Abstract: A neurological screening device and method for assessing brain dysfunction of a subject including a projection apparatus configured to project an image onto retinas of a subject, detectors configured to capture light reflected from the retinas, the reflected light indicating a fixation of the eyes, a controller configured to generate baseline cognitive performance data based at least in part on a presence or absence of fixation, cause output of a plurality of assessment images on displays of the neurological screening device, the plurality of assessment images corresponding to a cognitive assessment configured to stress the frontal lobe of the subject, generate stressed cognitive performance data based at least in part on a presence or absence of fixation during the cognitive assessment, and determine brain dysfunction of the subject based at least in part on the baseline cognitive performance data and the stressed cognitive performance data.

Abstract: A neurological screening device and method for assessing brain dysfunction of a subject including a projection apparatus configured to project an image onto retinas of a subject, detectors configured to capture light reflected from the retinas, the reflected light indicating a fixation of the eyes, a controller configured to generate baseline cognitive performance data based at least in part on a presence or absence of fixation, cause output of a plurality of assessment images on displays of the neurological screening device, the plurality of assessment images corresponding to a cognitive assessment configured to stress the frontal lobe of the subject, generate stressed cognitive performance data based at least in part on a presence or absence of fixation during the cognitive assessment, and determine brain dysfunction of the subject based at least in part on the baseline cognitive performance data and the stressed cognitive performance data.

Abstract: System for transcription of audio captured during in-person and/or remote (video-conferencing) events using speech to text (STT) technology. Each participant is associated with unique audio capturing device (microphone for in-person event; device utilized to partake in event (e.g., phone, computer) for remote event). Separate audio stream is captured for each participant and parameters about the participants are defined. Audio streams are synchronized with respect to each other for event. Bleeding of microphones is addressed by comparing equalized signal strengths and muting speech for microphones not having strongest signal strength. Synchronized audio streams are provided to STT engine that provides corresponding text back. Text is identified with stream it came from and time within event it occurred. System displays text in order based on event time and provides identification information and ability to edit/annotate. Operator edits/annotates translated text as required.

Abstract: An electronic system for transcription of audio captured during an event using a plurality of microphones, one for each person possibly speaking during the event. A frequency for each microphone in an environment is determined prior to use. During the event audio is received from each microphone. A signal strength of the audio captured by each microphone is captured and utilized along with the frequency for each microphone to determine which microphone is associated with the person speaking. Record audio from microphone determined to be associated with the person speaking and ignore audio from other microphones. Provide recorded audio to a voice to text engine and receive corresponding text from the voice to text engine and present the text to an operator who can modify in real time or after the event. The corresponding text includes confidence levels association with the translation identifies the person speaking in some fashion.

Abstract: A neurological screening device and method for assessing brain dysfunction of a subject including a projection apparatus configured to project an image onto retinas of a subject, detectors configured to capture light reflected from the retinas, the reflected light indicating a fixation of the eyes, a controller configured to generate baseline cognitive performance data based at least in part on a presence or absence of fixation, cause output of a plurality of assessment images on displays of the neurological screening device, the plurality of assessment images corresponding to a cognitive assessment configured to stress the frontal lobe of the subject, generate stressed cognitive performance data based at least in part on a presence or absence of fixation during the cognitive assessment, and determine brain dysfunction of the subject based at least in part on the baseline cognitive performance data and the stressed cognitive performance data.

Abstract: A device and method for measuring saccadic latency, including a light source positioned within a housing that projects a beam of light through a window of the housing and onto a retina of a subject, lights disposed on or in an external surface of the housing, detectors positioned within the housing and configured to detect light reflected from the retina of the subject through the window of the housing, and a controller that causes output of a sequence of cues and determines a time interval corresponding to a delay between output of a cue in the sequence of cues and either fixation or loss of fixation by the subject, the fixation or loss of fixation being determined based at least in part on the light reflected from the retina of the subject.

Abstract: A device can include a body having a top surface, an opposing bottom surface, a first face and an opposing second face. The first face can have an opening therein. A light source can be positioned within the body. The light source can be configured to create a beam of polarized light. At least a portion of the beam of polarized light can be directed outside of the body through the opening in the front face. At least one polarization sensitive detector can be positioned within the body. At least one light can be positioned on or in the first face. At least one target can be configured to be visible through the opening in the front face of the device. The lights and the target can be configured to illuminate in a predetermined manner or pattern.

Abstract: A system for performing quasi-elastic light scattering and fluorescent ligand scanning on a subject's eye includes a light source configured to transmit light toward the subject's eye, a lens configured to focus light sent from the source and scattered by the subject's eye, a measurement reflector disposed to receive at least a portion of the focused light and configured to reflect a first portion of the received light, a camera configured and disposed to receive the first portion of the received light and configured to provide indicia of an image corresponding to the first portion of the received light, and a processor coupled to the camera and configured to analyze intensities of light in the image to determine a location of a reference point corresponding to an interface of a portion of the eye.

Abstract: The invention features a method of diagnosing or providing a prognosis regarding the state of Transmissible Spongiform Encephalopathies (TSEs) in a mammal by contacting a target tissue or other environmental sample with a detectable compound, which binds to a non-amyloid form of a disease specific prion (PrP-d). An increase in binding of the compound to the target tissue or environmental sample compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing TSE, or that the sample is contaminated with TSE-infected material.

Abstract: The invention provides a method of diagnosing, prognosing, staging, and/or monitoring a mammalian amyloidogenic disorder or a predisposition thereto by detecting a protein or polypeptide aggregate in the cortical and/or supranuclear regions of an ocular lens of the mammal.

Abstract: The invention features a method of diagnosing or providing a prognosis regarding the state of Alzheimer's Disease in a mammal by contacting an ocular tissue with a detectably-labeled compound, which binds to an amyloid protein. An increase in binding of the compound to the ocular tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.

Abstract: Described are methods for the identification of agents useful in the treatment or prevention of cataracts. Also described are methods for the identification of agents that may inadvertently promote or accelerate the formation of cataracts, and methods of treating or preventing injuries to or diseases of the ocular lens, retina and/or macular. More specifically, the invention describes methods for the identification of pharmacological agents useful in treating cataracts by inhibiting the cross-linking of eye lens proteins.