Abstract: Provided herein are compositions and methods for generating an immunogenic response in humans. Further provided are methods for designing such compositions, e.g., for vaccines.

Abstract: Provided herein are compositions and methods for generating an immunogenic response in humans. Further provided are methods for designing such compositions, e.g., for vaccines.

Abstract: Provided herein are compositions and methods for generating an immunogenic response in humans. Further provided are methods for designing such compositions, e.g., for vaccines.

Abstract: Provided herein are compositions and methods for generating an immunogenic response in humans. Further provided are methods for designing such compositions, e.g., for vaccines.

Abstract: Provided herein are compositions and methods for generating an immunogenic response in humans. Further provided are methods for designing such compositions, e.g., for vaccines.

Abstract: Toothbrush comprising a plurality of multi-action bristles which enable the cleaning between the teeth and on the surfaces of the teeth. Certain of the bristles are longer than others, enabling them to reach into small but deep crevices on the surface of the tooth, and between teeth. Certain of the bristles are harder than others, enabling the effective cleaning of the tooth by removing stubborn debris that would remain were the bristles too soft. The bristles can be provided in spaced arrays, and a single filament attached to the head of the toothbrush at a point intermediate its length can be used to form a longer and a shorter bristle extending orthogonally from the head. Reduction or elimination of bacteria residing on the toothbrush is achieved by incorporating in the bristles or filaments making up the bristles one or more antimicrobial agents, such as nanosilver.