Abstract: Disclosed herein are systems, methods, and compositions useful for determining cellular pathway disruption comprising the use of RNA expression level information. This determined level of disruption can assist in the identification of genetic variants that alter pathway activity, to correlate these variants with disease state and disease progression, and to identify those therapeutics most likely to be effective and which should be avoided.

Abstract: A computing system for monitoring a terrestrial logistics network includes an event monitoring module, a logistics module, and a mapping module. The event monitoring module is configured to extract event classifications and event spatial locations from messages broadcast from a curated plurality of independent third party broadcasting entities. The logistics module is configured to assemble an augmented relational database representing a terrestrial logistics network that includes a plurality of interrelated nodes. The augmented relational database includes a spatial location for each interrelated node. The mapping module is configured to output a computer interface visually summarizing contents of both the augmented relational database and the spatial locations and classifications of events. In this way, events may be viewed in the context of the terrestrial logistics network, allowing for the deployment of proactive solutions to potential network disruptions.