Abstract: Provided herein are split reporter systems for detecting poly-ADP ribose polymerase activity in living systems. In some aspects, the split reporter systems comprise a first fusion protein comprising a first fragment of a reporter protein functionally linked to a first poly-ADP ribose binding moiety; and a second fusion protein comprising a second fragment of the reporter protein functionally linked to a second poly-ADP ribose binding moiety wherein the first and second fragments of the reporter protein are each non-functional and capable of recombining, optionally in the presence of a substrate, to form a functional reporter protein capable of producing a detectable signal. Also provided are methods of use thereof.

Abstract: Methods and systems for customizing a hearing device. The disclosed methods involve receiving an audio sample associated with a target entity, calculating at least one acoustic parameter from the audio sample, generating an audio stimulus using the at least one calculated acoustic parameter, presenting the audio stimulus to a user, receiving a response to the audio stimulus, and adjusting the hearing device based on an optimal parameter.

Abstract: Systems, methods, and apparatus for automatically parallelizing code segments are provided. For example, an environment includes a profiling agent, a parallelization agent, and a verification agent. The profiling agent executes a code segment and generates a profile of the executed code segment. The parallelization agent analyzes the code segment to determine whether a parallelizable portion is present in the code segment. When a parallelizable portion is present, the parallelization agent determines, based on the profile of the executed code segment, whether to parallelize the parallelizable portion of the code segment. If it is determined to parallelize the parallelizable portion of the code segment, the parallelization agent automatically parallelizes the parallelizable portion of the code segment. The verification agent verifies the functionality and/or correctness of the parallelized code segment.

Abstract: Methods and systems for customizing a hearing device. The disclosed methods involve receiving an audio sample associated with a target entity, calculating at least one acoustic parameter from the audio sample, generating an audio stimulus using the at least one calculated acoustic parameter, presenting the audio stimulus to a user, receiving a response to the audio stimulus, and adjusting the hearing device based on an optimal parameter.

Abstract: Methods and systems for mutating a network topology on which various containers run. The system includes a host controller to assign each of a plurality of hosts an unchanging public virtual IP address that maps to changing real IP address, a threat detection module to detect a mutation stimuli, and a management module configured to receive a mutation policy and execute the mutation policy to enact a container mutation upon the threat detection module detecting the mutation stimuli.

Abstract: Systems, methods, and apparatus for automatically parallelizing code segments are provided. For example, an environment includes a profiling agent, a parallelization agent, and a verification agent. The profiling agent executes a code segment and generates a profile of the executed code segment. The parallelization agent analyzes the code segment to determine whether a parallelizable portion is present in the code segment. When a parallelizable portion is present, the parallelization agent determines, based on the profile of the executed code segment, whether to parallelize the parallelizable portion of the code segment. If it is determined to parallelize the parallelizable portion of the code segment, the parallelization agent automatically parallelizes the parallelizable portion of the code segment. The verification agent verifies the functionality and/or correctness of the parallelized code segment.

Abstract: Systems, methods, and apparatus for automatically parallelizing code segments are provided. For example, an environment includes a profiling agent, a parallelization agent, and a verification agent. The profiling agent executes a code segment and generates a profile of the executed code segment. The parallelization agent analyzes the code segment to determine whether a parallelizable portion is present in the code segment. When a parallelizable portion is present, the parallelization agent determines, based on the profile of the executed code segment, whether to parallelize the parallelizable portion of the code segment. If it is determined to parallelize the parallelizable portion of the code segment, the parallelization agent automatically parallelizes the parallelizable portion of the code segment. The verification agent verifies the functionality and/or correctness of the parallelized code segment.

Abstract: Systems, methods, and apparatus for automatically parallelizing code segments are provided. For example, an environment includes a profiling agent, a parallelization agent, and a verification agent. The profiling agent executes a code segment and generates a profile of the executed code segment. The parallelization agent analyzes the code segment to determine whether a parallelizable portion is present in the code segment. When a parallelizable portion is present, the parallelization agent determines, based on the profile of the executed code segment, whether to parallelize the parallelizable portion of the code segment. If it is determined to parallelize the parallelizable portion of the code segment, the parallelization agent automatically parallelizes the parallelizable portion of the code segment. The verification agent verifies the functionality and/or correctness of the parallelized code segment.

Abstract: Methods and systems for providing secure computing environments. Features of the present invention use a plurality of integrated security controls to ensure security of a computing environment. More specifically, features of the present invention detect discrepancies between a node's behavior and a defined policy to identify and remedy malicious behavior.

Abstract: Methods and systems for providing secure computing environments. Features of the present invention use a plurality of integrated security controls to ensure security of a computing environment. More specifically, features of the present invention detect discrepancies between a node's behavior and a defined policy to identify and remedy malicious behavior.

Abstract: Hearing device configuration and hearing treatment using categorical perception; systems and methods for categorical perception based configuration of hearing devices and hearing treatment.

Abstract: Methods and systems for mutating a network topology on which various containers run. The system includes a host controller to assign each of a plurality of hosts an unchanging public virtual IP address that maps to changing real IP address, a threat detection module to detect a mutation stimuli, and a management module configured to receive a mutation policy and execute the mutation policy to enact a container mutation upon the threat detection module detecting the mutation stimuli.

Abstract: The present disclosure is directed to TSP1 and its coding RNA and cDNA as markers for cancer. Diagnostic methods and reagents for performing such assays also are described.

Abstract: Systems, methods, and apparatus for automatically parallelizing code segments are provided. For example, an environment includes a profiling agent, a parallelization agent, and a verification agent. The profiling agent executes a code segment and generates a profile of the executed code segment. The parallelization agent analyzes the code segment to determine whether a parallelizable portion is present in the code segment. When a parallelizable portion is present, the parallelization agent determines, based on the profile of the executed code segment, whether to parallelize the parallelizable portion of the code segment. If it is determined to parallelize the parallelizable portion of the code segment, the parallelization agent automatically parallelizes the parallelizable portion of the code segment. The verification agent verifies the functionality and/or correctness of the parallelized code segment.

Abstract: Methods and systems for providing secure computing environments. Features of the present invention use a plurality of integrated security controls to ensure security of a computing environment. More specifically, features of the present invention detect discrepancies between a node's behavior and a defined policy to identify and remedy malicious behavior.

Abstract: The present disclosure provides NAD analogs of the formula: wherein R1, n, and X1 are defined herein, useful for the identification of PARP target proteins and the amino acid sequence wherein the ribose group is attached to the target protein. Also, provided herein are methods of identifying target protein and amino acid sequences. Additionally, the present disclosure provides methods of identifying DNA sequences associated with specific chromatin proteins.

Abstract: The present disclosure described fusion proteins between ADP-ribose binding domains and antibody Fc domains. This new class of reagents has considerable value as detection agents in assays designed at examining the biology of ADP-ribose.

Abstract: Hearing device configuration and hearing treatment using categorical perception; systems and methods for categorical perception based configuration of hearing devices and hearing treatment.

Abstract: Systems and methods may be used to modify a controllable stimulus generated by a digital audio device in communication with a human user. An input signal is provided to the digital audio device. In turn, the digital audio device sends a stimulus based on that input signal to the human user, who takes an action, usually in the form of an output signal, to characterize the stimulus that the user receives, based on the user's perception. An algorithm, lookup table, or other procedure then determines a difference between the input signal and the output signal, and a perceptual model is constructed based at least in part on the difference. Thereafter, a new value for the parameter of the digital audio device is suggested based at least in part on the perceptual model. This process continues iteratively until the user's optimal device parameters are determined.

Abstract: Systems, methods, and apparatus for automatically parallelizing code segments are provided. For example, an environment includes a profiling agent, a parallelization agent, and a verification agent. The profiling agent executes a code segment and generates a profile of the executed code segment. The parallelization agent analyzes the code segment to determine whether a parallelizable portion is present in the code segment. When a parallelizable portion is present, the parallelization agent determines, based on the profile of the executed code segment, whether to parallelize the parallelizable portion of the code segment. If it is determined to parallelize the parallelizable portion of the code segment, the parallelization agent automatically parallelizes the parallelizable portion of the code segment. The verification agent verifies the functionality and/or correctness of the parallelized code segment.