Abstract: Disclosed herein is a novel monohydrate polymorphic form of S-nitrosocaptopril (CapNO), process for preparation, pharmaceutical compositions and method of treating pulmonary hypertension, hypertension, or congestive heart failure thereof. A process for the preparation of S-nitrosocaptopril crystalline form is provided which comprises the following steps: reacting captopril, sodium nitrite and EDTA-2Na.2H2O in 15±5 wt % saline, adjusting pH to precipitate the crystal, and recrystallizing S-nitrosocaptopril monohydrate crystalline. The crystals can be stably stored at 4° C. for at least 12 months.

Abstract: A design methodology is provided to fully automate the creation of multiple-personality programmable macros for use in metal/via programmable ICs. Programmability is achieved using programmable switches, each of which may include one or more metal traces and/or vias on one or more layers configured in series, in parallel, or in combination. Multiple overlapping switches may exist in the same location. That is, switches may be defined that use some of the same resources. Any one of the switches may be “turned on,” while the remaining switches remain turned off. As part of the design methodology, different nets or parts of an electrical circuit design are programmed by replacing the switches with hard connections that close the circuit, or with no connections so as to open the circuit, or cause the circuit to remain open. The methodology allows for sharing routing or programming resources to achieve optimize layout area usage.