Abstract: The present invention relates to Shiga toxin effector polypeptides with reduced antigenic and/or immunogenic potential. Immunogenicity can be a limitation for the repeated administration to mammals of proteins and polypeptides derived from Shiga toxins. The Shiga toxin effector polypeptides of the present invention have uses as components of therapeutics, diagnostics, and immunization materials. The cytotoxic proteins of the present invention have uses for selective killing of specific cell types and as therapeutics for the treatment of a variety of diseases, including cancers, immune disorders, and microbial infections. The proteins of the present invention also have uses for detecting specific cell types, collecting diagnostic information, and monitoring the treatment of a variety of diseases, such as, e.g., cancers, immune disorders, and microbial infections.

Abstract: The present invention relates to Shiga toxin effector polypeptides with reduced antigenic and/or immunogenic potential. Immunogenicity can be a limitation for the repeated administration to mammals of proteins and polypeptides derived from Shiga toxins. The Shiga toxin effector polypeptides of the present invention have uses as components of therapeutics, diagnostics, and immunization materials. The cytotoxic proteins of the present invention have uses for selective killing of specific cell types and as therapeutics for the treatment of a variety of diseases, including cancers, immune disorders, and microbial infections. The proteins of the present invention also have uses for detecting specific cell types, collecting diagnostic information, and monitoring the treatment of a variety of diseases, such as, e.g., cancers, immune disorders, and microbial infections.

Abstract: An ultrasonic transducer probe comprises an array transducer and a microbeamformer ASIC (46a, 46b) containing transmit amplifiers and receive circuitry for operation of the array transducer. For higher power operation, the drive current of the amplifiers is increased, rather than the transmit voltage. The elements of the array present a low impedance to the transmit amplifiers for increased drive current by their construction of thin layers (12) of piezoelectric material which are electrically coupled in parallel to an amplifier while being mechanically coupled in series for ultrasound transmission.

Abstract: A ballast dispenser system and method for flight vehicles, such as high altitude lighter than air vehicles. The system passively retains ballast without power and deploys ballast in response to applying power. An electro-permanent magnet passively retains ballast within the dispenser. Application of power to a coil produces an opposing magnetic field that reduces the overall strength of a net magnetic field acting on the ballast. Lateral positional control of the electro-permanent magnet provides calibration and control of the retaining magnetic field strength. A collapsible silo may hold ballast prior to dispensing ballast and collapse upon landing for minimizing damage.

Abstract: The invention is directed to an ultrasound probe (1) configured to be operatively coupled to a cable (10), the cable (10) comprising a plurality of lanes adapted to carry signals between the ultrasound probe (1) and a data processing unit, which is adapted to process the signals, in particular to beamform the signals and to reconstruct ultrasound images of an imaging region. The ultrasonic probe (1) comprises a transducer head comprising a plurality of transducer elements, which are adapted to insonify the imaging region according to an insonification scheme and to receive ultrasound signals, and a controller adapted to, responsive to the information of a faulty lane from a fault detection module adapted to detect integrity of each of the plurality of lanes, redistribute and/or reconfigure the signals carried by the faulty lane onto one or more of the non-faulty lanes.

Abstract: Ultrasound imaging systems are provided. An ultrasound system according to some embodiments includes a console configured to selectively communicate with a first ultrasound imaging device and a second ultrasound imaging device. The console includes a housing, a computing device disposed within the housing, and a connector receptacle assembly coupled to the housing. The connector receptacle assembly includes a first connector bank including a first plurality of electrical connections; and a second connector bank including a second plurality of electrical connections. The connector receptacle assembly is selectively matable to a first connector of the first ultrasound imaging device via only the first connector bank and to a second connector of the second ultrasound imaging device via the first and second connector banks.

Abstract: The present invention provides cell-targeting molecules which can deliver a CD8+ T-cell epitope cargo to the MHC class I presentation pathway of a target cell. The cell-targeting molecules of the invention can be used to deliver virtually any CD8+ T-cell epitope from an extracellular space to the MHC class I pathway of a target cell, which may be a malignant cell and/or non-immune cell. The target cell can then display on a cell-surface the delivered CD8+ T-cell epitope complexed with MHC I molecule. The cell-targeting molecules of the invention have uses which include the targeted labeling and/or killing of specific cell-types within a mixture of cell-types, including within a chordate, as well as the stimulation of beneficial immune responses. The cell-targeting molecules of the invention have uses, e.g., in the treatment of a variety of diseases, disorders, and conditions, including cancers, tumors, growth abnormalities, immune disorders, and microbial infections.

Abstract: Intraluminal imaging devices that include multiple conductor segments having conductors (312, 316) of different sizes at particular locations along the length of the intraluminal imaging device are provided. For example, the intraluminal imaging device may include a cable (310) comprising a proximal portion and a distal portion, an electrical connector (314) coupled to the proximal portion of the cable, and a flexible elongate member (320) comprising a proximal portion and a distal portion. A first plurality of conductors extends within the cable and a second plurality of conductors extends within the flexible elongate member. Each conductor of the first plurality of conductors is electrically coupled to a respective conductor of the second plurality of conductors. A conductor of the first plurality of conductors having a first cross section is electrically coupled to a conductor of the second plurality of conductors having a second cross section that is smaller than the first cross section.

Abstract: A self-locking latch assembly for a two-piece container is provided. The latch assembly has a latch hook pivotably biased in a parallel orientation to the first piece of the two-piece container, while a keeper is connected though spaced apart from the surface of the second piece of the two-piece container. The two-piece container is adapted to move between an open and closed position by sliding an open end of the larger piece over an open end of a smaller piece. During this sliding action, toward the closed position, a tapered edge of the latch hook strikes the keeper and is urged upward until the tapered edge ends, whereby the biasing of the latch hook urges it to engage the keeper in a locked condition. To unlock the latch hook, one can pivot it to a nonparallel orientation and slide the two pieces apart.

Abstract: The present invention relates to Shiga toxin A Subunit derived polypeptides and cell-targeting molecules comprising amino acid substitutions which equip the polypeptides with 1) de-immunization; 2) reduced, protease-cleavage sensitivity; and/or 3) a heterologous epitope cargo(s) while retaining Shiga toxin function(s), such as, e.g., potent cytotoxicity. Certain polypeptides of the invention exhibit reduced immunogenic potential in mammals and/or are capable of delivering an epitope to an MHC class molecule of a cell in which the polypeptide is present. Certain molecules comprising a polypeptide of the invention are well-tolerated by mammals while retaining one or more of the features mentioned above.

Abstract: The present invention relates to Shiga toxin effector polypeptides with reduced antigenic and/or immunogenic potential. Immunogenicity can be a limitation for the repeated administration to mammals of proteins and polypeptides derived from Shiga toxins. The Shiga toxin effector polypeptides of the present invention have uses as components of therapeutics, diagnostics, and immunization materials. The cytotoxic proteins of the present invention have uses for selective killing of specific cell types and as therapeutics for the treatment of a variety of diseases, including cancers, immune disorders, and microbial infections. The proteins of the present invention also have uses for detecting specific cell types, collecting diagnostic information, and monitoring the treatment of a variety of diseases, such as, e.g., cancers, immune disorders, and microbial infections.

Abstract: The present invention provides cell-targeting molecules which can deliver a CD8+ T-cell epitope cargo to the MHC class I presentation pathway of a target cell. The cell-targeting molecules of the invention can be used to deliver virtually any CD8+ T-cell epitope from an extracellular space to the MHC class I pathway of a target cell, which may be a malignant cell and/or non-immune cell. The target cell can then display on a cell-surface the delivered CD8+ T-cell epitope complexed with MHC I molecule. The cell-targeting molecules of the invention have uses which include the targeted labeling and/or killing of specific cell-types within a mixture of cell-types, including within a chordate, as well as the stimulation of beneficial immune responses. The cell-targeting molecules of the invention have uses, e.g., in the treatment of a variety of diseases, disorders, and conditions, including cancers, tumors, growth abnormalities, immune disorders, and microbial infections.

Abstract: The present invention relates to Shiga toxin A Subunit derived polypeptides and cell-targeting molecules comprising amino acid substitutions which equip the polypeptides with 1) de-immunization; 2) reduced, protease-cleavage sensitivity; and/or 3) a heterologous epitope cargo(s) while retaining Shiga toxin function(s), such as, e.g., potent cytotoxicity. Certain polypeptides of the invention exhibit reduced immunogenic potential in mammals and/or are capable of delivering an epitope to an MHC class molecule of a cell in which the polypeptide is present. Certain molecules comprising a polypeptide of the invention are well-tolerated by mammals while retaining one or more of the features mentioned above.

Abstract: A system for generating mist includes a vehicle with ventilation system, a misting device configured to atomized fluid to generate a variable amount of mist, and a fan configured to move the variable amount of mist through the ventilation system. The system further includes a particle sensor configured to measure particles and a controller in communication with the particle sensor, misting device, and fan, configured to receive a particle concentration from the particle sensor, compare it to a threshold, and control the variable amount of mist and/or the fan to keep the particle concentration greater than the threshold. A method for controlling mist in a vehicle includes pumping fluid to a misting device, generating a mist of fluid, pumping the mist into a vehicle ventilation system, measuring a particle concentration, and manipulating a misting device, pump, and/or fan using a controller to keep the particle concentration above a threshold.

Abstract: A new and distinct variety of Cercis plant named ‘RNI-RCC3’ is disclosed, characterized by distinctive, dark purple foliage that retains its color in heat. Plants are very straight and upright, with exceptional vigor. The new variety is a Cercis, normally used for outdoor ornamental purposes.

Abstract: A new and distinct variety of apple tree rootstock Malus domestica x Malus robusta hybrid ‘G.257’ is described. The new variety is a semi-dwarfing rootstock that is resistant to fire blight (Erwinia amylovora) and crown rot (Phytophthora cactorum) and tolerant to the replant disease complex. The ‘G.257’ rootstock is useful in that it can be propagated clonally and used as a rootstock or root system for apple trees as well as for interstems of apple trees.

Abstract: A new and distinct variety of apple tree rootstock Malus hybrid ‘G.484’ is described herein. The new variety is a dwarfing, precocious and productive rootstock that is resistant to fire blight (Erwinia amylovora) and crown rot (Phytophthora cactorum). The ‘G.484’ rootstock is useful in that it can be propagated clonally and used as a rootstock or root system for apple trees as well as for interstems of apple trees.

Abstract: A new and distinct variety of apple tree rootstock Malus domestica x Malus robusta hybrid ‘G.66’ is described herein. The new variety is a productive, yield efficient, semi-dwarfing rootstock that is resistant to fire blight (Erwinia amylovora) and crown rot (Phytophthora cactorum). The ‘G.66’ rootstock is useful in that it can be propagated clonally and used as a rootstock or root system for apple trees as well as for interstems of apple trees.

Abstract: A new and distinct cultivar of Styrax plant named ‘RNI-RIXRED’ is disclosed, characterized by dark, glossy foliage with emerging new growth colored bronze. Flowers bloom twice per year, in spring and again in fall. Petite, white flowers have a shiny quality. The new variety is a Styrax, normally used for outdoor ornamental purposes.