Patents by Inventor Lee D. Spate

Lee D. Spate has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MEDIUM SUPPLEMENT TO INCREASE THE EFFICIENCY OF OOCYTE MATURATION AND EMBRYO CULTURE IN VITRO
    Publication number: 20240076611
    Abstract: The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive medium or supplement comprises three growth factors, namely, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF-1) in a synergistic combination. Methods for oocyte and embryo culture are also provided.
    Type: Application
    Filed: July 24, 2023
    Publication date: March 7, 2024
    Applicant: The Curators of the University of Missouri
    Inventors: Ye Yuan, Lee D. Spate, Randall S. Prather, R. Michael Roberts
  • Medium supplement to increase the efficiency of oocyte maturation and embryo culture in vitro
    Patent number: 11753622
    Abstract: The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive medium or supplement comprises three growth factors, namely, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF-1) in a synergistic combination. Methods for oocyte and embryo culture are also provided.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: September 12, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Ye Yuan, Lee D. Spate, Randall S. Prather, R. Michael Roberts
  • MEDIUM SUPPLEMENT TO INCREASE THE EFFICIENCY OF OOCYTE MATURATION AND EMBRYO CULTURE IN VITRO
    Publication number: 20210017490
    Abstract: The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive medium or supplement comprises three growth factors, namely, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF-1) in a synergistic combination. Methods for oocyte and embryo culture are also provided.
    Type: Application
    Filed: June 3, 2020
    Publication date: January 21, 2021
    Applicant: The Curators of the University of Missouri
    Inventors: Ye Yuan, Lee D. Spate, Randall S. Prather, R. Michael Roberts
  • MEDIUM SUPPLEMENT TO INCREASE THE EFFICIENCY OF OOCYTE MATURATION AND EMBRYO CULTURE IN VITRO
    Publication number: 20170258495
    Abstract: The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive medium or supplement comprises three growth factors, namely, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF-1) in a synergistic combination. Methods for oocyte and embryo culture are also provided.
    Type: Application
    Filed: February 28, 2017
    Publication date: September 14, 2017
    Applicant: The Curators of the University of Missouri
    Inventors: Ye Yuan, Lee D. Spate, Randall S. Prather, R. Michael Roberts