Abstract: The invention relates to identification of novel sequences associated with cervical cancer, probes and kits for the identification of said sequences, and vaccines suitable for vaccination against new cancer causing HPV types.

Abstract: The present invention relates to a method for detecting or detecting and identifying rotavirus in a biological sample. In particular, the invention relates to a detection method comprising contacting the nucleic acids from the sample or derived from the sample with at least one VP4 and/or VP7 universal probes in the context of a solid support and detecting any type-specific hybridisation. The invention further relates to a detection or detection followed by typing method comprising contacting the nucleic acids from the sample or derived from the sample with at least one P type-specific and G type-specific probes in the context of a solid support and detecting any type-specific hybridisation. The invention also relates to primers and probes used therein and to diagnostic kits.

Abstract: A method for identification of an HPV16 lineage group in a sample, comprising contacting such nucleic acid simultaneously with three probes, each probe being capable of specific hybridization across positions 143 and 145 of a HPV 16 genome.

Abstract: The invention relates to materials and methods method for detection and/or typing of any HPV nucleic acid possibly present in a biological sample, the method comprising the steps of: (i) amplification of a polynucleic acid fragment comprising or consisting of the B region of any HPV nucleic acid in the sample, said B region being indicated in FIG. 1, and (ii) contacting any amplified fragments from step (i) with at least one probe capable of specific hybridization with the B region of HPV, said B region being indicated in FIG. 1.

Abstract: The present invention relates to a method for the detection and/or typing of Helicobacter pylori (H. pylori ) strains present in a sample including the steps of (i) amplifying the polynucleic acids of target regions of the vacA gene and the cagA gene, with suitable primer pairs, the primers being generally applicable on different H. pylori strains, where the target regions include a conserved region in the case of the cagA alleles and a variable region in the case of the vacA alleles; (ii) hybridizing the polynucleic acids obtained with a set of at least two VDG (virulence determinant gene)-derived probes, and with at least one of the probes hybridizing to a conserved region of a cagA of H. pylori, and with at least one of the probes hybridizing to a variable region of vacA; (iii) detecting the hybrids formed; and (iv) detecting and/or typing H. pylori strains present in a sample from the differential hybridization signals obtained.

Abstract: The present invention relates to a method for the detection and/or typing of Helicobacter pylori (H. pylori) strains present in a sample comprising the steps of: (i) if need be releasing, isolating or concentrating the polynucleic acids in the sample, (ii) amplifying the polynucleic acids of relevant target regions of the vacA gene and possibly other virulence determinant genes (VDG), with suitable primer pairs, said primers being generally applicable on different H. pylori strains, allowing to amplify said relevant target regions of the VDG preferentially in compatible amplification conditions; (iii) hybridizing the polynucleic acids obtained in (i) or (ii) with a set of at least two VDG-derived probes, under appropriate hybridization and wash conditions, and with at least one of said probes hybridizing to a conserved region of a VDG of H. pylori, and with at least one of said probes hybridizing to a variable region of vacA; (iv) detecting the hybrids formed in step (iii), (v) detecting and/or typing H.

Abstract: The invention relates to the use of the GTPase gene family as a target for nucleic acid based assays for the detection and differentiation of prokaryotic organisms. The invention relates to polynucleic acids derived from gene sequences encoding prokaryotic GTPase (=GTP-binding) proteins, as well as their use in the detection and identification of prokaryotic organisms; primers and probes derived from said polynucleic acid sequences, for specific amplification and detection of prokaryotic DNA in a biological sample; as well as methods and kits allowing the detection and identification of at least one micoroorganism, and preferentially several microorganisms simultaneously in a sample. More specifically, the invention relates to new polynucleic acid sequences encoding GTPase proteins from Campylobacter species, primers and probes derived from them, and methods and kits comprising these reagents for the detection and differentiation of species belonging to the genus Campylobacter.