Abstract: Methods and systems of patient treatment are disclosed. The methods and systems include use of medical device informatics to modify and validate therapies and drugs used in those therapies. In certain embodiments, a medical device, such as a medical infusion pump, interfaces with a server to administer the patient treatments. In one aspect, a method of retrieving medical event log results is disclosed. The method includes receiving at a server event log data generated by a medical device, and storing the event log data in a memory of the server. The method further includes receiving a request for a subset of the event log data, the subset of the event log data defined by at least one characteristic. The method also includes filtering the event log data based on the characteristic.

Abstract: Methods and systems of patient treatment are disclosed. The methods and systems include use of medical device informatics to modify and validate therapies and drugs used in those therapies. In certain embodiments, a medical device, such as a medical infusion pump, interfaces with a server to administer the patient treatments. In one aspect, a medical device server is disclosed. The medical device server includes a memory configured to store patient status information and command information and a programmable circuit operatively connected to the memory. The programmable circuit is configured to execute program instructions to receive patient status information from a first medical device, the patient status information related to a patient and determine the need for treatment of the patient. The programmable circuit is also configured to execute program instructions to transmit a command to a second medical device configured to provide the treatment.

Abstract: Methods and systems of patient treatment are disclosed. The methods and systems include use of medical device informatics to modify and validate therapies and drugs used in those therapies. In certain embodiments, a medical device, such as a medical infusion pump, interfaces with a server to administer the patient treatments. In one aspect, a medical device network is disclosed which includes a plurality of medical devices dispersed across two or more time zones, and a server operatively connected to the medical devices. The server includes a memory configured to hold event log data and a programmable circuit operatively connected to the memory. The programmable circuit is configured to execute program instructions to receive event log data from the plurality of medical devices, and to modify the time zone information in the event log data. The programmable circuit is also configured to execute program instructions to store the event log data in the memory.

Abstract: Methods and systems of patient treatment are disclosed. The methods and systems include use of medical device informatics to modify and validate therapies and drugs used in those therapies. In certain embodiments, a medical device, such as a medical infusion pump, interfaces with a server to administer the patient treatments. In one aspect, a method of scheduling maintenance of a medical device is disclosed. The method includes storing a medical device maintenance schedule on a computing system remote from the medical device, the medical device maintenance schedule including a reminder to perform maintenance on the medical device. The method further includes transmitting the reminder from the computing system to the medical device.

Abstract: The present invention concerns methods and compositions for making and using Be complexes of defined compositions, which may have multiple functionalities and/or binding specificities. In various embodiment, Beryllium (Be) complexes may include Be such as 10Be and 7Be complexes. Such complexes find use in a wide variety of applications, particularly in the field of treatment, detection and/or diagnosis of infections, diseases and other health-related conditions, including but not limited to cancer, autoimmune disease, cardiovascular disease, metabolic diseases, degenerative diseases, and organ transplant rejection.

Abstract: The present invention provides for methods for detection, diagnosis and prognosis of beryllium-induced disease. In one embodiment, the methods include exposing immune cells from subjects suspected of having beryllium-induced disease to beryllium and assessing the Th-1 cytokines produced. Other embodiments include the use of exposing immune cells from subjects suspected of having beryllium-induced disease to beryllium and assessing Th-1 cytokines produced and using these assessments to indicate the stage of progression of the disease. Therapeutic methods involve assessing the onset or progression of beryllium-induced disease before during and after exposure to a treatment for the disease.

Abstract: Methods for therapy of cystic fibrosis and other conditions are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e. ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis and/or another condition responsive to stimulation of thiol-containing compound transport.

Abstract: A current-mode D/A converter is described having variable output and offset control. According to an exemplary embodiment, a first D/A converter includes a number of first control inputs and an output capable of generating a first current proportional to a number of active first control inputs. A driver includes an input connected to the output of the first D/A converter, a number of second control inputs, and an output capable of generating a second current proportional to the first current based on a number of active second control inputs. A second D/A converter includes a number of third control inputs and an output capable of generating a third current proportional to a number of active third control inputs. Offset control circuitry includes an input connected to the output of the second D/A converter, an offset control input, and an output connected to the output of the driver.

Abstract: A current-mode D/A converter is described having variable output and offset control. According to an exemplary embodiment, a first D/A converter includes a number of first control inputs and an output capable of generating a first current proportional to a number of active first control inputs. A driver includes an input connected to the output of the first D/A converter, a number of second control inputs, and an output capable of generating a second current proportional to the first current based on a number of active second control inputs. A second D/A converter includes a number of third control inputs and an output capable of generating a third current proportional to a number of active third control inputs. Offset control circuitry includes an input connected to the output of the second D/A converter, an offset control input, and an output connected to the output of the driver.

Abstract: A method and circuit for controlling the contrast of a liquid crystal display (LCD). The circuit includes a switching regulator circuit which generates a negative voltage at the output thereof, with the switching regulator circuit having a feedback node therein and also having a voltage regulator with a control input therein. An injected current coupled to the feedback node and the control input to the voltage regulator is used to provide a changed negative voltage at the output of the regulator circuit. Control values stored in the memory of a controller are used to select the injected current. The changed negative voltage at the output of the regulator circuit is used to control the contrast of the LCD.

Abstract: A method and circuit for quickly starting a negative switching voltage regulator to reach a certain level of negative voltage. A regulator chip is used in the circuit, with the circuit having an output terminal from which the negative voltage is obtained. The chip has a start pin thereon and also has an internal transistor which switches on and off to provide an increasing negative voltage at the output terminal. In response to a Start signal at the start pin, a start up circuit is used to provide a forcing current at the output terminal via a second source of negative voltage. When the increasing negative voltage at the output terminal reaches the voltage level of the second source, the start up circuit is turned off.