Patents by Inventor Lee Landeen

Lee Landeen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240018482
    Abstract: The present invention provides compositions comprising high densities of endothelial cells (such as human umbilical vein endothelial cells) in freezing media, methods of producing such compositions, and methods of using such compositions in the preparation of therapeutic endothelial cell compositions. Such compositions and methods provide numerous advantages including eliminating the requirement to remove cryopreservatives before administration of therapeutic endothelial cell compositions to human subjects and requiring minimal manipulations and human interventions before use in therapeutic methods.
    Type: Application
    Filed: August 10, 2021
    Publication date: January 18, 2024
    Inventors: Michael Daniel Ginsberg, Lee Landeen, Paul William Finnegan, John K Fraser
  • Publication number: 20180185446
    Abstract: The present invention provides a composition and method for inducing anti-apoptosis, anti-pyroptosis, anti-necroptosis, survival, protection, proliferation, and/or phenotypic modulation of a cell, as well as treating disease in a subject.
    Type: Application
    Filed: June 14, 2016
    Publication date: July 5, 2018
    Inventors: Robert A. Ashley, Lee Landeen
  • Publication number: 20070077232
    Abstract: Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder.
    Type: Application
    Filed: October 3, 2006
    Publication date: April 5, 2007
    Applicant: SkinMedica, Inc.
    Inventors: Gail Naughton, David Horwitz, Mark Applegate, Joan Zeltinger, Jonathan Mansbridge, Andreas Kern, Lee Landeen, Anthony Ratcliffe, R. Pinney
  • Publication number: 20060154365
    Abstract: The present disclosure provides compositions of three dimensional tissue that can be administered into tissues and organs using minimally invasive methods. The three dimensional tissues elaborate a repertoire of growth factors that facilitate repair or regeneration of damaged tissues and organs.
    Type: Application
    Filed: August 30, 2005
    Publication date: July 13, 2006
    Inventors: Anthony Ratcliffe, Jonathan Mansbridge, Lee Landeen, Emmett Pinney, Linette Edison
  • Patent number: 5478739
    Abstract: The present invention relates to an improved three-dimensional cell culture system in which cells are grown on a three-dimensional matrix while cycling the cultures between metabolically favorable and metabolically unfavorable (but noncytotoxic) conditions. The invention is based, at least in part, on the discovery that cycling the cultures in this manner optimizes the formation of extracellular matrix and produces an overall structure that more closely resembles naturally occurring tissue.
    Type: Grant
    Filed: October 23, 1992
    Date of Patent: December 26, 1995
    Assignee: Advanced Tissue Sciences, Inc.
    Inventors: Sandra R. Slivka, Lee Landeen