Patents by Inventor Leen Thielemans

Leen Thielemans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120184537
    Abstract: The invention relates to a novel class of [1,4]-benzodiazepine derivatives, processes for their preparation, intermediates usable in these processes, and pharmaceutical compositions containing the compounds. Other aspects of the invention are directed to the use of said [1,4]-benzodiazepine derivatives in therapy based on the capability of said compounds to interfere with the binding of the peptide hormone, vasopressin, to its receptors. In particular as vasopressin V2 receptor antagonists and therefore useful for treating involving increased vascular resistance, cardiac insufficiency, and water retention.
    Type: Application
    Filed: September 23, 2010
    Publication date: July 19, 2012
    Inventors: Ann Meulemans, Karel Lavrijsen, Marina Cools, Erik Keller, Igor Alexnadrovich Mezine, Leen Thielemans, Maarten VAn Geffen
  • Publication number: 20110313153
    Abstract: The invention relates generally to the treatment of diseases of the respiratory system such as asthma and chronic obstructive pulmonary disease. More particularly, the present invention relates to methods of treating and preventing asthmatic airway inflammation. The treatment involves the administration of a 5-HT4 receptor antagonist to the subject in need thereof; more in particular the administration of aroylated 4-aminomethylpiperidine derivatives as defined herein. Other aspects of the invention are directed to compositions for treating or preventing respiratory disorders, including pharmaceutical compositions.
    Type: Application
    Filed: January 28, 2010
    Publication date: December 22, 2011
    Inventors: Ann Meulemans, Leen Thielemans, Joris De Maeyer, Jan Schuurkes