and comprises a lower storey (1611) defining an internal volume (1613) that provides a lower living space (1615) within the building, and an upper storey (1617) defining an internal volume (1619) that provides an upper living space (1621) within the building. The second building section defines an internal volume (1623) and is transportable to the final location in a substantially assembled form. The first and second building sections are connected at the final location to form the building.

Abstract: A computer-implemented method for decorrelating a set of simulated audio signals in a virtual environment is disclosed. The method comprises the steps of: obtaining a first set of decorrelation filters; evaluating the first set of decorrelation filters to determine a similarity metric representing the similarity between the first set of decorrelation filters; if the similarity metric is above a predetermined threshold, regenerating the set of decorrelation filters so as to reduce the similarity metric; and applying the regenerated set of decorrelation filters to the simulated audio signals.

Abstract: In one aspect, an example methodology implementing the disclosed techniques includes receiving information regarding a customer to onboard to a managed service and determining one or more relevant features from the information regarding the customer, the one or more relevant features correlated with historical onboarding times. The method also includes determining, using a machine learning (ML) model, an expected time to onboard the customer to the managed service based on the one or more relevant features.

Abstract: A bracket for suspending multiple line segments at an elevated location is disclosed. The bracket has a back portion to engage against a supporting surface at the elevated location. The back portion has a left segment and a right segment. The bracket has at least one of a left arm extending from the left segment or a right arm extending from the right segment. The bracket has at least one of a first left seat extending from the left arm, a second left seat extending from the left arm, a first right seat extending from the right arm, or a second right seat extending from the right arm. At least one of the multiple line segments are supported by at least one of the first left seat, the second left seat, the first right seat, or the second right seat.

Abstract: A system comprising a feedback device comprising one or more elements operable to generate an output in response to an input from a processing device, a microphone operable to capture one or more audio inputs, an input detection unit operable to detect one or more inputs to the feedback device from the processing device, and a response generation unit operable to generate a response to the detected input in dependence upon the input and at least a distance between an element associated with the corresponding output and the microphone.

Abstract: A mould tool is disclosed, for use in repairing the eroded leading edge of a wind turbine blade. The mould tool comprises a flexible sheet and a framework which is flexible in one direction, for conforming to the curved edge of the blade, but rigid in the other direction. The mould tool may include tapered side walls. Preferably, a method or repair involves use of a mould tool with tapered side walls, and use of a similar mould tool which lacks the tapered side walls. To repair a section of the edge of a turbine blade, first stripes of resin are injected, spaced apart along the length of the section, using the mould with side walls. The gaps between the stripes are then filled using the mould without side walls.

Abstract: Hybrid buildings, hybrid building systems and methods of constructing hybrid buildings are disclosed. First and second building sections forming part of such buildings are also disclosed. One such hybrid residential building (1600) comprises a first building section (1610) and a second building section (1620). The first building section is an on-site construction at a final location for the building and comprises a lower storey (1611) defining an internal volume (1613) that provides a lower living space (1615) within the building, and an upper storey (1617) defining an internal volume (1619) that provides an upper living space (1621) within the building. The second building section defines an internal volume (1623) and is transportable to the final location in a substantially assembled form. The first and second building sections are connected at the final location to form the building.