Patents by Inventor Lee D. OLIVER

Lee D. OLIVER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polyvalent chimeric OspC vaccinogen and diagnostic antigen
    Patent number: 10466240
    Abstract: Chimeric polyvalent recombinant proteins for use as vaccines and diagnostics for Lyme disease (e.g. in canines and humans) are provided. The chimeric proteins comprise epitopes of the loop 5 region and/or the alpha helix 5 region of outer surface protein C (OspC) types and/or OspE types. The OspC types may be associated with mammalian Borrelia infections.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: November 5, 2019
    Assignee: Virginia Commonwealth University
    Inventors: Richard T. Marconi, Christopher Earnhart, Lee D. Oliver
  • Stage specific diagnostic antigens, assay and vaccine for lyme disease
    Patent number: 10086057
    Abstract: Stage-specific Borrelia antigens for diagnosing, treating and/or preventing Lyme disease are provided. The antigens include chimeric Borrelia antigen constructs and mutant recombinant proteins comprising OspC and OspE epitopes, respectively. The antigens are used in multiprotein assays that differentiate early, middle and late stage infection, and/or in vaccine preparations.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: October 2, 2018
    Assignee: Virginia Commonwealth University
    Inventors: Richard T. Marconi, Lee D. Oliver
  • POLYVALENT CHIMERIC OSPC VACCINOGEN AND DIAGNOSTIC ANTIGEN
    Publication number: 20180275126
    Abstract: Chimeric polyvalent recombinant proteins for use as vaccines and diagnostics for Lyme disease (e.g. in canines and humans) are provided. The chimeric proteins comprise epitopes of the loop 5 region and/or the alpha helix 5 region of outer surface protein C (OspC) types and/or OspE types. The OspC types may be associated with mammalian Borrelia infections.
    Type: Application
    Filed: May 11, 2018
    Publication date: September 27, 2018
    Inventors: Richard T. MARCONI, Christopher EARNHART, Lee D. OLIVER
  • STAGE SPECIFIC DIAGNOSTIC ANTIGENS, ASSAY AND VACCINE FOR LYME DISEASE
    Publication number: 20170252422
    Abstract: Stage-specific Borrelia antigens for diagnosing, treating and/or preventing Lyme disease are provided. The antigens include chimeric Borrelia antigen constructs and mutant recombinant proteins comprising OspC and OspE epitopes, respectively. The antigens are used in multiprotein assays that differentiate early, middle and late stage infection, and/or in vaccine preparations.
    Type: Application
    Filed: October 8, 2015
    Publication date: September 7, 2017
    Inventors: Richard T. Marconi, Lee D. Oliver
  • POLYVALENT CHIMERIC OSPC VACCINOGEN AND DIAGNOSTIC ANTIGEN
    Publication number: 20160097768
    Abstract: Chimeric polyvalent recombinant proteins for use as vaccines and diagnostics for Lyme disease (e.g. in canines and humans) are provided. The chimeric proteins comprise epitopes of the loop 5 region and/or the alpha helix 5 region of outer surface protein C (OspC) types and/or OspE types. The OspC types may be associated with mammalian Borrelia infections.
    Type: Application
    Filed: October 8, 2015
    Publication date: April 7, 2016
    Inventors: Richard T. MARCONI, Christopher EARNHART, Lee D. OLIVER