Abstract: The present invention regards angiopoietin-1, which is a stabilizing factor for endothelial cells. The invention relates to angiopoietin-1 specifically as an inhibitor of tumor growth and angiogenesis, particularly for the treatment of cancer. In a particular embodiment, angiopoietin-1 is utilized to induce tumor dormancy or limit tumor growth by stabilizing the endothelium and preventing endothelial cell proliferation, and, thus, preventing angiogenesis.

Abstract: Conjugate molecules comprising a ligand bonded to a polymer are disclosed. One such conjugate molecule comprises a ligand bonded to a polymer, a chelating agent bonded to the polymer, and a radioisotope chelated to the chelating agent. The conjugate molecules may be useful in detecting and/or treating tumors or biological receptors. These conjugate molecules may be synthesized without the necessity of preactivation of the ligand using an SCN-polymer-chelating agent precursor. Conjugate molecules incorporating an annexin V ligand are particularly useful for visualizing apoptotic cells. Conjugate molecules incorporating a C225 ligand are particularly useful for targeting tumors expressing EGFR.