Patents by Inventor Leena Valmu
Leena Valmu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11442064Abstract: The present invention includes a novel method and system for identification of microorganisms in samples that proteins and other biological material from non-microorganism sources (e.g., proteins of mammalian origin) that can interfere with identification of the microorganisms. The methods and systems described herein include use of a single-use chromatography medium to purify intact proteins prior to mass spectrometry analysis. The chromatography medium and the methods described herein can rapidly and efficiently remove of a substantial portion of interfering biological material (e.g., mammalian proteins) from a crude cell lysate while preserving high signal strength and removing enough of the interfering protein(s) to allow for identification of the microorganism(s) by mass spectrometry analysis.Type: GrantFiled: August 24, 2017Date of Patent: September 13, 2022Assignee: Thermo Fisher Scientific OYInventors: Mikko Koskinen, Leena Valmu, Joni Rannisto, Kelly Flook, Roger Grist, Anssi Rantakari
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Publication number: 20190212338Abstract: The present invention includes a novel method and system for identification of microorganisms in samples that proteins and other biological material from non-microorganism sources (e.g., proteins of mammalian origin) that can interfere with identification of the microorganisms. The methods and systems described herein include use of a single-use chromatography medium to purify intact proteins prior to mass spectrometry analysis. The chromatography medium and the methods described herein can rapidly and efficiently remove of a substantial portion of interfering biological material (e.g., mammalian proteins) from a crude cell lysate while preserving high signal strength and removing enough of the interfering protein(s) to allow for identification of the microorganism(s) by mass spectrometry analysis.Type: ApplicationFiled: August 24, 2017Publication date: July 11, 2019Inventors: Mikko KOSKINEN, Leena VALMU, Joni RANNISTO, Kelly FLOOK, Roger GRIST, Anssi RANTAKARI
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Patent number: 9696284Abstract: Described are extraction columns and systems that include extraction columns. The extraction column includes a column body that has a reservoir portion, an extraction media portion, and a collar portion. The reservoir portion includes an inlet and a reservoir. The extraction media portion includes an elongated sleeve having an inner surface defining a cavity. The extraction media portion has an inlet end in fluid communication with the reservoir and an outlet end. An extraction medium is disposed in the cavity of the elongated sleeve. The collar portion extends axially in a common direction with the elongated sleeve. The collar portion has a terminal end which is spaced apart from the outlet end of the elongated sleeve and which extends axially at least to a plane defined by the outlet end of the elongated sleeve.Type: GrantFiled: June 10, 2015Date of Patent: July 4, 2017Assignee: Thermo Fisher Scientific OyInventors: Joni Rannisto, Kelly Flook, Leena Valmu, Ville Saarainen, Suvi Ravela, Johan Finell
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Publication number: 20160363565Abstract: Described are extraction columns and systems that include extraction columns. The extraction column includes a column body that has a reservoir portion, an extraction media portion, and a collar portion. The reservoir portion includes an inlet and a reservoir. The extraction media portion includes an elongated sleeve having an inner surface defining a cavity. The extraction media portion has an inlet end in fluid communication with the reservoir and an outlet end. An extraction medium is disposed in the cavity of the elongated sleeve. The collar portion extends axially in a common direction with the elongated sleeve. The collar portion has a terminal end which is spaced apart from the outlet end of the elongated sleeve and which extends axially at least to a plane defined by the outlet end of the elongated sleeve.Type: ApplicationFiled: June 10, 2015Publication date: December 15, 2016Inventors: Joni Rannisto, Kelly Flook, Leena Valmu, Ville Saarainen, Suvi Ravela, Johan Finell
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Publication number: 20160215256Abstract: The invention is directed to a method and kit to control and modify the status of cells, such as human stem cells, by changing their glycosylation, in particular sialylation and fucosylation, levels in a reaction condition where culture medium reagents, such as divalent cations, are present and cells are kept non-adherent. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.Type: ApplicationFiled: December 29, 2015Publication date: July 28, 2016Inventors: Johanna Nystedt, Heidi Anderson, Leena Valmu, Jari Natunen, Tero Satomaa
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Patent number: 9234169Abstract: The invention is directed to a method and kit to control and modify the status of cells, such as human stem cells, by changing their glycosylation, in particular sialylation and fucosylation, levels in a reaction condition where culture medium reagents, such as divalent cations, are present and cells are kept non-adherent. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.Type: GrantFiled: July 16, 2009Date of Patent: January 12, 2016Assignee: Glykos FinlandInventors: Johanna Nystedt, Heidi Anderson, Leena Valmu, Jari Natunen, Tero Satomaa
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Publication number: 20130034901Abstract: The present invention relates to a stem cell and/or a population thereof having a specific profile of cell surface proteins and/or proteoglycans. The present invention also relates to use of a proteolytic enzyme in the modification of the cell surface of a stem cell. The present invention further relates to a method of modifying the cell surface of a stem cell by treatment with a proteolytic enzyme.Type: ApplicationFiled: April 6, 2011Publication date: February 7, 2013Applicant: SUOMEN PUNAINEN RISTI VERIPALVELUInventors: Johanna Nystedt, Tanja Hakkarainen, Petri Lehenkari, Erja Kerkelä, Leena Valmu
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Publication number: 20120129712Abstract: A complex of Tra-antibody bound to an isolated glycan comprising type I—N-acetyllactosamine comprising target structure, and methods and uses utilizing said complex.Type: ApplicationFiled: April 26, 2010Publication date: May 24, 2012Applicants: GLYKOS FINLAND OY, SUOMEN PUNAINEN RISTI, VERIPALVELUInventors: Tero Satomaa, Suvi Natunen, Leena Valmu, Jari Natunen
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Publication number: 20110143373Abstract: The invention describes novel reagents that can be applied for analysis of the quality of human cells. The method evaluates the integrity of the plasma membrane of the cells by detecting novel glyco structures found only intracellularly. The method can be applied, for example, to demonstrate exposure of therapeutic cell preparation to potentially harmful conditions. It can also be used as a quality control tool in methods in which intact cell membrane is essential and it can be applied in separation of damaged cells from non- damaged.Type: ApplicationFiled: July 16, 2009Publication date: June 16, 2011Applicants: SUOMEN PUNAINEN RISTI, VERIPALVELU, GLYKOS FINLAND LTDInventors: Tia Hirvonen, Annika Kotovuori, Virve Pitkanen, Suvi Natunen, Johanna Nystedt, Sari Tiitinen, Leena Valmu, Jari Natunen
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Publication number: 20110136203Abstract: The invention is directed to a method and kit to control and modify the status of cells, such as human stem cells, by changing their glycosylation, in particular sialylation and fucosylation, levels in a reaction condition where culture medium reagents, such as divalent cations, are present and cells are kept non-adherent. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.Type: ApplicationFiled: July 16, 2009Publication date: June 9, 2011Applicants: SUOMEN PUNAINEN RISTI, VERIPALVELU, GLYKOS FINLAND LTDInventors: Johanna Nystedt, Heidi Anderson, Leena Valmu, Jari Natunen, Tero Satomaa
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Publication number: 20110045497Abstract: The invention is directed to the analysis of novel acidic glycan markers of several types of human cells. The analysis is performed by mass spectrometry or specific binder molecules.Type: ApplicationFiled: March 7, 2008Publication date: February 24, 2011Applicants: SUOMEN PUNAINEN RISTI, VERIPALVELU, GLYKOS FINLAND LTD.Inventors: Suvi Natunen, Tero Satomaa, Jari Natunen, Leena Valmu, Virve Pitkänen
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Publication number: 20100292095Abstract: This invention relates to antibody engineering technology. More particularly, the present invention relates to human IgM antibodies and derivatives thereof, which have novel binding specificity with regard to several oligosaccharide sequences and/or xenoantigenic sialic acid residue. The present invention also relates to processes for making and engineering such novel saccharide and/or NeuGc-binding monoclonal antibodies and to methods for using these antibodies and derivatives thereof in the field of immunodiagnostics, enabling qualitative and quantitative determination of xenoantigenic NeuGc in biological and raw material samples, as well as in immunotherapy, enabling blocking of xenoantigenic NeuGc in patients.Type: ApplicationFiled: November 10, 2008Publication date: November 18, 2010Applicants: SUOMEN PUNAINEN RISTI, VERIPALVELU, GLYKOS FINLAND OYInventors: Marja-Leena Laukkanen, Kristiina Takkinen, Jari Natunen, Tero Satomaa, Jaakko Parkkinen, Leena Valmu, Sari Tiitinen, Suvi Natunen
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Publication number: 20100145032Abstract: The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.Type: ApplicationFiled: January 18, 2008Publication date: June 10, 2010Applicants: Suomen Punainen Risti, Veripalelu, Glykos Finland Ltd.Inventors: Jarmo Laine, Tero Satomaa, Jari Natunen, Annamari Heiskanen, Maria Blomqvist, Anne Olonen, Juhani Saarinin, Sari Tiitinen, Ulla Impola, Milla Mikkola, Hanna Salo, Olli Aitio, Leena Valmu, Suvi Natunen, Heidi Anderson, Virve Pitkänen, Jukka Partanen, Taina Jaatinen, Minna Tiitanen, Tia Hirvonen
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Publication number: 20100068806Abstract: The present invention provides methods and materials to modulate and grow stem cells by contacting stem cells with a binder recognizing terminal glycan structures of stem cells. The modulation can be morphological change, change in differentiation status, biological status or adherence. The materials provided in the present invention are also useful to screen such a binding agents and binders.Type: ApplicationFiled: January 18, 2008Publication date: March 18, 2010Applicants: SUOMEN PUNAINEN RISTI, VERIPALVELU, Glykos Finland Ltd.Inventors: Jarmo Laine, Tero Satomaa, Jari Natunen, Annamari Heiskanen, Maria Blomqvist, Anne Olonen, Juhani Saarinen, Sari Tiitiene, Ulla Impola, Milla Mikkola, Leena Valmu, Minna Tiittanen
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Publication number: 20100047827Abstract: The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.Type: ApplicationFiled: January 18, 2008Publication date: February 25, 2010Applicants: SUOMEN PUNAINEN RISTI, VERIPALVELU, GLYKOS FINLAND LTD.Inventors: Jarmo Laine, Tero Satomaa, Jari Natunen, Annamari Heiskanen, Maria Blomqvist, Anne Olonen, Juhani Saarinen, Sari Titinen, Ulla Impola, Olli Aitio, Leena Valmu, Ulla Impola, Olli Aitio, Leena Valmu, Suvi Natunen, Hanna Salo
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Publication number: 20100028913Abstract: The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.Type: ApplicationFiled: January 18, 2008Publication date: February 4, 2010Applicants: SUOMEN PUNAINEN RISTI, VERIPALVELU, Glykos Finland Ltd.Inventors: Jarmo Laine, Tero Satomaa, Jari Natunen, Annamari Heiskanen, Maria Blomqvist, Anne Olonen, Juhani Saarinen, Sari Titinen, Ulla Impola, Olli Aitio, Leena Valmu, Heidi Anderson, Virve Pitkänen, Jukka Partanen, Taina Jaatinen