Patents by Inventor Leendert Koenderman

Leendert Koenderman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC CROSSLINKING OF CYTOKINE RECEPTORS
    Publication number: 20220143145
    Abstract: The present invention relates to a compound comprising (1) a first binding moiety that binds to an Interleukin 4 receptor; and (2) a second binding moiety that binds to a cytokine receptor (e.g., an Interleukin 10 receptor, Interleukin 13 receptor, interleukin 27 receptor, interleukin 33 receptor, or transforming growth factor beta 1/2 receptor). Compounds of the disclosure cluster or crosslink the IL4 receptor and a cytokine receptor, and surprisingly, elicit unique responses in the nervous system, including unique signaling and gene expression profiles. The signaling and gene expression profiles generated IL4-cytokine fusion proteins of the disclosure are distinct from those observed in response to the combination of IL4 and the cytokine, and contribute to the superior therapeutic effects over the combination of the component parts.
    Type: Application
    Filed: October 18, 2021
    Publication date: May 12, 2022
    Inventors: Niels EIJKELKAMP, Cornelis Erik HACK, Judith PRADO SANCHEZ, Remco Henri Sebastiaan WESTERINK, Kris Alan REEDQUIST, Leendert KOENDERMAN
  • Activation epitope of Fc?RII (CD32), binding molecules that specifically bind the epitope and means and methods for the detection of the epitope, and uses of said epitope or said binding molecules
    Patent number: 8460883
    Abstract: The present invention provides means and method for detecting an activation epitope on FcyRII (CD32) on Fc? (CD32) expressing cells. The presence of epitope on Fc?RII (CD32) correlates with priming of the cell containing Fc?RII (CD32) expressing said epitope. The invention further provides binding molecules specific for said activation epitope on Fc?RII (CD32), and uses thereof in the detection of activated cells. Further uses are the treatment of individuals suffering from inflammation or at risk of suffering thereof. Also provided, among others, are uses for detecting and/or following an inflammation in an individual.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: June 11, 2013
    Assignee: UMC Utrecht Holding B.V.
    Inventors: Leendert Koenderman, Deonysius Huibert Adrianus Johannes Kanters, Johannes Antonius Maria Raaijmakers, Louis Petrus Hendrikus Leenen
  • ACTIVATION EPITOPE OF FCY RII (CD32), BINDING MOLECULES THAT SPECIFICALLY BIND THE EPITOPE AND MEANS AND METHODS FOR THE DETECTION OF THE EPITOPE, AND USES OF SAID EPITOPE OR SAID BINDING MOLECULES
    Publication number: 20100047250
    Abstract: The present invention provides means and method for detecting an activation epitope on FcyRII (CD32) on Fc? (CD32) expressing cells. The presence of epitope on Fc?RII (CD32) correlates with priming of the cell containing Fc?RII (CD32) expressing said epitope. The invention further provides binding molecules specific for said activation epitope on Fc?RII (CD32), and uses thereof in the detection of activated cells. Further uses are the treatment of individuals suffering from inflammation or at risk of suffering thereof. Also provided, among others, are uses for detecting and/or following an inflammation in an individual.
    Type: Application
    Filed: December 21, 2007
    Publication date: February 25, 2010
    Applicant: UMC Utrecht Holding B.V.
    Inventors: Leendert Koenderman, Deonysius Huibert Adrianus Johannes Kanters, Johannes Antonius Maria Raaijmakers, Louis Petrus Hendrikus Leenen