Patents by Inventor Lee A. Phebus

Lee A. Phebus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-HT.sub.1F agonists intermediates
    Patent number: 5998622
    Abstract: This invention provides 5-HT.sub.1F agonists of Formula I; ##STR1## where A-B, X, and R are as defined in the specification. The invention also encompasses pharmaceutical formulations employing compounds of Formula I as well as methods of treating conditions associated with 5-HT.sub.1F activation employing these compounds or compositions. The invention also provides intermediates useful for the preparation of the compounds of Formula I.
    Type: Grant
    Filed: July 9, 1998
    Date of Patent: December 7, 1999
    Assignee: Eli Lilly and Company
    Inventors: Sandra Ann Filla, Kirk W. Johnson, Lee A. Phebus, John Mehnert Schaus
  • Nitropyridine compound
    Patent number: 5919936
    Abstract: This invention provides 5-HT.sub.1F agonists of Formula I: ##STR1## where A-B, X, and R are as defined in the specification. The invention also encompasses pharmaceutical formulations employing compounds of Formula I as well as methods of treating conditions associated with 5-HT.sub.1F activation employing these compounds or compositions. The invention also provides intermediates useful for the preparation of the compounds of Formula I.
    Type: Grant
    Filed: July 9, 1998
    Date of Patent: July 6, 1999
    Assignee: Eli Lilly and Company
    Inventors: Sandra Ann Filla, Kirk W. Johnson, Lee A. Phebus, John Mehnert Schaus
  • 5-HT.sub.1F agonists
    Patent number: 5817671
    Abstract: This invention provides 5-HT.sub.1F agonists of Formula I: ##STR1## where A--B, X, and R are as defined in the specification. The invention also encompasses pharmaceutical formulations employing compounds of Formula I as well as methods of treating conditions associated with 5-HT.sub.1F activation employing these compounds or compositions. The invention also provides intermediates useful for the preparation of the compounds of Formula I.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: October 6, 1998
    Assignee: Eli Lilly and Company
    Inventors: Sandra Ann Filla, Kirk W. Johnson, Lee A. Phebus, John Mehnert Schaus
  • Serotonin agonist in combination with a tachykinin receptor antagonist in the treatment or prevention of migraine
    Patent number: 5744482
    Abstract: Methods for the treatment or prevention of migraines comprising administering to a mammal in need thereof a combination of a tachykinin receptor antagonist and a serotonin agonist are disclosed. The administration may be concurrent or sequential, with either of the two activities being administered first.
    Type: Grant
    Filed: October 5, 1994
    Date of Patent: April 28, 1998
    Assignee: Eli Lilly and Company
    Inventors: Marlene L. Cohen, Kirk W. Johnson, Lee A. Phebus
  • 5-HT.sub.1F mediated inhibition of neurogenic meningeal extravasation: a method for the treatment of migraine
    Patent number: 5698571
    Abstract: The present invention provides a method for the treatment of migraine with compounds or compositions that are selective agonists of 5-HT.sub.1F receptors relative to other serotonin receptors that produce unwanted effects like vasoconstriction. The neurogenic meningeal extravasation that leads to the pain of migraine is inhibited.
    Type: Grant
    Filed: October 5, 1994
    Date of Patent: December 16, 1997
    Assignee: Eli Lilly and Company
    Inventors: James E. Audia, Marlene L. Cohen, Kirk W. Johnson, Lee A. Phebus, Theresa Branchek