Patents by Inventor Lee Swem

Lee Swem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIGH-COMPLEXITY SYNTHETIC GUT BACTERIAL COMMUNITIES
    Publication number: 20230233620
    Abstract: The present invention provides high-complexity defined gut microbial communities capable of achieving substantial engraftment and having stability following human fecal community microbial challenge and methods of producing the same. Also provided are methods of using high-complexity defined gut microbial communities for the treatment of dysbiosis or a pathological condition in an animal.
    Type: Application
    Filed: May 21, 2021
    Publication date: July 27, 2023
    Inventors: Michael A. Fischbach, Ariel R. Brumbaugh, Alice G. Cheng, Dylan Dodd, Andres Jesus Aranda-Diaz, Min Wang, Feiqiao Brian Yu, Justin L. Sonnenburg, Kerwyn C. Huang, Steve Higginbottom, Sunit Jain, Xiandong Meng, Lee Swem, Dante Ricci, Joshua J. Hamilton
  • MICROBIAL CONSORTIA FOR THE TREATMENT OF DISEASE
    Publication number: 20230125976
    Abstract: The present invention provides microbial consortia capable of stable engraftment in the gastrointestinal tract of a subject, and degradation of a disease-associated metabolic substrate, and methods of using the same.
    Type: Application
    Filed: March 10, 2021
    Publication date: April 27, 2023
    Inventors: Lee Swem, Dante Ricci, Ariel R. Brumbaugh, John Cremin, Joshua J. Hamilton, Shital Tripathi, Lauren Wong, Heather Romasko, Racquel Bracken, Emily Drabant Conley, Anthony Rush
  • ANTI-HEMAGGLUTININ ANTIBODIES AND METHODS OF USE
    Publication number: 20190023770
    Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.
    Type: Application
    Filed: January 18, 2018
    Publication date: January 24, 2019
    Applicant: Genentech, Inc.
    Inventors: Min Xu, Mercedesz Balazs, Ning Chai, Nancy Y. Chiang, Henry Chiu, Zhaoyu Jin, Zhonghua Lin, Patrick Lupardus, Gerald Nakamura, Hyunjoo Park, Lee Swem
  • Anti-hemagglutinin antibodies and methods of use
    Patent number: 9908931
    Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: March 6, 2018
    Assignee: GENENTECH, INC.
    Inventors: Min Xu, Mercedesz Balazs, Ning Chai, Nancy Chiang, Henry Chiu, Zhaoyu Jin, Zhonghua Lin, Patrick Lupardus, Gerald r. Nakamura, Hyunjoo Park, Lee Swem
  • Influenza A H7N9 virus therapies
    Patent number: 9879066
    Abstract: The present invention provides anti-influenza A virus antibodies effective at binding, neutralizing, and treating influenza A H7N9 virus, compositions comprising such antibodies, and methods of using the same.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: January 30, 2018
    Assignee: Genentech, Inc.
    Inventors: Ning Chai, Jacqueline McBride, Lee Swem
  • ANTI-INFLUENZA B VIRUS HEMAGGLUTININ ANTIBODIES AND METHODS OF USE
    Publication number: 20170320937
    Abstract: The present invention provides anti-influenza B virus hemagglutinin antibodies, compositions comprising anti-influenza B virus hemagglutinin antibodies, and methods of using the same.
    Type: Application
    Filed: July 24, 2017
    Publication date: November 9, 2017
    Applicant: Genentech, Inc.
    Inventors: Lee Swem, Min Xu, Mercedesz Balazs, Ning Chai, Nancy Chiang, Henry Chiu, Zhonghua Lin, Gerald R. Nakamura, Hyunjoo Park
  • Anti-influenza B virus hemagglutinin antibodies and methods of use
    Patent number: 9745365
    Abstract: The present invention provides anti-influenza B virus hemagglutinin antibodies, compositions comprising anti-influenza B virus hemagglutinin antibodies, and methods of using the same.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: August 29, 2017
    Assignee: Genentech, Inc.
    Inventors: Lee Swem, Min Xu, Mercedesz Balazs, Ning Chai, Nancy Chiang, Henry Chiu, Zhonghua Lin, Gerald R. Nakamura, Hyunjoo Park
  • INFLUENZA A H7N9 VIRUS THERAPIES
    Publication number: 20170114121
    Abstract: The present invention provides anti-influenza A virus antibodies effective at binding, neutralizing, and treating influenza A H7N9 virus, compositions comprising such antibodies, and methods of using the same.
    Type: Application
    Filed: July 21, 2016
    Publication date: April 27, 2017
    Applicant: Genentech, Inc.
    Inventors: Ning Chai, Jacqueline McBride, Lee Swem
  • Anti-hemagglutinin antibodies and methods of use
    Patent number: 9598481
    Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: March 21, 2017
    Assignee: Genetech, Inc.
    Inventors: Min Xu, Mercedesz Balazs, Ning Chai, Nancy Chiang, Henry Chiu, Zhonghua Lin, Patrick Lupardus, Gerald R. Nakamura, Hyunjoo Park, Lee Swem
  • Inhibition of quorum sensing-mediated processes in bacteria
    Patent number: 9415040
    Abstract: Methods are provided for identifying molecules that can be used to positively and negatively manipulate quorum-sensing-mediated communication to control bacterial behavior. Small-molecule antagonists that disrupt quorum-sensing-mediated activities are identified. Methods are provided for disrupting detection of acyl-homoserine lactone autoinducer in Gram-negative bacteria by contacting the bacteria with the antagonists. Methods of inhibiting quorum sensing-mediated activity in Gram-negative bacteria are provided wherein the activity is pathogenicity, bioluminescence, siderophore production, type III secretion, or metalloprotease production.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: August 16, 2016
    Assignee: The Trustees of Princeton University
    Inventors: Bonnie Bassler, Lee Swem
  • ANTI-HEMAGGLUTININ ANTIBODIES AND METHODS OF USE
    Publication number: 20160168230
    Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.
    Type: Application
    Filed: February 12, 2016
    Publication date: June 16, 2016
    Applicant: Genentech, Inc.
    Inventors: Min XU, Mercedesz BALAZS, Ning CHA, Nancy CHIANG, Henry CHIU, Zhaoyu JIN, Zhonghua LIN, Patrick LUPARDUS, Gerald R. NAKAMURA, Hyunjoo PARK, Lee SWEM
  • Anti-hemagglutinin antibodies and methods of use
    Patent number: 9284365
    Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: March 15, 2016
    Assignee: Genentech, Inc.
    Inventors: Min Xu, Mercedesz Balazs, Ning Chai, Nancy Chiang, Henry Chiu, Zhonghua Lin, Patrick Lupardus, Gerald R. Nakamura, Hyunjoo Park, Lee Swem
  • ANTI-INFLUENZA B VIRUS HEMAGGLUTININ ANTIBODIES AND METHODS OF USE
    Publication number: 20150274812
    Abstract: The present invention provides anti-influenza B virus hemagglutinin antibodies, compositions comprising anti-influenza B virus hemagglutinin antibodies, and methods of using the same.
    Type: Application
    Filed: March 26, 2015
    Publication date: October 1, 2015
    Applicant: GENENTECH, INC.
    Inventors: Lee Swem, Min Xu, Mercedesz Balazs, Ning Chai, Nancy Chiang, Henry Chiu, Zhonghua Lin, Gerald R. Nakamura, Hyunjoo Park
  • ANTI-HEMAGGLUTININ ANTIBODIES AND METHODS OF USE
    Publication number: 20150259400
    Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.
    Type: Application
    Filed: May 29, 2015
    Publication date: September 17, 2015
    Applicant: GENENTECH, INC.
    Inventors: Min Xu, Mercedesz Balazs, Ning Chai, Nancy Chiang, Henry Chiu, Zhonghua Lin, Patrick Lupardus, Gerald R. Nakamura, Hyunjoo Park, Lee Swem
  • INHIBITION OF QUORUM SENSING-MEDIATED PROCESSES IN BACTERIA
    Publication number: 20150238475
    Abstract: Methods are provided for identifying molecules that can be used to positively and negatively manipulate quorum-sensing-mediated communication to control bacterial behavior. Small-molecule antagonists that disrupt quorum-sensing-mediated activities are identified. Methods are provided for disrupting detection of acyl-homoserine lactone autoinducer in Gram-negative bacteria by contacting the bacteria with the antagonists. Methods of inhibiting quorum sensing-mediated activity in Gram-negative bacteria are provided wherein the activity is pathogenicity, bioluminescence, siderophore production, type III secretion, or metalloprotease production.
    Type: Application
    Filed: May 8, 2015
    Publication date: August 27, 2015
    Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Bonnie Bassler, Lee Swem
  • Inhibition of quorum sensing-mediated processes in bacteria
    Patent number: 9045476
    Abstract: Methods are provided for identifying molecules that can be used to positively and negatively manipulate quorum-sensing-mediated communication to control bacterial behavior. Small-molecule antagonists that disrupt quorum-sensing-mediated activities are identified. Methods are provided for disrupting detection of acyl-homoserine lactone autoinducer in Gram-negative bacteria by contacting the bacteria with the antagonists. Methods of inhibiting quorum sensing-mediated activity in Gram-negative bacteria are provided wherein the activity is pathogenicity, bioluminescence, siderophore production, type III secretion, or metalloprotease production.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: June 2, 2015
    Assignee: The Trustees of Princeton University
    Inventors: Bonnie Bassler, Lee Swem
  • ANTI-HEMAGGLUTININ ANTIBODIES AND METHODS OF USE
    Publication number: 20140248286
    Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.
    Type: Application
    Filed: May 12, 2014
    Publication date: September 4, 2014
    Applicant: Genentech, Inc.
    Inventors: Min Xu, Mercedesz Balazs, Ning Chai, Nancy Chiang, Henry Chiu, Zhonghua Lin, Patrick Lupardus, Gerald R. Nakamura, Hyunjoo Park, Lee Swem
  • ANTI-HEMAGGLUTININ ANTIBODIES AND METHODS OF USE
    Publication number: 20140161822
    Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.
    Type: Application
    Filed: November 12, 2013
    Publication date: June 12, 2014
    Applicant: Genentech, Inc.
    Inventors: Min XU, Mercedesz BALAZS, Ning CHAI, Nancy Chiang, Henry CHIU, Zhaoyu JIN, Zhonghua LIN, Patrick LUPARDUS, Gerald R. NAKAMURA, Hyunjoo PARK, Lee SWEM
  • ENRICHMENT OF ANTIGEN-SPECIFIC PLASMABLASTS
    Publication number: 20140134638
    Abstract: The present invention relates to methods for enrichment of antigen-specific plasmablasts. The methods are useful for the identification of antibodies, including rare antibodies which recognize more than one antigen.
    Type: Application
    Filed: November 12, 2013
    Publication date: May 15, 2014
    Applicant: Genentech, Inc.
    Inventors: Juan ZHANG, Mercedesz BALAZS, Ning CHAI, Henry CHIU, Wyne Pun LEE, Zhonghua LIN, Patrick LUPARDUS, Lee SWEM
  • INHIBITION OF QUORUM SENSING-MEDIATED PROCESSES IN BACTERIA
    Publication number: 20140100242
    Abstract: Methods are provided for identifying molecules that can be used to positively and negatively manipulate quorum-sensing-mediated communication to control bacterial behavior. Small-molecule antagonists that disrupt quorum-sensing-mediated activities are identified. Methods are provided for disrupting detection of acyl-homoserine lactone autoinducer in Gram-negative bacteria by contacting the bacteria with the antagonists. Methods of inhibiting quorum sensing-mediated activity in Gram-negative bacteria are provided wherein the activity is pathogenicity, bioluminescence, siderophore production, type III secretion, or metalloprotease production.
    Type: Application
    Filed: September 17, 2013
    Publication date: April 10, 2014
    Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Bonnie Bassler, Lee Swem