Abstract: The present disclosure relates to compositions and methods for reducing expression of MYC gene in a cell. In some embodiments, an expression repressor comprises a targeting moiety that binds a MYC promoter, anchor sequence, or super-enhancer. In some embodiments, the expression repressor comprises an effector moiety that represses transcription or methylates DNA. Systems comprising two expression repressors are also disclosed. The compositions can be used, for example, to treat cancers such as HCC or NSCLC.

Abstract: A method of X-ray digital image correlation is provided. The method comprises aligning cameras of an X-ray imaging system, wherein the X-ray imaging system comprises two X-ray sources pointed at a target area at a stereo angle and two corresponding X-ray detectors behind the target area. The X-ray imaging system is tuned to determine power levels of the X-ray sources that maximize image contrast and signal-to-noise ratio. The system is calibrated to determine intrinsic and extrinsic stereoscopic imaging parameters. A specimen with a random contrast pattern comprising an X-ray attenuating material is placed in the target area. Stereoscopic X-ray images are taken of the specimen and processed according to the power levels of the X-ray sources to maximize image contrast and signal-to-noise ratio and remove background objects. Kinematic quantities are determined according to changes in the contrast pattern over a number of successive images.

Abstract: Processes for protecting steel chains from corrosion and steel chains thus protected are provided. The process includes using finite element analysis to determine stress levels within links of a steel chain having a plurality of connected links. Regions of each link of the chain corresponding to high stress levels are identified. Target areas corresponding to the regions identified are indicated for coating each link of the chain with a sacrificial coating. Thermally sprayed alumina can be used as the sacrificial coating.

Abstract: Processes for protecting steel chains from corrosion and steel chains thus protected are provided. The process includes using finite element analysis to determine stress levels within links of a steel chain having a plurality of connected links. Regions of each link of the chain corresponding to high stress levels are identified. Target areas corresponding to the regions identified are indicated for coating each link of the chain with a sacrificial coating. Thermally sprayed alumina can be used as the sacrificial coating.

Abstract: An advertising display representative of an enlarged beverage or other product container, including a body portion of a part of a container, formed as an arcuate segment, including along its side edges integrally inturned flanges, for connecting thereto of one or more hanger brackets, which are bent into particular configurations to accommodate either the mounting of the display directly to the flat surface of a wall, or for snug attachment at the corner between a pair of walls, due to the hanger bracket being configured at an approximate 90.degree. angle at inwardly angulated bent sections located proximate the back surface of the body portion for the container display of this type.

Abstract: Active laser mirror systems and methods for achieving near diffraction limited transmission of laser radiation by actively controlling a reflective surface are disclosed. The apparatus involved in the active mirror system includes a mirror having a deformable surface, a plurality of actuators attached at preselected locations to the nonreflecting side of the mirror, a control assembly for performing logic and providing drive signals to the actuators and a sensor system. The method of achieving the improved transmission includes setting the contour of a deformable reflective surface in accordance with predetermined data, reflecting the transmitted beam off the surface enroute to the target, optically monitoring the surface to determine operational changes thereon, computing corrective data, and applying appropriate changes to the mirror surface.