Abstract: Various embodiments of a metered dose inhaler are disclosed. The inhaler includes a container and a metering valve connected to the container. The metering valve includes a valve housing having first and second ends and a metering valve stem that extends through the first end, a metering chamber, and the second end of the valve housing. A first portion of the metering valve stem is disposed through a diaphragm opening of a diaphragm that is disposed at least partially within the first end of the housing and forms a dynamic seal with the diaphragm, and a second portion of the metering valve stem is disposed through a tank seal opening of a tank seal that is disposed at least partially within the second end of the housing and forms a dynamic seal with the tank seal. At least one of the diaphragm or tank seal includes a polytetrafluoroethylene material.

Abstract: A metered dose inhaler valve (26) has a reservoir portion (37) for assembly with a canister (14) for receiving a pressurised formulation of medicament and propellant, a metering valve body (96) defining a metering chamber, and a metering valve stem (24) having an outlet (56) and being axially moveable within the body. The stem moves between a first position in which the chamber is in fluid communication with the canister, and a second position in which the chamber is in fluid communication with the valve stem outlet. A metering valve seal is defined by the valve body and includes an opening through which the stem passes to form a dynamic seal between the stem and at least one of the outside atmosphere and the pressurized canister, where the opening is adapted to be stretched wider by the stem passing through it than it would be absent the valve stem.

Abstract: Various embodiments of a storage and dispensing apparatus for a pressurised metered dose inhaler and a method of utilizing such apparatus are disclosed. The apparatus includes a canister containing a mixture of a propellant and a therapeutic agent, an electronically actuated valve, and a controller configured to control the valve. The controller is further configured to actuate the valve to agitate the mixture within the canister, and actuate the valve to release a dose of the agitated mixture from the canister, where actuating the valve to agitate and actuating the valve to release a dose are discrete.