Abstract: The present invention includes compounds and compositions, and methods of use thereof for modulating an RNA transcript, or a precursor, isoform, fragment, or mutant thereof by degradation of the RNA transcript via recruitment or binding of one or more decay factors (e.g., an RNA binding protein).

Abstract: A video game includes a plurality of components providing for opportunities for increased social interaction of users playing the video game. The video game may be a music-based video game, and a server may provide content of the video game to game devices for play at predefined times.

Abstract: Disclosed are compositions and methods for treatment of breast cancer. Disclosed methods and compositions include dendritic cells loaded with cyclin B1 and WT-1 peptide antigens for immunotherapy. These dendritic cell vaccines are administered alone or in combination with other cancer therapies to improve outcomes. Disclosed methods also involve the use of therapeutic agents, such as anakinra, that block the IL-1 inflammation pathway. These agents are used in combination with chemotherapy and/or immunotherapy in treating breast cancer.

Abstract: A video game includes user generated content. The video game may be a music-based video game. Users may determine content to be played, and a server may provide the content to game devices for play, for example at predefined times, and/or to predetermined game players.

Abstract: A video game includes a plurality of components providing for opportunities for increased social interaction of users playing the video game. The video game may be a music-based video game, and a server may provide content of the video game to game devices for play at predefined times.

Abstract: A video game includes user generated content. The video game may be a music-based video game. Users may determine content to be played, and a server may provide the content to game devices for play, for example at predefined times, and/or to predetermined game players.

Abstract: Disclosed are compositions and methods for treatment of breast cancer. Disclosed methods and compositions include dendritic cells loaded with cyclin B1 and WT-1 peptide antigens for immunotherapy. These dendritic cell vaccines are administered alone or in combination with other cancer therapies to improve outcomes. Disclosed methods also involve the use of therapeutic agents, such as anakinra, that block the IL-1 inflammation pathway. These agents are used in combination with chemotherapy and/or immunotherapy in treating breast cancer.

Abstract: Disclosed is a physical therapy support, comprising a planar structure having a first and second end and an upper and lower surface that reduces friction between the lower body of a patient and a hospital bed. The device is positioned between a patient's hips and the underlying bed sheets, whereby the patient is elevated and separated from the sheets to allow freedom of movement and increased support when engaging in hip and lower body movements for recovery and physical therapy sessions. The shape of the device includes a first rounded end and a second flat end to form a triangular shape having tapering longitudinal sides. The cross section comprises a thin, rigid and uniform material having a low friction upper surface and a high friction lower surface. A slot penetration along the one of the tapering sides allows for handling of the device and for transporting between patients.

Abstract: A method of responding to a request for web page includes the steps of receiving a request, extracting search query parameters from a request and redirecting to a mapped web page or alternatively responding with the requested web page. The search query parameters and requested web page are associated with each and stored for later processing and assignment.

Abstract: A system, method, and computer readable medium for affiliate redirection. There are process steps and modules for receiving a first URL request, recording request information regarding the first URL request; making the request information available to a merchant; and redirecting the URL request to a second URL having no variables, wherein the redirection indicates a permanent redirection. Additional steps include: instructing a shopper to write a cookie containing request information, sending request information directly to a merchant before the step of redirecting the URL request to a second URL having no variables, receiving a second URL request and providing content modified according to request information, providing content modified according to request information includes displaying an affiliate logo, providing an expiring cookie, and linking an affiliate ID to customization information and wherein the content is modified to display the customization information.

Abstract: There is a method of referral marketing over a computerized network configured to incentivize participation and thereby enhance the effectiveness thereof; wherein the method includes steps of providing a webpage to sell products/services over a computerized network. The method includes providing a hypertext offering to a shopper, for a referred shopper to view the products/services purchased by the shopper. Then, creating a discount coupon including a discount code for the referred shopper using a merchant module having a hypertext link to the webpage. The method also includes sending an email including the discount coupon to the referred shopper over the computerized network. Then, the method includes creating an incentive coupon including an incentive code for the shopper that referred the referred shopper. In addition, the method may include sending an email including the incentive coupon to the shopper that referred the referred shopper over the computerized network.

Abstract: Methods of eliciting an immune response in a subject by administering one or more large genomic DNA fragments are provided. Also provided are methods of identifying sequences encoding antigenic polypeptides. Also provided are vaccine compositions comprising one or more large genomic DNA fragments.

Abstract: This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active compounds as desribed herein, particularly anti-parasitic agents.

Abstract: The invention described herein relates to: the use of an effective inhibitor of a bacterial ?-amylase and/or ?-glucosidase in the manufacture of a composition for the treatment of rumen acidosis; a method of treatment of rumen acidosis which comprises administration of an effective amount of an effective inhibitor of a bacterial ?-amylase and/or ?-glucosidase to a ruminant; a formulation suitable for the treatment of rumen acidosis in an animal which comprises an effective inhibitor of a bacterial ?-amylase and/or ?-glucosidase in admixture with a suitable excipient, diluent or carrier selected with regard to the intended route of administration and standard pharmaceutical/veterinary/farming practice; screening methods useful in the identification of a suitable inhibitor of a bacterial ?-amylase and/or ?-glucosidase for the treatment of acidosis in a ruminant; a process for improving ruminant milk quality and/or quantity which comprises treatment of a ruminant with an effective amount of an inhibitor of bact

Abstract: Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: X represents —[CH2]a—R or —[CH2]a—O—[CH2]b—R; a represents a number selected from 0 to 6; b represents a number selected from 0 to 6; R represents H, CF3 or Het; Het represents an optionally substituted 5- or 6-membered saturated, partially saturated or aromatic heterocyclic ring; Y represents one or more substituents independently selected from —[O]c—[CH2]d—R1, which may be the same or different at each occurrence; c at each occurrence independently represents a number selected from 0 or 1; d at each occurrence independently represents a number selected from 0 to 6; R1 at each occurrence independently represents H, halo, CF3, CN or Het1; Het1 at each occurrence independently represents a 5- or 6-membered unsaturated heterocyclic ring; V represents a direct link or —O—; Ring A represents an optionally substituted 5- to 7-membered saturated heterocyclic ring, or a phenylene group; Q represents a direct link or

Abstract: This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

Abstract: There is provided a compound of formula I, wherein Het1, T, X, R1, R2 and R3 have meanings given in the description, which are useful in the prophylaxis and in the treatment of diseases mediated by opiate receptors, such as pruritus.