Abstract: Disclosed are anti-angiogenic agents that target Pfn1:actin interaction. Also disclosed are compounds for treating ocular diseases or conditions. Further disclosed are compounds for treating cancer.

Abstract: A clamp for a flexible pipe is provided that provide a load bearing flange on the flexible pipe permitting buoyancy jackets to be joined thereto. The clamp has a longitudinal axis arranged to extend along the length of the flexible pipe and a radial axis being perpendicular to the longitudinal axis. The clamp includes: a plurality of separate clamp elements being supported together in a radial array extending at least partially around the longitudinal axis; engagement means located between neighboring clamp elements to movably interconnect the clamp elements; and a strap being adapted to surround the clamp elements, in use for exerting a compressive force thereon. Also provided is a clamp element for use in the aforementioned clamp.

Abstract: A clamp for a flexible pipe is provided that provide a load bearing flange on the flexible pipe permitting buoyancy jackets to be joined thereto. The clamp has a longitudinal axis arranged to extend along the length of the flexible pipe and a radial axis being perpendicular to the longitudinal axis. The clamp includes: a plurality of separate clamp elements being supported together in a radial array extending at least partially around the longitudinal axis; engagement means located between neighboring clamp elements to movably interconnect the clamp elements; and a strap being adapted to surround the clamp elements, in use for exerting a compressive force thereon. Also provided is a clamp element for use in the aforementioned clamp.

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

Abstract: The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.

Abstract: The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.

Abstract: Disclosed are novel 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid amides, and their pharmaceutically acceptable salts and esters, that are selective inhibitors of KDR and/or FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular solid cancerous tumors of the breast, colon, lung and prostate. Also disclosed are pharmaceutical compositions containing these compounds and methods of treating cancer using these compounds.