Patents by Inventor Lee Greenberger

Lee Greenberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LNA antisense oligonucleotides for the modulation of Myc expression
    Patent number: 9506060
    Abstract: The disclosure relates to oligonucleotide compounds (oligomers) that target Myc mRNA in a cell, leading to reduced expression of Myc. Reduction of Myc expression is beneficial for the treatment of certain disorders, such as hyperproliferative disorders (e.g., cancer). The disclosure provides therapeutic compositions comprising oligomers and methods for modulating the expression of Myc using said oligomers, including methods of treatment.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: November 29, 2016
    Assignees: DANA-FARBER CANCER INSTITUTE, INC., ENZON PHARMACEUTICALS, INC.
    Inventors: Rajanikanth Bandaru, Yixian Zhang, Zhengxing Qu, Lee Greenberger, Christopher Ott, James Elliott Bradner
  • LNA ANTISENSE OLIGONUCLEOTIDES FOR THE MODULATION OF MYC EXPRESSION
    Publication number: 20160024495
    Abstract: The disclosure relates to oligonucleotide compounds (oligomers) that target Myc mRNA in a cell, leading to reduced expression of Myc. Reduction of Myc expression is beneficial for the treatment of certain disorders, such as hyperproliferative disorders (e.g., cancer). The disclosure provides therapeutic compositions comprising oligomers and methods for modulating the expression of Myc using said oligomers, including methods of treatment.
    Type: Application
    Filed: February 15, 2013
    Publication date: January 28, 2016
    Inventors: Rajanikanth Bandaru, Yixian Zhang, Zhengxing Qu, Lee Greenberger, Christopher Ott, James Elliott Bradner
  • SUBSTITUTED PYRIMIDINE KINASE INHIBITORS
    Publication number: 20070254896
    Abstract: The present invention is directed to substituted pyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating a chronic or acute protein kinase mediated disease, disorder or condition.
    Type: Application
    Filed: March 23, 2007
    Publication date: November 1, 2007
    Inventors: Jeannene Butler, Peter Connolly, Angel Fuentes-Pesquera, Lee Greenberger, Shenlin Huang, Kenneth LaMontagne, Ronghua Li, Guozhang Xu
  • Hemiasterlin affinity probes and their uses
    Publication number: 20070026478
    Abstract: Photoaffinity probes are provided that are based hemiasterlin and derivative compounds thereof. Use of these probes to identity ending sites for these and other drugs, particularly anti-tubulin drugs, are also provided as are methods for identifying new drugs (e.g., new anti-tubulin drugs) that bind to these binding sites.
    Type: Application
    Filed: November 21, 2003
    Publication date: February 1, 2007
    Applicant: WYETH
    Inventors: Lee Greenberger, Malathi Hari, Maria Nunes, Semiramis Ayral-Kaloustian, Arie Zask, Joseph Wooters
  • Use of an epidermal growth factor receptor kinase inhibitor (EGFR) in gefitinib resistant patients
    Publication number: 20060235046
    Abstract: This invention discloses method of treating or inhibiting cancer in a human having at least one of an Exon 19 del E746-A750 and/or an Exon 21 point mutation comprising administering to said human gefitinib and/or iressa alone or in combination with other cytotoxic agents or chemotherapeutic agents and an effective amount of EGFR kinase inhibitor.
    Type: Application
    Filed: April 12, 2006
    Publication date: October 19, 2006
    Applicant: Wyeth
    Inventors: Charles Zacharchuk, Susan Quinn, Patricia Martins, Lee Greenberger, Ante Lundberg
  • Use of a combination of an epidermal growth factor receptor kinase inhibitor and cytotoxic agents for treatment and inhibition of cancer
    Publication number: 20050026933
    Abstract: This invention discloses a method of treating or inhibiting cancer in a mammal in need thereof which comprises administering to said mammal an effective amount of a cytotoxic agent and an EGFR kinase inhibitor.
    Type: Application
    Filed: July 28, 2004
    Publication date: February 3, 2005
    Applicant: Wyeth Holdings Corporation
    Inventors: Lee Greenberger, Carolyn Discafani-Marro, Philip Frost