Patents by Inventor Lee Spence

Lee Spence has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of pleuromutilin
    Patent number: 10913703
    Abstract: The present invention relates to purification methods of pleuromutilin (I) by means of crystallisation and/or recrystallisation. The process according to the present invention is carried out in the presence of i-propylacetate.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: February 9, 2021
    Assignee: NABRIVA THERAPEUTICS GMBH
    Inventors: Werner Heilmayer, Lee Spence, Peter Hinsmann
  • PURIFICATION OF PLEUROMUTILIN
    Publication number: 20200231529
    Abstract: The present invention relates to purification methods of pleuromutilin (I) by means of crystallisation and/or recrystallisation. The process according to the present invention is carried out in the presence of i-propylacetate.
    Type: Application
    Filed: February 9, 2018
    Publication date: July 23, 2020
    Inventors: Werner HEILMAYER, Lee SPENCE, Peter HINSMANN
  • Process for the preparation of pleuromutilins
    Patent number: 9120727
    Abstract: Process for the preparation of a compound of formula I in the form of a single stereoisomer in crystalline form, comprising deprotecting the amine group in a compound of formula IIa or in a mixture of a compound of formula IIa with a compound of formula IIb and isolating a compound of formula I from the reaction mixture; compounds and salts of compounds of formula I in crystalline form; pharmaceutical compositions comprising such salts; processes for the preparation of intermediates and intermediates in a process for the preparation of a compound of formula I.
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: September 1, 2015
    Assignee: NABRIVA THERAPEUTICS AG
    Inventors: Rosemarie Riedl, Werner Heilmayer, Lee Spence
  • Enantiomerically pure amines
    Patent number: 8987498
    Abstract: A compound of formula wherein PROT is an amine protecting group and PROT? is hydrogen; or PROT and PROT? together with the nitrogen atom to which they are attached form a heterocyclic ring as an amine protecting group, and PROT? is a thiol protecting group, processes for its production, intermediates in their production and production of intermediates in stereoisomerically pure form, and their use for the production of pharmaceutically active compounds.
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: March 24, 2015
    Assignee: Nabriva Therapeutics AG
    Inventors: Rosemarie Riedl, Werner Heilmayer, Lee Spence, Atchyuta Rama Chandra Murty Bulusu
  • PROCESS FOR THE PREPARATION OF PLEUROMUTILINS
    Publication number: 20130079400
    Abstract: Process for the preparation of a compound of formula I in the form of a single stereoisomer in crystalline form, comprising deprotecting the amine group in a compound of formula IIa or in a mixture of a compound of formula IIa with a compound of formula IIb and isolating a compound of formula I from the reaction mixture; compounds and salts of compounds of formula I in crystalline form; pharmaceutical compositions comprising such salts; processes for the preparation of intermediates and intermediates in a process for the preparation of a compound of formula I.
    Type: Application
    Filed: May 23, 2011
    Publication date: March 28, 2013
    Applicant: Nabriva Therapeutics AG
    Inventors: Rosemarie Riedl, Werner Heilmayer, Lee Spence
  • ENANTIOMERICALLY PURE AMINES
    Publication number: 20130072711
    Abstract: A compound of formula wherein PROT is an amine protecting group and PROT? is hydrogen; or PROT and PROT? together with the nitrogen atom to which they are attached form a heterocyclic ring as an amine protecting group, and PROT? is a thiol protecting group, processes for its production, intermediates in their production and production of intermediates in stereoisomerically pure form, and their use for the production of pharmaceutically active compounds.
    Type: Application
    Filed: May 26, 2010
    Publication date: March 21, 2013
    Applicant: NABRIVA THERAPEUTICS AG
    Inventors: Rosemarie Riedl, Werner Heilmayer, Lee Spence, Atchyuta Rama Chandra Murty Bulusu