Patents by Inventor Lee Weng
Lee Weng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140121568Abstract: An ultrasound system used for both imaging and delivery high intensity ultrasound energy therapy to treatment sites and a method for treating tumors and other undesired tissue within a patient's body with an ultrasound device. The ultrasound device has an ultrasound transducer array disposed on a distal end of an elongate, relatively thin shaft. In one form of the invention, the transducer array is disposed within a liquid-filled elastomeric material that more effectively couples ultrasound energy into the tumor, that is directly contacted with the device. Using the device in a continuous wave mode, a necrotic zone of tissue having a desired size and shape (e.g., a necrotic volume selected to interrupt a blood supply to a tumor) can be created by controlling at least one of the f-number, duration, intensity, and direction of the ultrasound energy administered. This method speeds the therapy and avoids continuously pausing to enable intervening normal tissue to cool.Type: ApplicationFiled: January 6, 2014Publication date: May 1, 2014Applicant: Kona Medical, Inc.Inventors: Lee Weng, David M. Perozek, Jimin Zhang
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Patent number: 8622937Abstract: An ultrasound system used for both imaging and delivery high intensity ultrasound energy therapy to treatment sites and a method for treating tumors and other undesired tissue within a patient's body with an ultrasound device. The ultrasound device has an ultrasound transducer array disposed on a distal end of an elongate, relatively thin shaft. In one form of the invention, the transducer array is disposed within a liquid-filled elastomeric material that more effectively couples ultrasound energy into the tumor, that is directly contacted with the device. Using the device in a continuous wave mode, a necrotic zone of tissue having a desired size and shape (e.g., a necrotic volume selected to interrupt a blood supply to a tumor) can be created by controlling at least one of the f-number, duration, intensity, and direction of the ultrasound energy administered. This method speeds the therapy and avoids continuously pausing to enable intervening normal tissue to cool.Type: GrantFiled: October 8, 2008Date of Patent: January 7, 2014Assignee: Kona Medical, Inc.Inventors: Lee Weng, David M. Perozek, Jimin Zhang
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Patent number: 8447526Abstract: The present invention provides methods and computer programs for detecting variations in measurements of a biological variable, e.g., variations in cell viability, under different conditions, e.g., with or without treatment of a drug, under the treatments of different drugs, or under different environmental conditions. The methods and programs of the invention determine a metric of difference between measurements under different condition, and make use of predetermined errors of the measurements, e.g., errors determined from an error model, to estimate the errors in the metric of difference. Such an approach provides a more accurate estimate of the errors of measurements, which, in turn, provides a more accurate estimate of the error of the difference metric.Type: GrantFiled: May 23, 2006Date of Patent: May 21, 2013Assignee: Microsoft CorporationInventors: Lee Weng, Hongyue Dai, Steven R. Bartz
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Patent number: 8388535Abstract: An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel.Type: GrantFiled: January 21, 2011Date of Patent: March 5, 2013Assignee: Kona Medical, Inc.Inventors: Lee Weng, David M. Perozek, Jimin Zhang
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Patent number: 8277398Abstract: An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel.Type: GrantFiled: February 11, 2011Date of Patent: October 2, 2012Assignee: Kona Medical, Inc.Inventors: Lee Weng, David M. Perozek, Jimin Zhang
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Patent number: 8275185Abstract: An image processing system extracts parts or characteristics of interest from prepared biological samples One suitable use of the image processing system is to find biomarkers. But many other suitable uses are possible. Some components of the system include image preprocessing (data interpolation, retention time alignment, image noise filtering, background estimation, and formation of a composite image); image feature extraction (peaks, isotope groups, and charge groups); and computation of feature characteristics and expression statistics, differential expression, and non-differential expression. Outputs of the system include a candidate list of parts or characteristic of interest for aiding further discovery.Type: GrantFiled: January 13, 2011Date of Patent: September 25, 2012Assignee: Microsoft CorporationInventors: Lee Weng, Andrey Bondarenko, Silvia C. Vega, Ernst S. Henle, Brandon T. Hunt, Alexander Spiridonov
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Publication number: 20120108966Abstract: Methods for applying heat to a region proximate a blood vessel are disclosed. In one embodiment, a method can include generating an imaging ultrasound beam adapted to image a blood vessel target and receiving a reflection of the imaging ultrasound beam. The method can also include producing an output signal in response to the reflection of the imaging ultrasonic beam and processing the output signal to identify a location of a treatment zone proximate an outer wall of the blood vessel. Therapeutic energy can be applied to the treatment zone. In some embodiments, the therapeutic ultrasound energy beam can be moved to over-scan the treatment zone. Other methods are also disclosed.Type: ApplicationFiled: January 5, 2012Publication date: May 3, 2012Applicant: Kona Medical, Inc.Inventors: Lee Weng, David M. Perozek, Jimin Zhang
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Publication number: 20120108967Abstract: Methods for applying heat to a region proximate a blood vessel are disclosed. In one embodiment, a method can include generating an imaging ultrasound beam adapted to image a blood vessel target and receiving a reflection of the imaging ultrasound beam. The method can also include producing an output signal in response to the reflection of the imaging ultrasonic beam and processing the output signal to identify a location of a treatment zone proximate an outer wall of the blood vessel. Therapeutic energy can be applied to the treatment zone. In some embodiments, the therapeutic ultrasound energy beam can be moved to over-scan the treatment zone. Other methods are also disclosed.Type: ApplicationFiled: January 9, 2012Publication date: May 3, 2012Applicant: Kona Medical, Inc.Inventors: Lee Weng, David M. Perozek, Jimlin Zhang
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Patent number: 8137274Abstract: Methods for applying heat to a region proximate a blood vessel are disclosed. In one embodiment, a method can include generating an imaging ultrasound beam adapted to image a blood vessel target and receiving a reflection of the imaging ultrasound beam. The method can also include producing an output signal in response to the reflection of the imaging ultrasonic beam and processing the output signal to identify a location of a treatment zone proximate an outer wall of the blood vessel. Therapeutic energy can be applied to the treatment zone. In some embodiments, the therapeutic ultrasound energy beam can be moved to over-scan the treatment zone. Other methods are also disclosed.Type: GrantFiled: February 11, 2011Date of Patent: March 20, 2012Assignee: Kona Medical, Inc.Inventors: Lee Weng, David M Perozek, Jimin Zhang
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Publication number: 20120059258Abstract: An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture.Type: ApplicationFiled: September 26, 2011Publication date: March 8, 2012Applicant: Kona Medical, Inc.Inventors: Lee Weng, David M. Perozek, Jimin Zhang
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Patent number: 7996155Abstract: The present invention provides improved ANOVA methods for analyzing measured data and transformed data. The improved ANOVA method takes two data types as its input, one is the measurements, the other is a predetermined error associated with the measurements. The latter can come from a technology/platform-specific error model. Because of the additional input information, the statistical power is increased. The methods of the invention is particularly useful for analyzing gene or protein expression data.Type: GrantFiled: January 22, 2003Date of Patent: August 9, 2011Assignee: Microsoft CorporationInventor: Lee Weng
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Publication number: 20110178445Abstract: An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel.Type: ApplicationFiled: February 11, 2011Publication date: July 21, 2011Applicant: Kona Medical, Inc.Inventors: Lee Weng, David M. Perozek, Jimin Zhang
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Publication number: 20110178403Abstract: An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel.Type: ApplicationFiled: February 11, 2011Publication date: July 21, 2011Applicant: Kona Medical, Inc.Inventors: Lee Weng, David M. Perozek, Jimin Zhang
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Publication number: 20110118602Abstract: An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel.Type: ApplicationFiled: January 21, 2011Publication date: May 19, 2011Applicant: Kona Medical, Inc.Inventors: Lee Weng, David M. Perozek, Jimin Zhang
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Publication number: 20110110569Abstract: An image processing system extracts parts or characteristics of interest from prepared biological samples One suitable use of the image processing system is to find biomarkers. But many other suitable uses are possible. Some components of the system include image preprocessing (data interpolation, retention time alignment, image noise filtering, background estimation, and formation of a composite image); image feature extraction (peaks, isotope groups, and charge groups); and computation of feature characteristics and expression statistics, differential expression, and non-differential expression. Outputs of the system include a candidate list of parts or characteristic of interest for aiding further discovery.Type: ApplicationFiled: January 13, 2011Publication date: May 12, 2011Applicant: MICROSOFT CORPORATIONInventors: Lee Weng, Andrey Bondarenko, Silvia C. Vega, Ernst S. Henle, Brandon T. Hunt, Alexander Spiridonov
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Publication number: 20110066085Abstract: An ultrasound system used for both imaging and delivery high intensity ultrasound energy therapy to treatment sites and a method for treating tumors and other undesired tissue within a patient's body with an ultrasound device. The ultrasound device has an ultrasound transducer array disposed on a distal end of an elongate, relatively thin shaft. In one form of the invention, the transducer array is disposed within a liquid-filled elastomeric material that more effectively couples ultrasound energy into the tumor, that is directly contacted with the device. Using the device in a continuous wave mode, a necrotic zone of tissue having a desired size and shape (e.g., a necrotic volume selected to interrupt a blood supply to a tumor) can be created by controlling at least one of the f-number, duration, intensity, and direction of the ultrasound energy administered. This method speeds the therapy and avoids continuously pausing to enable intervening normal tissue to cool.Type: ApplicationFiled: November 22, 2010Publication date: March 17, 2011Applicant: Kona Medical, Inc.Inventors: Lee Weng, David M. Perozek, Jimin Zhang
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Patent number: 7894650Abstract: An image processing system extracts parts or characteristics of interest from prepared biological samples One suitable use of the image processing system is to find biomarkers. But many other suitable uses are possible. Some components of the system include image preprocessing (data interpolation, retention time alignment, image noise filtering, background estimation, and formation of a composite image); image feature extraction (peaks, isotope groups, and charge groups); and computation of feature characteristics and expression statistics, differential expression, and non-differential expression. Outputs of the system include a candidate list of parts or characteristic of interest for aiding further discovery.Type: GrantFiled: November 13, 2006Date of Patent: February 22, 2011Assignee: Microsoft CorporationInventors: Lee Weng, Andrey Bondarenko, Silvia C. Vega, Ernst S. Henle, Brandon Hunt, Alexander Spiridonov
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Patent number: 7881872Abstract: The present invention provides methods for analyzing multi-channel profiles. In the method of the invention, systematic cross-profile (cross-experiment) errors among a plurality of multi-channel profiles having a common reference channel are estimated using profiles of the common reference channel. The cross-profile errors are then removed from profiles of the experiment channels, e.g., by subtracting the error from the experiment profile. The obtained error-corrected experiment channel data can then be used in comparison with each other, e.g., in generating virtual differential profiles between pairs of experiment channels. The method of the invention is particularly useful in analyzing multi-channel expression profiles obtained in microarray measurements.Type: GrantFiled: March 12, 2004Date of Patent: February 1, 2011Assignee: Microsoft CorporationInventor: Lee Weng
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Publication number: 20110021913Abstract: An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel.Type: ApplicationFiled: October 1, 2010Publication date: January 27, 2011Applicant: Kona Medical, Inc.Inventors: Lee Weng, David M. Perozek, Jimin Zhang
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Publication number: 20100310138Abstract: A technique for finding paired isotope groups of peptides, metabolic materials, or other materials is executed without having to identify features. Any suitable isotopic labeling methods, such as SILAC or ICAT, can be used. The technique can identify isotope pairs by pairing heavy and light labeled peptides based on mono-isotopes. The technique searches for isotope groups that have retention time and mass/charge within given tolerances, adjustable by users. Multiple label sites are supported as well as reverse-labeling to inhibit or reduce biases. Multiple replicates can be merged into a composite image.Type: ApplicationFiled: June 4, 2008Publication date: December 9, 2010Inventors: Andrey Bondarenko, Alexander Spiridonov, Lee Weng