Abstract: An anti-loose screw suitable for fastening various construction work pieces comprises: a screw head; a cylindrical rod, coupled to the screw head; a high thread and a low thread, spiraling around the cylindrical rod, and uniformly distributed on the cylindrical rod, wherein the crests of the low thread on the cylindrical rod are machined by a cutter to form cut slots and irregular burrs. When the screw is driven into a construction work piece, those two uniformly distributed high and low threads can keep the balance of the advancing screw so that the advancing screw can be free from any deviation. Further, the extruded scraps will be concentrated to provide a superior anchoring effect. Furthermore, in cooperation with the wrapping effect of the expanding material of the work piece, the cut slots and burrs formed via the machining of a cutter can raise the anti-loose capability of the screw.