Patents by Inventor Lee J. Silverberg

Lee J. Silverberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • S-OXIDES OF 2,3-DIARYL-2,3-DIHYDRO-4H-1,3-THIAZIN-4-ONES AND 2,3-DIARYL-1,3-THIAZEPAN-4-ONES AND METHODS FOR MAKING
    Publication number: 20220259165
    Abstract: A compound with the following general formula and a general method of making this compound are provided: R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are each independently selected from the group that includes hydrogen, halogen, nitro, cyano, amido, pyridyl, alkyl, aryl, alkoxy, cycloalkyl, heteroalkyl, heterocyclyl, aralkyl, heteroaryl and heteroaralkyl.
    Type: Application
    Filed: May 8, 2020
    Publication date: August 18, 2022
    Inventor: Lee J. Silverberg
  • 2,3-DIARYL-1,3-THIAZEPAN-4-ONES COMPOUNDS AND METHODS FOR MAKING
    Publication number: 20220227723
    Abstract: A compound with the following general formula (I) and a general method for making this compound are provided, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15 and R16 are each independently selected from the group that includes H, halogen, nitro, cyano, alkyl, aryl, alkoxy, cycloalkyl, heteroalkyl, heterocyclyl, aralkyl, heteroaryl and heteroaralkyl.
    Type: Application
    Filed: May 8, 2020
    Publication date: July 21, 2022
    Inventor: Lee J. Silverberg
  • 2,3-Diaryl-2,3-Dihydro-4H-1,3-Thiazin-4-One Compounds and Methods for Making
    Publication number: 20220213046
    Abstract: A compound with the following general formula (I) and a general method of making this compound are provided. R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are each independently selected from the group that includes H, halogen, nitro, cyano, amido, pyridyl, alkyl, aryl, acyl, alkoxy, cycloalkyl, heteroalkyl, heterocyclyl, aralkyl, heteroaryl and heteroaralkyl.
    Type: Application
    Filed: May 21, 2020
    Publication date: July 7, 2022
    Applicant: The Penn State Research Foundation
    Inventors: Lee J. Silverberg, John Tierney
  • Process of preparing etoposide phosphate and etoposide
    Patent number: 5688926
    Abstract: Etoposide phosphate is prepared by coupling dibenzyl 4'-demethyl-4-epipodophyllotoxin-4'-phosphate with 2,3-di-O-benzyl-4,6-O-ethylidene-.alpha.,.beta.-D-glucopyranose in a solvent and subsequently removing the protecting groups. The tetra-benzyl protected etoposide phosphate is recrystallized from methanol or directly crystallized from acetonitrile by adding methanol to yield substantially the pure C-1"-.beta. form. The benzyl protecting groups are simultaneously removed by hydrogenation to produce etoposide phosphate in high yields. In a further embodiment, etoposide phosphate is treated with a phosphatase enzyme to yield etoposide.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 18, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Lee J. Silverberg, Purushotham Vemishetti, John L. Dillon, Jr., John J. Usher
  • Process of preparing etoposide phosphate and etoposide
    Patent number: 5459248
    Abstract: Etoposide phosphate is prepared by coupling dibenzyl 4'-demethyl-4-epipodophyllotoxin-4'-phosphate with 2,3-di-O-benzyl-4,6-O-ethylidene-.alpha.,.beta.-D-glucopyranose in a solvent and subsequently removing the protecting groups. The tetra-benzyl protected etoposide phosphate is recrystallized from methanol or directly crystallized from acetonitrile by adding methanol to yield substantially the pure C-1"-.beta. form. The benzyl protecting groups are simultaneously removed by hydrogenation to produce etoposide phosphate in high yields. In a further embodiment, etoposide phosphate is treated with a phosphatase enzyme to yield etoposide.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: October 17, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Lee J. Silverberg, Purushotham Vemishetti, John L. Dillon, Jr., John J. Usher