Abstract: We disclose herein a flow sensor comprising: a first substrate comprising an etched portion, a dielectric region located on a first side of the first substrate, wherein the dielectric region comprises at least one dielectric membrane located over the etched portion of the first substrate, a sensing element located on or within the dielectric membrane, and a second substrate adjoining a second side of the first substrate. The first side of the first substrate and the second side of the first substrate are opposite sides. The first substrate and the second substrate cooperate to form a sensing channel through the flow sensor.

Abstract: A system, apparatus and method for a tightly sealed, low moisture vapor transmission, low relative humidity headspace atmosphere aseptic vaccine delivery with low particulate generation. The system can include a housing, desiccant and a biasing member designed to quickly and efficiently deliver medicament to a patient.

Abstract: A method of over-molding materials includes: providing a first material in a groove in a first portion of a mold such that only a single surface of the first material is exposed to a vacant portion of the mold; providing, via an injection molding process, a second material in a liquid form in the vacant portion of the mold adjacent to, and in engagement with, the first material; and allowing the second material to solidify and become directly coupled to the first material, thus forming a single component. During the method, the entire single surface of the first material is flush with a plane defined by outer surface of the first portion of the mold. The second material has one or both of a greater hardness when solidified than the first material and/or a higher melting temperature than the first material.

Abstract: A method of treating cancerous tumors is presented herein. The method includes injecting an effective dose of a plasmid encoded for IL-12, B7-1 or IL-15 into a cancerous tumor and subsequently administering at least one high voltage, short duration pulse to the tumor. The electroporation pulses may be administered at least 700V/cm for a duration of less than 1 millisecond. The intratumor treatments with electroporation may be administered in at least a two-treatment protocol with the time between treatments being about 7 days. The intratumor treatments with electroporation may be administered in a three-treatment protocol with a time of four days between the first and second treatments and a time of three days between the second and third treatments. It was found that the intratumor treatments using electroporation not only resulted in tumor regression but also induced an immune memory response which prevented the formation of new tumors.

Abstract: A moisture tight container includes a container body and a lid preferably linked to the body by a hinge. The body and lid include at least a first seal and a second seal in series to provide a moisture tight seal between the body and the lid. The first seal includes mating of thermoplastic-to-thermoplastic sealing surfaces of the body and lid respectively. The second seal includes mating of thermoplastic-to-elastomeric sealing surfaces of the body and lid, respectively, or of the lid and body, respectively.

Abstract: Disclosed are an entrained polymer or an entrained polymer composition, and a method for forming and adhering an entrained polymer structure to a substrate using the entrained polymer or an entrained polymer composition. The method includes providing a substrate configured to receive application of a molten entrained polymer. A particulate entrained polymer in molten form is applied in a predetermined shape, to a surface of the substrate, to form a solidified entrained polymer structure on the substrate. The entrained polymer includes a monolithic material formed of at least abase polymer and a particulate active agent. The surface of the substrate is compatible with the molten entrained polymer so as to thermally bond with it. In this way, the entrained polymer bonds to the substrate and solidifies upon sufficient cooling of the entrained polymer.

Abstract: Apparatuses and methods are provided for storing and preserving product, such as to extend shelf life of the same. In one optional method, liquid-exuding product is placed in a product containing space of a container atop a platform of a support structure. The container can include an internal compartment having the product containing space. The structure can define the platform for supporting the product. The internal compartment can further include a reservoir, configured to retain liquid, below the platform. At least one of the platform or the support structure can be configured to direct liquid exuded from the product to the reservoir. Optionally, the reservoir comprises or contains an absorbent material for absorbing liquid in the reservoir.

Abstract: Disclosed are an entrained polymer or an entrained polymer composition, and a method for forming and adhering an entrained polymer structure to a substrate using the entrained polymer or an entrained polymer composition. The method includes providing a substrate configured to receive application of a molten entrained polymer. A particulate entrained polymer in molten form is applied in a predetermined shape, to a surface of the substrate, to form a solidified entrained polymer structure on the substrate. The entrained polymer includes a monolithic material formed of at least a base polymer and a particulate active agent. The surface of the substrate is compatible with the molten entrained polymer so as to thermally bond with it. In this way, the entrained polymer bonds to the substrate and solidifies upon sufficient cooling of the entrained polymer.

Abstract: A moisture tight container includes a container body and a lid preferably linked to the body by a hinge. The body and lid include at least a first seal and a second seal in series to provide a moisture tight seal between the body and the lid. The first seal includes mating of thermoplastic-to-thermoplastic sealing surfaces of the body and lid respectively. The second seal includes mating of thermoplastic-to-elastomeric sealing surfaces of the body and lid, respectively, or of the lid and body, respectively.

Abstract: Disclosed are methods for forming and adhering an entrained polymer structure to a substrate. The methods include providing a substrate (114) configured to receive application of a molten entrained polymer (118). A mineral entrained polymer in molten form is applied in a predetermined shape, to a surface of the substrate, to form a solidified entrained polymer structure on the substrate. The entrained polymer includes a monolithic material formed of at least a base polymer (25) and a mineral active agent (30) to absorb excess moisture. The surface of the substrate is compatible with the molten entrained polymer so as to thermally bond with it. In this way, the entrained polymer bonds to the substrate and solidifies upon sufficient cooling of the entrained polymer. The polymer can have a channeling or foaming agent (35), eg polyglycol.

Abstract: Methods are provided for storing and preserving comestible crustacean material, preferably so as to extend shelf life of the same. In one optional method, comestible crustacean material is placed in a product containing space of a storage container atop a platform of a support structure. The storage container includes an internal compartment having the product containing space. The support structure defines the platform for supporting the comestible crustacean material. The internal compartment further includes a reservoir, configured to retain liquid, below the platform. The platform and/or support structure are configured to direct liquid exuded from the comestible crustacean material to the reservoir. Optionally, the reservoir comprises an absorbent material for absorbing liquid in the reservoir.

Abstract: Methods for storing and preserving cannabis or cannabis-containing substances using container assemblies are disclosed. An exemplary container assembly includes a lid and a container body. The lid is configured to be closed onto the container body over an opening of the container body. The opening provides access to an interior space having a product compartment configured to store product. The assembly also includes a humectant compartment permanently secured within the assembly. The humectant compartment includes a rigid housing containing a humectant solution. The rigid housing is configured within the assembly to prevent leaking of the humectant solution into the product compartment while facilitating bidirectional transmission of moisture between the humectant compartment and the product compartment. The humectant solution regulates relative humidity of the product compartment to maintain the relative humidity at a predetermined level.

Abstract: A method of over-molding materials includes: providing a first material in a groove in a first portion of a mold such that only a single surface of the first material is exposed to a vacant portion of the mold; providing, via an injection molding process, a second material in a liquid form in the vacant portion of the mold adjacent to, and in engagement with, the first material; and allowing the second material to solidify and become directly coupled to the first material, thus forming a single component. The second material has one or both of a greater hardness when solidified than the first material and/or a higher melting temperature than the first material.

Abstract: A method for storing and preserving moisture sensitive products includes providing a moisture tight container (400) having an insert (300) made from a desiccant entrained polymer that is less than 3.25 g in mass, disposing a plurality of moisture sensitive products into the interior compartment when the container is in the open position, and moving the container into the closed position, thereby creating a moisture tight seal between the lid (420) and the container body (401). The container provides a shelf life to the moisture sensitive products of at least 12 months. The container, when in the closed position, has a moisture vapor transmission rate, at ambient conditions of 30° C. and 75% relative humidity (RH), of less than 500|ig/day.

Abstract: A moisture tight container (100, 300) includes a container body (101, 301) and a lid (101, 120, 320) preferably linked to the body (101, 301) by a hinge (140, 340). The body (101, 301) and lid (101, 120, 320) include at least a first seal (462) and a second seal (464) in series to provide a moisture tight seal (460) between the body (101, 301) and the lid (101, 120, 320). The first seal (462) includes mating of thermoplastic-to-thermoplastic sealing surfaces of the body (101, 301) and lid (101, 120, 320) respectively. The second seal (464) includes mating of thermoplastic-to-elastomeric sealing surfaces of the body (101, 301) and lid (101, 120, 320), respectively, or of the lid (101, 120, 320) and body (101, 301), respectively.

Abstract: A child resistant container is for containing at least one product, such as medicine. The child resistant container includes a body, a lid, and a directing portion. The body has an end portion defining an opening leading to an interior of the body. The lid is connected to the body via a hinge, and includes a cover portion and a protrusion extending outwardly therefrom. The cover portion is configured to move between a FIRST position corresponding to the cover portion covering the opening, and a SECOND position corresponding to the cover portion not covering the opening. The directing portion extends from one of the body and the cover portion, and at least partially encloses the protrusion when the cover portion is in the FIRST position. When the cover portion moves from the FIRST position to the SECOND position, the protrusion moves away from the directing portion.

Abstract: A closed and tamper-evident sealed container, including a fluid transport adapter. The adapter provides for sterile fluid communication between a fluid source outside the container and the container interior when adapter is open. The adapter is adjustable to a closed position wherein the fluid communication ceases. An alternative to the adapter utilizes a sampling attachment that fits into tight engagement with the lid which comprises at least one septum. Coupling the sampling attachment to the lid either causes sharps in the attachment to penetrate the at least one septum or to displace the edges of the septum inward to form a fluid communication with the container interior while the lid remains sealed closed. Other variations include a rotatable sampling attachment, a container with a displaceable bottom wall to act as a syringe and a large volume (e.g., 1500 mL) sealed ampoule which also uses a sampling attachment.