Abstract: The present invention relates to engineered microorganisms, wherein the engineered microorganisms comprise a therapeutic molecule and a modified pks island.

Abstract: Provided herein are compounds that activate IRE1/XBP1s, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject having a disease or disorder that may be ameliorated by increasing IRE1/XBP1s activity.

Abstract: An interfacing structure for a mask system includes a cushion component adapted to contact the patient's face in use and a cushion-to-frame component provided to the cushion component. The cushion-to-frame component is structured to secure the cushion component to a mask frame of the mask system. The cushion-to-frame component includes a cushion side adapted to interface with the cushion component and a frame side adapted to interface with the mask frame. The cushion side includes a platform to engage and support the cushion component. The platform provides an engagement surface to engage the cushion component and inner and outer flanges provided to opposing ends of the platform to guide, support and/or retain the cushion component on the platform.

Abstract: The present invention is directed to an electrodepositable coating composition comprising an electrodepositable binder comprising an ionic salt group-containing film-forming polymer comprising active hydrogen functional groups, and a blocked polyisocyanate curing agent; a solubilized bismuth catalyst; and a guanidine; wherein the electrodepositable coating composition has a weight ratio of bismuth metal from the solubilized bismuth catalyst to guanidine of from 1.00:0.071 to 1.0:2.1 and/or a molar ratio of bismuth metal to guanidine of from 1.0:0.25 to 1.0:3.0. Also disclosed are methods of treating electrodepositable coating compositions, methods for making electrodepositable coating compositions, systems for coating a metal substrate, coatings, coated substrates, and methods of coating a substrate.

Abstract: Systems and techniques are provided for vehicle safety technologies. An example method can include detecting, based on sensor data captured by an autonomous vehicle (AV), an emergency event associated with the AV; and in response to detecting the emergency event, generating information about the emergency event based on the sensor data and sending, to an emergency responder, a wireless signal including a request for help from the emergency responder and the information about the emergency event; and based on a determination that the emergency responder is within a threshold proximity to the AV, providing additional data associated with the emergency event to the emergency responder and/or one or more devices associated with the emergency responder.

Abstract: A vent assembly is configured to discharge gas washout from a patient interface that is configured to receive a pressurized flow of breathable gas from a positive airway pressure device. The vent assembly includes a vent base configured to be attached to the patient interface and comprising a plurality of coplanar openings and a hydrophilic material positioned adjacent to the coplanar openings. The hydrophilic material is configured to wick water near the plurality of coplanar openings and/or capture moisture from a gas washout flow adjacent to the plurality of coplanar openings. In addition, the hydrophilic material is configured to release the accumulated moisture and/or water to the pressurized flow of breathable gas for breathing by the patient when the patient inhales.

Abstract: A nasal assembly for delivering breathable gas to a patient includes a frame having lateral connector, a cushion with a pair of nozzles, and a clip to secure the cushion to the frame. The frame includes a vent channel and a plurality of vent holes. The frame/cushion includes structure (lugs/cut outs) to prevent the assembly of an unvented frame with an unvented cushion, for safety purposes. The frame includes cored portions that interface with corner lugs provided on the cushion. A patient interface includes a frame, a cushion (nasal mask, nasal-oro mask, nozzles, etc.) and a vent assembly including a pattern of vent holes including at least two rows.

Abstract: Systems and methods for an autonomous vehicle interactive experience platform. An interactive experience platform is provided that utilizes vehicle sensors, as well as in-cabin hardware and software, and fleet management information, to provide a unique and personalized autonomous vehicle interactive experience. The interactive experience platform can use external factors to influence in-experience elements. In some examples, the interactive experience platform can use in-experience events to influence autonomous vehicle behavior.

Abstract: A patient interface is configured to deliver a pressurized flow of respiratory gas to a patient's airways. The patient interface includes a cushion and shell assembly with a cushion portion mounted on a shell portion that is more rigid than the cushion portion. The cushion portion is configured to sealingly engage the patient's face and has a vent opening. The shell portion includes a plurality of headgear connectors. The patient interface further includes a gas washout vent assembly configured to be positioned within the vent opening of the cushion portion. The gas washout vent assembly includes a main body configured to be secured to the cushion portion, a porous body, and an outer cover with a plurality of openings. The main body at least partially houses the porous body and the outer cover.

Abstract: An interlocking wrap for covering an outer surface of an object provides desirable qualities to complex tube shapes using a flat piece of material. The wrap may cover tubes, handles, rods, or hoops, in their many examples. Existing adhesive technologies applied to the back of the material, combined with the formation of the material into a series of three or more offset tabs that interlock when folded together in the prescribed alternating order at their meeting points, creates a cover that is pleasing to the eye, protective, and durable to frictional use. The tabs overlap one over the next in similar fashion to a zipper or a braid, only leaving the bottom tab exposed to use.

Abstract: A respiratory mask assembly for use with a patient, and that is suited for use with children ranging in age from about 2-7 years, includes a flexible patient interface structure arranged to interface with and deliver air to the patient's nose, the patient interface structure including cylindrical protrusions extending from respective opposite sides of the patient interface structure adjacent the patient's nares; a frame configured to support the patient interface structure, the frame including a pair of cylinders, each cylinder configured to receive a respective cylindrical protrusion of the patient interface structure; headgear arranged for releasable attachment to the frame; an air delivery tube connected to either one of the cylindrical protrusions; and a plug connected to the other one of the cylindrical protrusions.

Abstract: Irrigation nozzles are provided that irrigate a full circle coverage area with different maximum throw radiuses. The nozzle may include two bodies, one nested within the other, that acting together form the full circle coverage area. The two bodies collectively define an annular exit orifice with one of the bodies defining the inner radius and the other body defining the outer radius. A flow restrictable inlet may be used to adjust flow through the nozzle and to adjust the maximum throw radius. The nozzle may also include a flow reduction valve to reduce the throw radius from a maximum distance and may be adjusted by actuation of an outer wall of the nozzle. A deflector for use with an irrigation nozzle is also provided.

Abstract: A nozzle is provided having a low precipitation rate and uniform fluid distribution to a desired arcuate span of coverage. The nozzle has an inflow port having a shape corresponding to the desired arc of coverage and a size for effecting a low precipitation rate. The nozzle also has a deflector surface with a water distribution profile including ribs for subdividing the fluid into multiple sets of fluid streams. There are at least two fluid streams for distant and close-in irrigation to provide relatively uniform distribution and coverage. The nozzle may be a unitary, one-piece, molded nozzle body including a mounting portion, an inflow port, and a deflector portion.

Abstract: Systems and methods of controlling outputs of infrared heaters used to join a first part to a second part, and a component made thereby. Upper and lower nests hold the first and second parts, respectively. A movable heating platen has infrared heaters on opposite surfaces. Imaging sensors have fields of view encompassing heated portions of the first and second parts, respectively, when the platen is retracted away from an area between the upper and lower nests. A controller causes the upper and lower nests to move while causing the platen to extend into and retract away from the area between the upper and lower nests. The first imaging sensor takes a first image of the heated portions of the first part, which causes an adjustment to be made to an output of the infrared heaters in a subsequent welding cycle.

Abstract: Plant growth structures and components of plant growth structures. The plant growth structure components provide the ability to customize the plant growth structure to suit the needs of different types of plants. The plant growth structures also provide improved water flow to the plants and a high density of plants in a relatively small growing area.

Abstract: A respiratory mask assembly for use with a patient, and that is suited for use with children ranging in age from about 2-7 years, includes a flexible patient interface structure arranged to interface with and deliver air to the patient's nose, the patient interface structure including cylindrical protrusions extending from respective opposite sides of the patient interface structure adjacent the patient's nares; a frame configured to support the patient interface structure, the frame including a pair of cylinders, each cylinder configured to receive a respective cylindrical protrusion of the patient interface structure; headgear arranged for releasable attachment to the frame; an air delivery tube connected to either one of the cylindrical protrusions; and a plug connected to the other one of the cylindrical protrusions.

Abstract: A nasal assembly for delivering breathable gas to a patient includes a frame having an integrally formed first connector portion. A nozzle assembly includes a gusset or base portion and a pair of nozzles. At least one inlet conduit is structured to deliver breathable gas into the frame and nozzle assembly for breathing by the patient. A pair of second connector portions are removably and rotatably connected to respective first connector portions of the frame and are in communication with respective inlet conduits, e.g., directly or via angle connectors. A headgear assembly is removably connected to the pair of second connector portions and/or the angle connectors so as to maintain the frame and the nozzle assembly in a desired adjusted position on the patient's face.

Abstract: A nasal assembly for delivering breathable gas to a patient includes a frame having lateral connector, a cushion with a pair of nozzles, and a clip to secure the cushion to the frame. The frame includes a vent channel and a plurality of vent holes. The frame/cushion includes structure (lugs/cut outs) to prevent the assembly of an unvented frame with an unvented cushion, for safety purposes. The frame includes cored portions that interface with corner lugs provided on the cushion. A patient interface includes a frame, a cushion (nasal mask, nasal-oro mask, nozzles, etc.) and a vent assembly including a pattern of vent holes including at least two rows.

Abstract: Embodiments of the disclosure are directed to methods, apparatuses, computer-readable media, and systems for network monitoring of communication requests for authorization to an access device. One embodiment is directed at dual message model in a distributed environment with an electronic access device receiving a cancellation signal and generating and sending a reversal message with cancellation information embedded in the data elements of the reversal message to a processor computer, where the cancellation data may be read and saved by the processor computer before the authorization request message is forwarded to be authorized by an authorization entity. The method further comprises generating a cancellation message after the reversal message has processed, where the cancellation message is sent via a transport computer to clear and reconcile the authorization status of the cancelled authorization request with any necessary authorizing or regulatory entities in the network.

Abstract: A respiratory mask for continuous positive airway pressure treatment includes a cushion adapted to be positioned against the face of a patient. The cushion is configured in a gasket arrangement around an entrance to the airways of the patient. The cushion is constructed from a polyurethane foam and has a thickness of greater than about 5 mm.