Abstract: A process that results in a flexible dissolvable porous solid article that can be used as a personal care composition or a fabric care composition.

Abstract: The present invention relates to personal care compositions, especially those personal care compositions in the form of an article that is a porous, dissolvable solid structure. The article has a hydrophobic surface-resident coating that can provide enhanced deposition efficiency of hydrophobic actives contained therein.

Abstract: The present invention relates to a dissolvable article in the form of a porous dissolvable solid structure, comprising from about 10% to about 50% water soluble polymer; from about 1% to about 25% plasticizer; from about 23% to about 75% surfactant; wherein said surfactants comprise one or more surfactants from Group I, wherein Group I includes anionic surfactants, and one or more surfactants from Group II, wherein Group II includes a surfactant selected from the group consisting of amphoteric, zwitterionic and combinations thereof; wherein the ratio of Group I to Group II surfactants is from about 5:95 to about 30:70; and wherein said dissolvable article has a density of from about 0.05 g/cm3 to about 0.40 g/cm3.

Abstract: New cleaning compositions including novel suds boosting and stabilization biopolymers containing alkoxy, anionic and nitrogen containing substitution are disclosed. In particular, cleaning compositions including suds boosting and stabilization biopolymers containing modified polysaccharides having alkoxy, anionic and nitrogen containing substitution and methods of forming the same are disclosed.

Abstract: The present invention relates to hair coloring and hair bleaching compositions comprising at least one oxidizing agent and a specified cross linked amphoteric polymeric thickener and preferably a source of carbonate ion. The compositions surprisingly provide improved hair colorant and bleaching compositions which deliver improved lift, lightening and color delivery whilst minimizing damage which are easy to manufacture and have long shelf life stability.

Abstract: Personal care compositions, especially those personal care compositions in the form of an article that is a porous, dissolvable solid structure.

Abstract: An electrical power metering system. The electrical power metering system may include a plurality of gated power receptacles, each of the gated power receptacles being configured to selectively provide electrical power in response to receiving a wireless signal. The system may further include a service application configured to receive a request to provide electrical power for one of the plurality of gated power receptacles, the request including an identifier that designates the one of the plurality of gated power receptacles at which electrical power is requested. The system may further include a local host application executable on a computing device, the local host application being configured to send the wireless signal via a coordinator module to the one of the plurality of gated power receptacles to provide electrical power in response to receiving a communication from the service application that includes the identifier.

Abstract: The invention relates to SMYD3 methyltransferase (SMYD3), SMYD3 binding pockets or SMYD3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to SMYD3 methyltransferase protein, complexes of SMYD3 methyltransferase protein, homologues thereof, or SMYD3-like protein or protein complexes.

Abstract: Cross-linked ampholytic polymers that may be used as rheological modifiers, and/or absorbent gelling materials are disclosed. The polymers may be storage stable in aqueous compositions comprising soluble salt, and/or an oxidizer, such as hydrogen peroxide.

Abstract: The present invention relates to hair colouring and hair bleaching compositions comprising at least one oxidizing agent and a specified cross linked amphoteric polymeric thickener and preferably a source of carbonate ion. The compositions surprisingly provide improved hair colourant and bleaching compositions which deliver improved lift, lightening and colour delivery whilst minimizing damage which are easy to manufacture and have long shelf life stability.

Abstract: The present invention provides a method for treating tumors or tumor metastases in a patient, comprising administering to the patient simultaneously or sequentially a therapeutically effective amount of an anti-cancer agent and an IGF1R inhibitor compound of Formula I combination, with or without additional agents or treatments, such as other anti-cancer drugs or radiation therapy. The IGF1R inhibitor is represented by Formula I: wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein.

Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.

Abstract: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X5, X7, R1, and Q1 are defined herein, inhibit kinase enzymes and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer. The compounds are also useful in the treatment of inflammation, allergy, asthma, disease and conditions of the immune system, disease and conditions of the nervous system, cardiovascular diseases, disease and conditions of the eye, dermatological diseases, osteoporosis, diabetes, multiple sclerosis, and infections.

Abstract: Generally, the present invention provides a system and method for processing instructions of a computer program and for indicating instruction attribute and/or status information so that the efficiency of the processing system may be increased. In architecture, the system of the present invention utilizes a pipeline, a scoreboard, and hazard detection circuitry. The pipeline processes and executes instructions of a computer program. Many of the instructions include register identifiers that identify registers where data should be written when the instructions are executed. When the data produced by execution of one of the instructions has yet to be written to the register identified by the one instruction's register identifier and is unavailable for use in executing other instructions of the program, the one instruction's register identifier is transmitted to the scoreboard.

Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.

Abstract: A processing system provides predicate data that indicates whether instructions processed by a processor pipeline should be executed by the pipeline. In architecture, the system of the present invention utilizes a register, a pipeline, and predicate circuitry. The pipeline includes a first stage and a second stage for processing instructions of a computer program. The predicate circuitry is configured to read a first predicate value from the register and to receive a second predicate value. The predicate circuitry may transmit the first predicate value read from the register to the first stage and then select between the first predicate value and the second predicate value. The predicate value selected by the predicate circuitry is transmitted to the second stage.

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract: Generally, the present invention provides a processing system and method for indicating when there is a pending write to a general register of the processing system. The processing system of the present invention utilizes a plurality of general registers, a plurality of connections, a pipeline, a scoreboard, and hazard detection circuitry. The plurality of connections corresponds respectively with the general registers. The scoreboard maintains a plurality of bits such that each bit indicates whether there is a pending write to a corresponding general register. The scoreboard transmits to the hazard detection circuitry one of the bits that is indicative of whether a pending write to the one general register exists based on a value of the one bit and based on which of the connections is used to transmit the one bit. The hazard detection circuitry then detects whether a data hazard exists based on the one bit.

Abstract: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.

Abstract: Parity and mask bit(s) are stored in a random access memory (RAM) that is coupled to a CAM. This CAM may be part of a TLB. The parity and mask bits(s) are stored in conjunction with the CAM entry write. Upon a CAM query match, the reference parity bit(s) and mask bit(s) stored at the address output by the CAM are output from the RAM. These reference parity bit(s) are compared to parity bit(s) generated from a query data value that is masked by the retrieved mask bit(s). In the absence of a CAM or RAM bit error, the reference parity bit(s) from the RAM and the parity bit(s) generated from the masked query data will match. If a CAM or RAM bit error occurred, these two sets of parity bit(s) will not match and thus an error will be detected. This error may be used as an indication that a false CAM match has occurred.