Patents by Inventor Lee Spate

Lee Spate has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High-throughput and non-invasive method to vitrify porcine embryos
    Patent number: 8852078
    Abstract: The present invention provides a practical, non-invasive, and efficient method for cryopreservation of an in-vitro-produced porcine embryo. The inventive method treats the NP (such as IVF- or NT-derived) embryo at the one-cell or cleavage stage prior to compaction with high osmolality followed by high speed centrifugation. The high osmolality treatment enlarges the periviteline space, and with centrifugation, enables the separation of the lipids from the cytoplasm. The lipid-separated embryos after high osmolality treatment have been successfully cryopreserved and later recovered and transferred to produce live offspring.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: October 7, 2014
    Assignee: The Curators of the University of Missouri
    Inventors: Randall S. Prather, Rongfeng Li, Clifton N. Murphy, Lee Spate
  • HIGH-THROUGHPUT AND NON-INVASIVE METHOD TO VITRIFY PORCINE EMBRYOS
    Publication number: 20110213198
    Abstract: The present invention provides a practical, non-invasive, and efficient method for cryopreservation of an in-vitro-produced porcine embryo. The inventive method treats the NP (such as IVF- or NT-derived) embryo at the one-cell or cleavage stage prior to compaction with high osmolality followed by high speed centrifugation. The high osmolality treatment enlarges the periviteline space, and with centrifugation, enables the separation of the lipids from the cytoplasm. The lipid-separated embryos after high osmolality treatment have been successfully cryopreserved and later recovered and transferred to produce live offspring.
    Type: Application
    Filed: August 28, 2009
    Publication date: September 1, 2011
    Applicant: The Curators of the University of Missouri
    Inventors: Randall S. Prather, Rongfeng Li, Clifton N. Murphy, Lee Spate