Patents by Inventor Lee L. Rubin

Lee L. Rubin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240366627
    Abstract: The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject.
    Type: Application
    Filed: April 22, 2024
    Publication date: November 7, 2024
    Inventors: Lee L. Rubin, Amy J. Wagers, Amanda K. W. Gee, Feodor D. Price
  • Publication number: 20240228969
    Abstract: Disclosed herein are methods for generating satellite cells and compositions including satellite cells.
    Type: Application
    Filed: November 13, 2023
    Publication date: July 11, 2024
    Inventors: Lee L. Rubin, Feodor D. Price
  • Patent number: 11963964
    Abstract: The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject.
    Type: Grant
    Filed: June 7, 2021
    Date of Patent: April 23, 2024
    Assignee: President and Fellows of Harvard College
    Inventors: Lee L. Rubin, Amy J. Wagers, Amanda K. W. Gee, Feodor D. Price
  • Patent number: 11891625
    Abstract: The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF? signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: February 6, 2024
    Inventors: Derrick J. Rossi, Wataru Ebina, Morag Stewart, Paula Gutierrez-Martinez, Lee L Rubin, Lance Davidow
  • Patent number: 11859211
    Abstract: Disclosed herein are methods for generating satellite cells and compositions including satellite cells.
    Type: Grant
    Filed: November 23, 2022
    Date of Patent: January 2, 2024
    Assignee: President and Fellows of Harvard College
    Inventors: Lee L. Rubin, Feodor D. Price
  • Publication number: 20230098750
    Abstract: Disclosed herein are methods for generating satellite cells and compositions including satellite cells.
    Type: Application
    Filed: November 23, 2022
    Publication date: March 30, 2023
    Inventors: Lee L. Rubin, Feodor D. Price
  • Patent number: 11512291
    Abstract: Disclosed herein are methods for generating satellite cells and compositions including satellite cells.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: November 29, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Lee L. Rubin, Feodor D. Price
  • Patent number: 11426400
    Abstract: The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject.
    Type: Grant
    Filed: May 25, 2020
    Date of Patent: August 30, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Lee L. Rubin, Amanda Gee, Amy J. Wagers
  • Publication number: 20220054499
    Abstract: The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject.
    Type: Application
    Filed: June 7, 2021
    Publication date: February 24, 2022
    Inventors: Lee L. Rubin, Amy J. Wagers, Amanda K. W. Gee, Feodor D. Price
  • Publication number: 20220028488
    Abstract: Disclosed are systems and methods for utilizing electronic health record data (EHR) to group patients with diagnoses of a common disease of interested (e.g. Parkinson's disease) into phenotype clusters that share common clusters of other diagnosis codes (in addition to the Parkinson's diagnosis, for example). The phenotype clusters can be processed with genetic data to identify convergent genetic mutations within each phenotype cluster and output phenotypic-genomic clusters. Then, stem cells from the patients (e.g. iPSCs) may be differentiated into a desired cell type within each phenotypic-genomic cluster, and these differentiated cells may be assayed to identify defects in the various tissues types or organoids. Additionally, the differentiated cells can then be tested with candidate agents to determine whether the agents reverse the defective phenotypes identified in the differentiated tissues or organoids.
    Type: Application
    Filed: December 6, 2019
    Publication date: January 27, 2022
    Applicant: President and Fellows of Harvard College
    Inventors: Lee L. Rubin, Isaac S. Kohane, Scott Logan Lipnick
  • Patent number: 11026952
    Abstract: The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: June 8, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Lee L. Rubin, Amy J. Wagers, Amanda K. W. Gee, Feodor D. Price
  • Publication number: 20210004563
    Abstract: Provided herein are methods for analysis of target cells on a population or individual basis, including before and after contact with a stimulus in order to determine the effect of such stimulus on the target cells. Also provided are devices for performing such methods. The analysis methods involve identifying and measuring or tracking morphological changes that occur in target cells over a period of time. Tracking is accomplished using imaging systems capable of imaging target cells individually over a period of time either continuously or at discrete intervals of time.
    Type: Application
    Filed: July 20, 2020
    Publication date: January 7, 2021
    Applicants: President and Fellows of Harvard College, Nikon Corporation
    Inventors: Lee L. Rubin, Yasujiro Kiyota, Chieko Nakada, Keiichi Niikura, Kathleen L. Pfaff
  • Publication number: 20200352957
    Abstract: The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject.
    Type: Application
    Filed: May 25, 2020
    Publication date: November 12, 2020
    Inventors: Lee L. Rubin, Amanda Gee, Amy J. Wagers
  • Patent number: 10755078
    Abstract: Provided herein are methods for analysis of target cells on a population or individual basis, including before and after contact with a stimulus in order to determine the effect of such stimulus on the target cells. Also provided are devices for performing such methods. The analysis methods involve identifying and measuring or tracking morphological changes that occur in target cells over a period of time. Tracking is accomplished using imaging systems capable of imaging target cells individually over a period of time either continuously or at discrete intervals of time.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: August 25, 2020
    Assignees: President and Fellows of Harvard College, Nikon Corporation
    Inventors: Lee L. Rubin, Yasujiro Kiyota, Chieko Nakada, Keiichi Niikura, Kathleen L. Pfaff
  • Publication number: 20200248143
    Abstract: The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF? signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
    Type: Application
    Filed: April 21, 2020
    Publication date: August 6, 2020
    Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Derrick J. ROSSI, Wataru EBINA, Morag STEWART, Paula GUTIERREZ-MARTINEZ, Lee L. RUBIN, Lance DAVIDOW
  • Patent number: 10669528
    Abstract: The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF? signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: June 2, 2020
    Assignees: CHILDREN'S MEDICAL CENTER CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Derrick J. Rossi, Wataru Ebina, Morag Stewart, Paula Gutierrez-Martinez, Lee L. Rubin, Lance Davidow
  • Patent number: 10660902
    Abstract: The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: May 26, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: Lee L. Rubin, Amanda Gee, Amy J. Wagers
  • Publication number: 20190365777
    Abstract: The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject.
    Type: Application
    Filed: February 1, 2017
    Publication date: December 5, 2019
    Inventors: Lee L. Rubin, Amy J. Wagers, Amanda K. W. Gee, Feodor D. Price
  • Publication number: 20190367868
    Abstract: Disclosed herein are methods for generating functional motor neurons, compositions including functional motor neurons, and methods for screening for neurodegenerative diseases.
    Type: Application
    Filed: December 30, 2016
    Publication date: December 5, 2019
    Inventors: Lee L. Rubin, Alessandra Rigamonti
  • Publication number: 20190203180
    Abstract: Disclosed herein are methods for generating satellite cells and compositions including satellite cells.
    Type: Application
    Filed: March 8, 2019
    Publication date: July 4, 2019
    Inventors: Lee L. Rubin, Feodor D. Price