Patents by Inventor Lee Ann Higgins

Lee Ann Higgins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of computational and experimental data to model organic compound reactivity in cytochrome P450 mediated reactions and to optimize the design of pharmaceuticals
    Patent number: 6643591
    Abstract: The present invention is directed to the use of computational and other experimental data in the design of new pharmaceuticals, and in predicting the metabolism and toxicological profiles thereof. Computational and other information is used to further understand drug metabolism and toxicology, particulary in relation to monooxygenase enzymes, such as those of the CYP system, that are involved in drug metabolism. Information derived according to the practice of the invention is useful in determining the clearance or half-life of drugs, and the nature and toxicity of byproducts resulting from their metabolism. The invention provides novel and powerful new approaches to drug design.
    Type: Grant
    Filed: August 5, 1999
    Date of Patent: November 4, 2003
    Assignees: University of Pittsburgh, University of Rochester
    Inventors: Kenneth R. Korzekwa, Jeffrey P. Jones, Lee Ann Higgins
  • Use of computational and experimental data to model organic compound reactivity in cytochrome P450 mediated reactions and to optimize the design of pharmaceuticals
    Publication number: 20030120470
    Abstract: The present invention is directed to the use of computational and other experimental data in the design of new pharmaceuticals, and in predicting the metabolism and toxicological profiles thereof. Computational and other information is used to further understand drug metabolism and toxicology, particulary in relation to monooxygenase enzymes, such as those of the CYP system, that are involved in drug metabolism. Information derived according to the practice of the invention is useful in determining the clearance or half-life of drugs, and the nature and toxicity of byproducts resulting from their metabolism. The invention provides novel and powerful new approaches to drug design.
    Type: Application
    Filed: August 8, 2002
    Publication date: June 26, 2003
    Applicant: University of Pittsburgh and University of Rochester
    Inventors: Kenneth R. Korzekwa, Jeffrey P. Jones, Lee Ann Higgins