Abstract: The present invention relates to carbamoyl N-protected aminoindane derivatives, preferably carbamoyl N-Boc aminoindane derivatices, which are useful intermediates for the preparation of compounds used in the treatment of various CNS disorders, and their preparation.

Abstract: The present invention relates to the asymmetric hydrogenation of acyl enamides for preparing carbamoyl acylamide indan derivatives, which are useful intermediates for the preparation of compounds used in the treatment of various CNS disorders.

Abstract: A process for manufacturing (R)-propynylaminoindans, and alternatively, a process for manufacturing (S)-propynylaminoindans. The chiral propynylaminoindans include alkoxy or alkylcarbamates derivatives. The process comprises transfer or pressure hydrogenation in the presence of an optically active catalyst to reduce 1-indanones. The chiral product, either (S)- or (R)-indanols undergo nucleophilic substitution to produce the named product. In an additional aspect, the invention relates to novel intermediates and compounds, namely, substituted indanones, substituted (S)-indanols and substituted (R)-indanols.