Abstract: The ?2-adrenergic receptor (?2AR) is a primary target in the treatment of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). Since ?-agonist treatment of airway disease can have severe side effects, compounds that attenuate the side effects of ?-agonists have been identified via their ability to inhibit ?2AR interaction with ?-arrestins. These compounds are specific for the ?2AR and effectively protect against the desensitization observed with ?-agonist treatment in model cells and airway tissue. The present disclosure provides compounds and methods for treating airway disease, such as but not limited to COPD and/or asthma.

Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: Reprocessing of a replaceable supply component may include receiving from an encoding device and using an interface communicatively coupled to the encoding device, a request blob to reprocess a replaceable supply component. The method may include in response to cryptographically verifying the request blob, extracting from the request blob, a supply identifier and raw supply data. The method further includes using the supply identifier and raw supply data, generating a reprocess structure to append or amend original manufacturing data for the replaceable supply component, and providing a response blob to the encoding device, to designate the replaceable supply component as a reprocessed supply component.

Abstract: A cleaning implement including a foot, a motor, and an eccentric mass. The foot has a foot plate and an oscillation plate movably coupled to the foot plate. The motor is coupled to at least one of the foot plate and the oscillation plate. The motor rotates about a motor axis extending at a non-perpendicular transverse angle relative to the surface. The eccentric mass is coupled to the motor to generate an oscillating force between the foot plate and the oscillation plate upon operation of the motor. The oscillating force has a planar component parallel to the oscillation plate and a perpendicular component perpendicular to the oscillation plate.

Abstract: Systems and techniques are disclosed for predicting the structural status of an object. An object model, such as a machine learning model, can be trained on sample sensor data indicating vibrations, movements, and/or other reactions of objects with known desired and undesired structural statuses to a stimulus agent, such as a puff of air. A scanning device can output a corresponding stimulus agent towards an object, capture sensor data indicating the reaction of the object to the stimulus agent, and provide the sensor data to the trained object model. Based on the sensor data indicating how the object reacted to the stimulus agent, the object model can predict whether the object has a desired structural status or an undesired structural status.

Abstract: A shower/commode wheeled chair adapted to be locatable over a commode, the shower/commode wheeled chair comprising a frame, a seat support portion, a front portion extending downwardly from the seat support portion, a back support, a shower/commode seat, wheels and a footrest coupled to the front portion.

Abstract: A video game includes a single player mode where completion of storyline objectives advances the single player storyline. The video game also includes a multiplayer mode where a plurality of players can play on an instance of a multiplayer map. Storyline objectives from the single player mode are selected and made available for completion to players in the multiplayer mode, and the single player storylines can be advanced by players completing respective storyline objectives while playing in the multiplayer mode. Combinations of storyline objectives are selected from pending storyline objectives for players connecting to a multiplayer game for compatibility with multiplayer maps. Constraints can be used to determine compatibility.

Abstract: A system includes at least one processor and at least one memory including instructions that, when executed by the at least one processor, cause the at least one processor to perform operations. The operations include providing a secure link to an auditable, machine-readable dataset to a client device of a user, the auditable, machine-readable dataset comprising data. At least one policy constraint is provided to at least a portion of the data in the dataset. In response to detecting activation of the secure link at the client device, one or both of the user and the client device is authenticated based on the policy constraint. Streaming access is provided to the auditable, machine-readable dataset in real-time.

Abstract: In an embodiment, a kiosk mounting apparatus includes a chassis, payment module, and enclosure. The chassis is configured to mount a tablet computing device. The tablet computing device includes a touch screen display and is configured to execute an interactive application. The payment module is mounted to the chassis and is configured to be communicatively coupled to the tablet computing device. The payment module is configured to detect payment data specifying an account from a user's payment device. The payment module is configured to encrypt the payment data and to communicate the encrypted payment information to the tablet computing device for processing by a payment gateway. The enclosure is mounted to the chassis and has an opening for the touch screen display. The enclosure encloses the payment module. By enclosing the payment module, the kiosk mounting apparatus encapsulates the payment module into the kiosk.

Abstract: A user can scan a QR code on a kiosk with her mobile device. Scanning the QR code will cause the mobile device to display an interface displayed on the kiosk. When a user enters information on the device corresponding information is displayed on the kiosk. In this way, a user can engage with the kiosk interface in a contactless manner.

Abstract: A user can scan a QR code on a kiosk with her mobile device. Scanning the QR code will cause the mobile device to display an interface displayed on the kiosk. When a user enters information on the device corresponding information is displayed on the kiosk. In this way, a user can engage with the kiosk interface in a contactless manner.

Abstract: A user can scan a QR code on a kiosk with her mobile device. Scanning the QR code will cause the mobile device to display an interface displayed on the kiosk. When a user enters information on the device corresponding information is displayed on the kiosk. In this way, a user can engage with the kiosk interface in a contactless manner.

Abstract: A container securing system of straps and containers. The containers are configured with a plurality of pass-through loops on side zones. The guide loops receive a strap that secures the containers together and secures them in the closed position. The securing strap is secured to the container through a locking lock positioned below the guide loop.

Abstract: Systems and techniques are disclosed for planning and performing an audit. The systems and techniques determine whether a Single Audit or a program-specific audit is to be performed for an entity, and automatically select one or more compliance procedures that are to be used during the auditing process.

Abstract: A professional services audit tool is disclosed that includes an application that performs a variety of functions such as completing certain audit planning processes/forms, offering a tailored set audit programs based on the assessed risks, allowing users to further tailor the suggested audit programs, and rendering these audit programs in a helpful format. The application also provides functionality to perform and document audit work, guide the auditor though the engagement process, isolate audit program steps by related assertions and identified risks to ensure that audit plans are tailored to specific risks, provide an engagement dashboard to view at a glance both the overall audit and for each audit area, the steps which are not yet started, in progress, or completed, and allow for the integration of generated documents to be automatically stored to, accessed from, and synchronized with various external engagement management systems.

Abstract: An adjustable mount assembly for supporting a convex mirror or other devices on the top of a cubicle/office partition wall. In one embodiment, the adjustable mount assembly comprises a supporting element having a vertical tubular member configured to securely hold a connecting means, such as a Z-bracket for supporting a convex mirror, an adjustable element insertable into the supporting element, and two clamping elements that when inserted into vertical slots in each of the supporting element and the adjustable element, form a clamping assembly that holds the adjustable mount assembly snugly in place on top of the partition wall. The adjustable mount assembly is adjustable to snugly fit over the top of any partition wall to support a convex mirror or other devices by means of an interchangeable mount adapter and may also comprise release buttons on the adjustable element to facilitate disassembly of an assembled mount assembly.

Abstract: The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.

Abstract: A method, system, and computer program product for classifying user intent based on spatial information relayed via a mobile device. Embodiments commence upon receiving a location beacon identification value originating from a location beacon, which location beacon identification value is then relayed to the server from the mobile device. The server determines a set of one or more rules based at least in part on the location beacon identification value, and then transmits at least a portion of a set of one or more rules to the mobile device, (e.g., using a mobile device carrier's infrastructure). The rules comprise triggers, and when a trigger fires, user categorization is determined and user intent is predicted. The user categorization and/or predicted user intent is used to select an advertising message.

Abstract: A temporary grounding assembly is provided that includes a ground clamp, a tensioning member, a tensioner device, a first conductor, and a ground rod. The ground clamp has a main body with a plurality of teeth that are configured to make electrical connection with an outer diameter of a pipe. The tensioning member is secured to one end of the ground clamp. The tensioner device is securable to the tensioning member and to an opposite end of the ground clamp. The first conductor is in electrical connection with the ground clamp. The ground rod is in electrical connection with the first conductor.

Abstract: A tube hanger for a very early smoke detection system is provided. The tube hanger includes a tube hook configured to receive a tube, a suspension arm having a first end extending from the tube hook and a second end, and a support coupling mechanism extending from the second end of the suspension arm. The support coupling mechanism includes a first attachment mechanism configured to be coupled to a first frame type, and a second attachment mechanism configured to be coupled to a second frame type. The tube hanger further includes a third attachment mechanism extending from the support coupling mechanism and configured to be coupled to a third frame type.