Abstract: dsRNAi oligonucleotides can be used in methods for the treatment of NASH, preferably the advanced fibrotic and/or cirrhotic stages thereof, using dosage regimens comprising a loading phase followed by a maintenance phase.

Abstract: A delivery system may include a pallet wrapper system having a turntable, a camera directed toward an area above the turntable, and a stretch wrap dispenser adjacent the turntable. A computer receives images from the camera of multiple sides of a pallet loaded with packages on the turntable. The computer stitches images from different sides of the stack of packages that correspond to the same package. At least one machine learning model may be used to infer SKUs of each package. Optical character recognition may be performed in parallel on the images. The determination of the SKU of each package may be based upon the inferred SKUs and on the OCR.

Abstract: This disclosure relates to JAK1 pathway inhibitors and their use in treating vitiligo.

Abstract: Methods and apparatus for calibration of a second-order input intercept point (IIP2) of a mixer, such as a mixer in a wireless receive chain. One example circuit for mixer IIP2 calibration generally includes a first receive chain comprising a first mixer and a single tone generator having an output coupled to an input of the first mixer and configured to generate a calibration signal having a single baseband tone. One example method of mixer IIP2 calibration generally includes generating a calibration signal comprising a single baseband tone, applying the calibration signal to an input of a mixer, such that the mixer generates a differential tone at an output of the mixer, and adjusting the mixer to minimize a power of the differential tone at the output of the mixer.

Abstract: Metering dispensers include a body configured to hold a flowable composition in a chamber, a drive screw coupled to the body, and a plunger threadingly coupled to the drive screw. The plunger includes at least two annular lips that form a fluid seal with the chamber as the plunger travels along the drive screw through the chamber. A base is rotationally coupled to the body with a cam that contacts at least one tab extending externally from the body so that the tab enters at least one low point on the cam by traveling over a trailing edge of the low point, and the trailing edge then prevents the tab from exiting the low point in the direction of the trailing edge.

Abstract: A brake rotor having a composite structure may include an annular body defining opposite friction surfaces of the brake rotor. The annular body may include a core made of an Al—Si alloy, a thermal barrier layer made of a thermally insulating material disposed on the core, and a wear-resistant layer made of an Fe—Al—Si—Zr alloy disposed on the core over the thermal barrier layer. The wear-resistant layer may define a first one of the opposite friction surfaces of the annular body.

Abstract: Method and high voltage platform for vehicular all-electric on-board charging and depleting of the battery system conducted safely that consists of a single, parallel, or multiple power generation set (Power Gen-Set) apparatuses where one or more of them is a converter of mechanical energy to ac or dc electricity as a primary power supply to the phase on-board charger integrated in the propulsion system. Power Gen-Sets with other electronic components create a powertrain platform that are power suppliers for replenishing dissipated power used for propulsion. The Power Gen-Sets are in communication via AI computing module and powered by a portable energy storage device that is arranged external of the vehicle that can be removed for replenishment and/or replacement.

Abstract: A dry shampoo product that can contain a carrier comprising a volatile silicone having a viscosity of 1 cst or less, an oil absorbing starch dispersed in the volatile silicone carrier, and a propellant. The dry shampoo product can have 55% or less of volatile organic compounds, by weight of the dry shampoo product, while also delivering acceptable product performance.

Abstract: This invention pertains to improved polyester polyol compositions comprising 1,3-cyclohexanedimethanol (1,3-CHDM). Coating compositions based on such polyester polyols are capable of providing a good balance of the desirable coating properties, such as solvent resistance, acid resistance, retort resistance, microcracking resistance, and bending ability, for metal packaging applications.

Abstract: This invention pertains to improved polyester polyol compositions containing 2,2,4,4-tetramethyl-1,3-cyclobutanediol (TMCD). Coating compositions based on such TMCD polyester polyols are capable of providing a good balance of desirable coating properties such as solvent resistance, acid resistance, retort resistance, microcracking resistance, and bending ability. The TMCD coating compositions have particular utility for use in metal packaging applications.

Abstract: A measurement and testing system is disclosed herein. The measurement and testing system includes at least one data processing device operatively coupled to at least one actuator, a visual display device, and a user input device. The at least one data processing device being configured to execute computer executable stored instructions for: (i) generating a graphical user interface with a protocol section comprising one or more protocols with one or more actuator parameters for controlling the at least one actuator for a time period; (ii) receiving an input signal from the user input device that initiates an execution of one of the one or more protocols for controlling the at least one actuator; and (iii) upon receiving the input signal from the user input device, controlling the at least one actuator for the time period in accordance with the executed one of the one or more protocols.

Abstract: A computing system for pixel-based automated testing of a navigable simulated environment includes one or more processors configured to execute, in a run-time inference phase, an application testing program. The application testing program includes a machine learning model trained to detect errors in the application under test. A screen image of the simulated environment is processed by an object detection module to determine if a key object is present in the screen image. If a key object is present in the screen image, the application testing program executes an object investigation module to generate investigation inputs to investigate the key object. If a key object is not present in the screen image, the application testing program executes an environment exploration module to generate an environment exploration action to be provided to the application under test as simulated user input.

Abstract: This invention pertains to coating compositions based on polyesters containing 2,2,4,4-tetrametbyM,3-cyclobutanediol (TMCD) and modifying polyester polyols. Coatings based on such polyester blends are capable of providing a good balance of the desirable coating properties, such as solvent resistance, acid resistance, retort resistance, crazing resistance, and bending ability, for metal packaging applications.

Abstract: An animal tethering, assistive cane, and personal defense combination device incorporating user mobility and self-defense features includes a housing that defines an interior space. A leash is coupled to the housing and is positioned in the interior space. The leash is retractable type so that a cord of the leash is selectively extensible from the housing through an aperture. A user is positioned to couple the cord to a domestic animal to leash the domestic animal. A pole that is coupled to and extends from the housing comprises a plurality of nested sections so that the pole is selectively extensible and configured to serve as a mobility aid. A stun gun that is coupled to the pole distal from the housing is configured to administer an electrical shock to an attacker to incapacitate the attacker.

Abstract: The present disclosure provides herbicide composition for control of annual and perennial grasses and broadleaf weeds. In one example, a non-selective herbicide composition comprises: a post-emergent herbicidal active agent; and a burndown agent. In another example, a non-selective herbicide composition comprises: a post-emergent herbicidal active agent; a residual control active agent, and a burndown agent.

Abstract: A method for forming a thermoplastic body having regions with varied material composition and/or porosity. Powder blends comprising a thermoplastic polymer, a sacrificial porogen and an inorganic reinforcement or filler are molded to form complementary parts with closely toleranced mating surfaces. The parts are formed discretely, assembled and compression molded to provide a unitary article that is free from discernible boundaries between the assembled parts. Each part in the assembly has differences in composition and/or porosity, and the assembly has accurate physical features throughout the sections of the formed article, without distortion and nonuniformities caused by variable compaction and densification rates in methods that involve compression molding powder blends in a single step.

Abstract: Aspects of the disclosure relate to a radio frequency phase shifter. An example includes an amplification stage to produce an amplified voltage, the amplification stage having a first amplifier with a first input coupled to a first output of a hybrid coupler and a second amplifier with a complementary second input coupled to a complementary second output of the hybrid coupler. A vector modulation stage coupled to the amplification stage receives the amplified voltage and produces a modulated vector, the vector modulation stage has an in-phase section and a quadrature section to control the phase of the modulated vector in response to a phase control signal. A varactor coupled across the first input and the second input of the amplification stage adjusts the capacitance between the first input and the second input in response to a capacitance control signal.

Abstract: An aerosol hairspray product with a spray device and a pressurizable container having a container wall which encloses a reservoir for storing a compressed gas propellant and a hairspray composition. The hairspray composition can be ethanol-based or ethanol-free. The spray properties of the product, including the spray rate and median droplet size, can be maintained throughout the lifetime of the container.

Abstract: This disclosure describes meltblown methods, assemblies, and systems for polymer production. In one such implementation, a meltblown system provides improved uniform output and reduction of fiber size given certain polymer material and production rate. In certain meltblown implementations, the equipment may be ready and quickly swapped while provided in hot standby mode such that the maintenance down time is minimized. The disclosed meltblown equipment may include a polymer beam and air chamber and a die tip assembly. The die tip assembly, in certain embodiments, may quickly be attached onto or removed from the polymer beam and air chamber. In preferred embodiments, the meltblown system includes a single input (e.g., a specific type of polymer material). The meltblown system includes some tapered structures that facilitate polymer flow. The assembly mechanisms used in the meltblown system enables cleaning of the polymer distribution components with each use.

Abstract: A spraying apparatus, used for connecting a high-pressure liquid supply device to receive a high-pressure liquid conveyed by the high-pressure liquid supply device, includes a container, a delivery pipe, a liquid-mixing fitting, a pressurized fitting and a foam-generating element. The container, used for accommodating a detergent. The liquid-mixing fitting is connected with the high-pressure liquid supply device. When the high-pressure liquid flows by, the detergent is inhaled to the liquid-mixing fitting via the delivery pipe to mix the high-pressure liquid for forming a detergent mixture. An inner wall of the pressurized fitting is furnished with at least one helical groove for pressurizing the detergent mixture to form a pressurized detergent mixture. As the pressurized detergent mixture flows by the foam-generating element, a plurality of cleaning foams are formed for enhance cleaning effect.