Abstract: A needle assembly includes a housing having proximal and distal ends, an IV cannula projecting distally from the housing, and an IV shield having an engagement. The housing has a shield seat and the IV cannula has a distal tip. The IV shield has a pre-use position where the IV shield covers the distal tip of the IV cannula and the engagement is disengaged from the shield seat, and a use position where the engagement is engaged with the shield seat and the IV shield is adapted to move between a non-shielded position, in which the distal tip is exposed, and a shielded position, in which the distal tip is shielded by the IV shield.

Abstract: A needle assembly includes a housing having proximal and distal ends, an IV cannula projecting distally from the housing, and an IV shield having an engagement. The housing has a shield seat and the IV cannula has a distal tip. The IV shield has a pre-use position where the IV shield covers the distal tip of the IV cannula and the engagement is disengaged from the shield seat, and a use position where the engagement is engaged with the shield seat and the IV shield is adapted to move between a non-shielded position, in which the distal tip is exposed, and a shielded position, in which the distal tip is shielded by the IV shield.

Abstract: A needle assembly includes a housing having proximal and distal ends, an IV cannula projecting distally from the housing, and an IV shield having an engagement. The housing has a shield seat and the IV cannula has a distal tip. The IV shield has a pre-use position where the IV shield covers the distal tip of the IV cannula and the engagement is disengaged from the shield seat, and a use position where the engagement is engaged with the shield seat and the IV shield is adapted to move between a non-shielded position, in which the distal tip is exposed, and a shielded position, in which the distal tip is shielded by the IV shield.

Abstract: A fluid collection assembly and method for use thereof is provided including a barrel with a plunger rod slidably inserted is disclosed. The assembly and method are particularly useful in the collection of arterial blood. The plunger rod includes a proximal portion, a distal portion with a stopper, and a breakable connector between the proximal and distal portions. In use, the assembly is primed with a liquid anticoagulant, the breakable connection is broken, and a fluid sample is collected with the arterial pressure causing the distal portion of the plunger rod to travel in a proximal direction along the barrel and contact an annular flange extending within the barrel. After collection, a tip cap can be applied to the assembly to prevent any spillage of the fluid sample during handling, storage, and transportation.

Abstract: A fluid collection assembly and method for use thereof is provided including a barrel with a plunger rod slidably inserted is disclosed. The assembly and method are particularly useful in the collection of arterial blood. The plunger rod includes a proximal portion, a distal portion with a stopper, and a breakable connector between the proximal and distal portions. In use, the assembly is primed with a liquid anticoagulant, the breakable connection is broken, and a fluid sample is collected with the arterial pressure causing the distal portion of the plunger rod to travel in a proximal direction along the barrel and contact an annular flange extending within the barrel. After collection, a tip cap can be applied to the assembly to prevent any spillage of the fluid sample during handling, storage, and transportation.

Abstract: A needle assembly includes a housing having proximal and distal ends, an IV cannula projecting distally from the housing, and an IV shield having an engagement. The housing has a shield seat and the IV cannula has a distal tip. The IV shield has a pre-use position where the IV shield covers the distal tip of the IV cannula and the engagement is disengaged from the shield seat, and a use position where the engagement is engaged with the shield seat and the IV shield is adapted to move between a non-shielded position, in which the distal tip is exposed, and a shielded position, in which the distal tip is shielded by the IV shield.

Abstract: It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a disorder mediated by VCAM-1. Examples of inflammatory disorders that are mediated by VCAM-1 include, but are not limited to arthritis, asthma, dermatitis, cystic fibrosis, post transplantation late and chronic solid organ rejection, multiple sclerosis, systemic lupus erythematosis, inflammatory bowel diseases, autoimmune diabetes, diabetic retinopathy, rhinitis, ischemia-reperfusion injury, post-angioplasty restenosis, chronic obstructive pulmonary disease (COPD), glomerulonephritis, Graves disease, gastrointestinal allergies, conjunctivitis, atherosclerosis, coronary artery disease, angina and small artery disease.

Abstract: The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the application.

Abstract: Thioketals and thioethers are provided that inhibit the expression of VCAM-1, and which can be used in the treatment of VCAM-1 mediated diseases including inflammatory disorders, cardiovascular diseases, occular diseases, autoimmune diseases, neurological disorders, and cancer. The compounds also can be used to treat hyperlipidemia and/or hypercholesterolemia.