Patents by Inventor Lee S. Chong

Lee S. Chong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD AND COMPOSITIONS FOR TREATING HEMATOLOGICAL MALIGNANCIES
    Publication number: 20110172192
    Abstract: A compound of formula 1 and/or its salts, tautomers or solvates is used to treat hematological malignancies. In an embodiment, an organic acid salt of compound 1 is provided for general use in treatment of neoplasms, and in a further embodiment the salt is stabilized with carbohydrate.
    Type: Application
    Filed: March 23, 2011
    Publication date: July 14, 2011
    Applicant: Gilead Sciences, Inc.
    Inventors: Adrian S. Ray, Daniel B. Tumas, Hans Reiser, William J. Watkins, William A. Lee, Lee S. Chong
  • 2,4,6-TRISUBSTITUTED PYRIDO(3,2-d) PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS
    Publication number: 20110123493
    Abstract: Pyrido(3,2-d)pyrimidine derivatives represented by the structural formula (Ia): wherein, R1, R2 and R3 are defined herein, pharmaceutical acceptable addition salts, stereochemical isomeric forms, N-oxides, solvates and pro-drugs thereof, for use in the treatment of hepatitis C.
    Type: Application
    Filed: July 1, 2009
    Publication date: May 26, 2011
    Applicant: Gilead Sciences, Inc.
    Inventors: Eda Canales, Lee S. Chong, Michael O' Neil Hanrahan Clarke, Scott E. Lazerwith, Willard Lew, Qi Liu, Michael L. Mitchell, William J. Watkins, Jennifer R. Zhang
  • Nucleoside Phosphonate Analogs
    Publication number: 20110071101
    Abstract: The invention is related to phosphorus substituted nucleoside compounds and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 9, 2008
    Publication date: March 24, 2011
    Inventors: Constantine G. Boojamra, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Alan X. Huang, Choung U. Kim, Thorsten Kirschberg, Christopher P. Lee, David A. Oare, Vidya K. Prasad, Adrian S. Ray, Sundaramoorthi Swaminathan, William J. Watkins
  • INHIBITORS OF FLAVIVIRIDAE VIRUSES
    Publication number: 20110020278
    Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
    Type: Application
    Filed: July 19, 2010
    Publication date: January 27, 2011
    Applicant: Gilead Sciences, Inc.
    Inventors: Eda Canales, Lee S. Chong, Michael O'Neil Hanrahan Clarke, Edward Doerffler, Scott E. Lazerwith, Willard Lew, Qi Liu, Michael Mertzman, Philip A. Morganelli, William J. Watkins, Hong Ye
  • PYRIDO(3,2-d)PYRIDMIDINES USEFUL FOR TREATING VIRAL INFECTIONS
    Publication number: 20100048559
    Abstract: This invention provides pyrido(3,2-d)pyrimidine derivatives represented by the structural formula (I), wherein: R1 is amino, R4 is hydrogen, and R2 and R3 together provide a specific substitution pattern, pharmaceutical acceptable addition salts, stereochemical isomeric forms, N-oxides, solvates and pro-drugs thereof, are useful in the treatment of hepatitis C.
    Type: Application
    Filed: December 24, 2007
    Publication date: February 25, 2010
    Applicant: Gilead Science, Inc
    Inventors: Steven S. Bondy, William J. Watkins, Lee S. Chong, Piet Andre Maurits Maria Herdewijn, Steven Cesar Alfons De Jonghe
  • ANTI-CANCER PHOSPHONATE ANALOGS
    Publication number: 20100022467
    Abstract: The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: September 2, 2008
    Publication date: January 28, 2010
    Inventors: Constantine G. Boojamra, Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Alan X. Huang, Choung U. Kim, Thorsten Kirschberg, Steven Krawczyk, Christopher P. Lee, Kuei-Ying Lin, Richard L. Mackman, David Y. Markevitch, Peter H. Nelson, David A. Oare, Vidya K. Prasad, Hyung-Jung Pyun, Adrian S. Ray, Sundaramoorthi Swaminathan, William J. Watkins, Jennifer R. Zhang, Lijun Zhang
  • Therapeutic phosphonate compounds
    Patent number: 7645747
    Abstract: The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: January 12, 2010
    Assignee: Gilead Sciences, Inc.
    Inventors: Constantine G. Boojamra, Carina E. Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Manoj Desai, Maria Fardis, Craig S. Gibbs, Ralph F. Hirschmann, Alan X. Huang, Haolun Jin, Choung U. Kim, Thorsten A. Kirschberg, Steven Krawczyk, Christopher P. Lee, William A. Lee, Kuei-Ying Lin, Richard L. Mackman, David Y. Markevitch, Peter H. Nelson, David A. Oare, Vidya K. Prasad, Hyung-Jung Pyun, Adrian S. Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William J. Watkins, Jennifer R. Zhang, Lijun Zhang
  • SUBSTITUTED PTERIDINES FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTIONS
    Publication number: 20090318456
    Abstract: Tri-substituted pteridines and tetra-substituted pteridines exhibit a significant and selective activity against certain types of viral infections, in particular they selectively inhibit the replication of the hepatitis C virus, and are useful for the prevention and treatment of such infections.
    Type: Application
    Filed: July 6, 2007
    Publication date: December 24, 2009
    Applicant: Gilead Sciences, Inc.
    Inventors: Piet André Maurits Maria Herdewijn, Steven Cesar Alfons De Jonghe, William A. Lee, William John Watkins, Steven S. Bondy, Lee S. Chong
  • ANTIVIRAL PHOSPHONATE ANALOGS
    Publication number: 20090275535
    Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: July 1, 2008
    Publication date: November 5, 2009
    Inventors: Constantine G. Boojamra, Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Haolun Jin, Ralph F. Hirschmann, Alan X. Huang, Choung U. Kim, Thorsten Kirschberg, Christopher P. Lee, William A. Lee, Richard L. Mackman, David Y. Markevitch, David A. Oare, Vidya K. Prasad, Hyung-Jung Pyun, Adrian S. Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William J. Watkins, Jennifer R. Zhang
  • METHOD AND COMPOSITIONS FOR TREATING HEMATOLOGICAL MALIGNANCIES
    Publication number: 20090258840
    Abstract: A compound of formula (1), and/or its salts, tautomers or solvates is used to treat hematological malignancies. In an embodiment, an organic acid salt of compound 1 is provided for general use in treatment of neoplasms, and in a further embodiment the salt is stabilized with carbohydrate.
    Type: Application
    Filed: May 16, 2007
    Publication date: October 15, 2009
    Applicant: Gilead Sciences, Inc.
    Inventors: Lee S. Chong, William S. Lee, Adrian S. Ray, Hans Reiser, Daniel B. Tumas, William J. Watkins
  • PHOSPHONATE COMPOUNDS HAVING IMMUNO-MODULATORY ACTIVITY
    Publication number: 20090227543
    Abstract: The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: July 1, 2008
    Publication date: September 10, 2009
    Inventors: Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Manoj Desai, Maria Fardis, Alan X. Huang, Thorsten Kirschberg, Christopher P. Lee, Richard L. Mackman, Peter H. Nelson, Hyung-Jung Pyun, Adrian S. Ray, William J. Watkins, Jennifer R. Zhang, Sundaramoorthi Swaminathan
  • MODULATORS OF TOLL-LIKE RECEPTOR 7
    Publication number: 20090202484
    Abstract: The present application provides for a compound of Formula (I) or (II): or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods that include the administration of such compounds with at least one additional active agent.
    Type: Application
    Filed: July 6, 2007
    Publication date: August 13, 2009
    Applicant: Gilead Sciences, Inc.
    Inventors: Lee S. Chong, Manoj C. Desai, Brian Gallagher, Michael Graupe, Randall L. Halcomb, Hong Yang, Jennifer R. Zhang
  • KINASE INHIBITORY PHOSPHONATE ANALOGS
    Publication number: 20090181930
    Abstract: The invention is related to phosphorus substituted kinase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: July 2, 2008
    Publication date: July 16, 2009
    Inventors: Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Manoj Desai, Maria Fardis, Thorsten Kirschberg, Richard L. Mackman, Sundaramoorthi Swaminathan, William J. Watkins
  • PHOSPHONATE ANALOGS FOR TREATING METABOLIC DISEASES
    Publication number: 20090131372
    Abstract: The invention is related to phosphorus substituted compounds with activity for treating metabolic diseases and/or disorders, e.g., diabetes and hypercholesterolemia, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: June 24, 2008
    Publication date: May 21, 2009
    Inventors: James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Thorsten Kirschberg, Steven Krawczyk, Hyung-Jung Pyun, William J. Watkins
  • Phosphonate compounds having immuno-modulatory activity
    Patent number: 7470724
    Abstract: The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: December 30, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Manoj Desai, Maria Fardis, Alan X. Huang, Thorsten Kirschberg, Christopher P. Lee, Richard L. Mackman, Peter H. Nelson, Hyung-Jung Pyun, Adrian S. Ray, William J. Watkins, Jennifer R. Zhang, Sundaramoorthi Swaminathan
  • Anti-cancer phosphonate analogs
    Patent number: 7452901
    Abstract: The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: November 18, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Constantine G. Boojamra, Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Alan X. Huang, Choung U. Kim, Thorsten Kirschberg, Steven Krawczyk, Christopher P. Lee, Kuei-Ying Lin, Richard L. Mackman, David Y. Markevitch, Peter H. Nelson, David A. Oare, Vidya K. Prasad, Hyung-Jung Pyun, Adrian S. Ray, Sundaramoorthi Swaminathan, William J. Watkins, Jennifer R. Zhang, Lijun Zhang
  • Antiviral phosphonate analogs
    Patent number: 7429565
    Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: September 30, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Constantine G. Boojamra, Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Haolun Jin, Ralph F. Hirschmann, Alan X. Huang, Choung U. Kim, Thorsten Kirschberg, Christopher P. Lee, William A. Lee, Richard L. Mackman, David Y. Markevitch, David A. Oare, Vidya K. Prasad, Hyung-Jung Pyun, Adrian S. Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William J. Watkins, Jennifer R. Zhang
  • Purine nucleoside phosphorylase inhibitory phosphonate compounds
    Patent number: 7427624
    Abstract: The invention is related to phosphorus substituted purine nucleoside phosphorylase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: September 23, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Thorsten Kirschberg, Adrian S. Ray, Sundaramoorthi Swaminathan, William J. Watkins
  • Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
    Patent number: 7427636
    Abstract: The invention is related to phosphorus substituted IMPDH inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: September 23, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Thorsten Kirschberg, Hyung-Jung Pyun, William J. Watkins, Jennifer R. Zhang
  • Kinase inhibitory phosphonate analogs
    Patent number: 7417055
    Abstract: The invention is related to phosphorus substituted kinase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: August 26, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Manoj Desai, Maria Fardis, Thorsten Kirschberg, Richard L. Mackman, Sundaramoorthi Swaminathan, William J. Watkins