Abstract: The disclosure provides a compound shown in formula (I) and a prodrug thereof, which have a good MDM2 and/or MDMX inhibiting effect and may be used for treating MDM2 and/or MDMX-mediated symptoms and/or diseases such as neoplastic diseases and/or idiopathic pulmonary fibrosis and preparing drugs for such symptoms or diseases. In particular, a compound containing a phosphoric acid (phosphate) structure has higher solubility. As the prodrug, the compound can release an MDM2 and/or MDMX double-target inhibitor compound with high activity in an animal body, which solves the problem that such double-target inhibitors are hardly prepared into drugs.

Abstract: Techniques for mobile user identity and/or SIM-based IoT identity and application identity based security enforcement in service provider networks (e.g., service provider networks for mobile subscribers) are disclosed. In some embodiments, a system/process/computer program product for mobile user identity and/or SIM-based IOT identity and application identity based security enforcement in service provider networks includes monitoring network traffic on a service provider network at a security platform to identify a subscriber identity for a new session; determining an application identifier for user traffic associated with the new session at the security platform; and determining a security policy to apply at the security platform to the new session based on the subscriber identity and the application identifier.

Abstract: Provided is use of a compound shown in formula I, formula I? or formula I?, and tautomers, stereoisomers, or pharmaceutically acceptable salts of the three compounds as METTL3 inhibitors. The compounds have good regulatory and inhibitory effects on METTL3/METTL14 and AML related cell lines. In terms of enzyme and cell activity, they have obvious advantages compared with compounds disclosed in the prior art (under the same Assay, the enzyme and cell activity of the compounds provided by the present disclosure are significantly improved compared with similar compounds in the prior art). Therefore, the compounds provided by the present disclosure can be used for treating symptoms and diseases associated with the methyltransferase activity of METTL3/METTL14. In addition, preparation methods of the compounds provided by the present disclosure are simple and have good application prospects.

Abstract: The present disclosure relates to immunoassays for NF-L performed on liquid samples derived from physiological fluids such as venous blood to detect the presence or absence of a physiological condition by quantifying one or a combination of NF-L determinations at concentrations indicative of the condition.

Abstract: A first firmware source code portion corresponding to an immutable firmware portion of specific firmware to be deployed with embedded devices is identified. A second different firmware source code portion corresponding to a mutable firmware portion of the specific firmware to be deployed with the embedded devices is identified. The first firmware source code portion is used to generate the immutable firmware portion of the specific firmware. The second firmware source code portion is used to generate the mutable firmware portion of the specific firmware. The immutable firmware portion of the specific firmware is caused to be installed in fixed storage drives of an embedded device in the embedded devices. The mutable firmware portion of the specific firmware is caused to be installed in swappable storage drives of the same embedded device.

Abstract: A secure communications and configuration system for digital currency mining systems provides two levels of digital signatures for communications between digital currency mining systems and a central management server where general communications are signed using software generated keys and sensitive communications are signed using an on-board encryption chip. The central management server verifies an initial registration message from a digital currency mining system and send initial configuration data to the digital currency mining system automatically.

Abstract: A local buffer is integrated with a witness generator and a proof generator on a cryptographic processor and is separate from host memory accessed by a host processor operating with the cryptographic processor in a proving computing system. The witness generator: receives, from software program running on the host processor, compiled code of a zero-knowledge-proof (ZKP) program and specific input to the ZKP program; executes the ZKP program by way of executing the compiled code; records specific output generated from the ZKP program with the specific input, intermediate variable values, and the specific input, as a specific witness of executing the ZKP program; stores the specific witness in the local buffer. The proof generator: receives, from the software program running on the host processor, a proving key; accesses the specific witness in the local buffer; generates a specific zero-knowledge proof for executing the ZKP program with the specific input.

Abstract: The present disclosure relates to immunoassays for NF-L, GFAP, UCH L1, and Tau performed on liquid samples derived from physiological fluids such as venous blood to detect the presence or absence of a physiological condition by quantifying one or a combination of NF-L, GFAP, UCH L1, and Tau at concentrations indicative of the condition.

Abstract: A local buffer is integrated with a witness generator and a proof generator on a cryptographic processor and is separate from host memory accessed by a host processor operating with the cryptographic processor in a proving computing system. The witness generator: receives, from software program running on the host processor, compiled code of a zero-knowledge-proof (ZKP) program and specific input to the ZKP program; executes the ZKP program by way of executing the compiled code; records specific output generated from the ZKP program with the specific input, intermediate variable values, and the specific input, as a specific witness of executing the ZKP program; stores the specific witness in the local buffer. The proof generator: receives, from the software program running on the host processor, a proving key; accesses the specific witness in the local buffer; generates a specific zero-knowledge proof for executing the ZKP program with the specific input.

Abstract: The present disclosure relates to digital immunoassays performed on diluted samples obtained from dried blood spots, for example dried capillary blood samples, to detect the presence or absence of a physiological condition by quantifying one or a combination of biomarkers at concentrations indicative of the condition.

Abstract: An asset management method is provided. The asset management method includes establishing a network connection between a cryptomining asset and an asset management server. The asset management method includes generating a digital token, wherein the digital token includes an identifier assigned to the cryptomining asset by a cryptomining asset provider. The asset management method includes transmitting, to the asset management server and via the network connection, the digital token. The asset management method includes receiving, from the asset management server, a message corresponding to the identifier, wherein the message includes a configuration of a cryptomining task. The asset management method includes loading the configuration in the cryptomining asset. Another asset management method and a cryptomining asset are also provided.

Abstract: A first firmware source code portion corresponding to an immutable firmware portion of specific firmware to be deployed with embedded devices is identified. A second different firmware source code portion corresponding to a mutable firmware portion of the specific firmware to be deployed with the embedded devices is identified. The first firmware source code portion is used to generate the immutable firmware portion of the specific firmware. The second firmware source code portion is used to generate the mutable firmware portion of the specific firmware. The immutable firmware portion of the specific firmware is caused to be installed in fixed storage drives of an embedded device in the embedded devices. The mutable firmware portion of the specific firmware is caused to be installed in swappable storage drives of the same embedded device.

Abstract: Techniques for mobile user identity and/or SIM-based IoT identity and application identity based security enforcement in service provider networks (e.g., service provider networks for mobile subscribers) are disclosed. In some embodiments, a system/process/computer program product for mobile user identity and/or SIM-based IOT identity and application identity based security enforcement in service provider networks includes monitoring network traffic on a service provider network at a security platform to identify a subscriber identity for a new session; determining an application identifier for user traffic associated with the new session at the security platform; and determining a security policy to apply at the security platform to the new session based on the subscriber identity and the application identifier.

Abstract: Techniques for reduction and acceleration of a deterministic finite automaton (DFA) are disclosed. In some embodiments, a system, process, and/or computer program product for reduction and acceleration of a DFA includes receiving an input value; performing a reduced deterministic finite automaton lookup using a lookup key, wherein the lookup key comprises a current state and the input value; and determining a next state based on the lookup key.

Abstract: The present application discloses a multi-path resonant circuit and a resonant converter. The multi-path resonant circuit includes at least two parallel N-phase resonant circuits, wherein N is an integer greater than or equal to 3. The at least two parallel N-phase resonant circuits include a first N-phase resonant circuit and a second N-phase resonant circuit. A first resonant inductor in any phase resonant circuit of the first N-phase resonant circuit is coupled with a second resonant inductor in any phase resonant circuit of the second N-phase resonant circuit. In this way, current sharing of the multi-path resonant circuit can be realized through a simpler structure.

Abstract: The present disclosure provides a magnetic component and a power module, relating to the technical field of power electronics; the magnetic component provided by the present disclosure includes: a first heat sink, a magnetic core extending in a transverse direction and a winding structure wound on the magnetic core, the winding structure includes at least a first coil and a second coil arranged adjacently along the transverse direction, a gap is provided between the first coil and the second coil, at least part of the first heat sink is arranged in the gap, the first heat sink is in thermal contact with the first coil, the second coil and the magnetic core.

Abstract: Techniques for mobile user identity and/or SIM-based IoT identity and application identity based security enforcement in service provider networks (e.g., service provider networks for mobile subscribers) are disclosed. In some embodiments, a system/process/computer program product for mobile user identity and/or SIM-based IOT identity and application identity based security enforcement in service provider networks includes monitoring network traffic on a service provider network at a security platform to identify a subscriber identity for a new session; determining an application identifier for user traffic associated with the new session at the security platform; and determining a security policy to apply at the security platform to the new session based on the subscriber identity and the application identifier.

Abstract: A local buffer is integrated with a witness generator and a proof generator on a cryptographic processor and is separate from host memory accessed by a host processor operating with the cryptographic processor in a proving computing system. The witness generator: receives, from software program running on the host processor, compiled code of a zero-knowledge-proof (ZKP) program and specific input to the ZKP program; executes the ZKP program by way of executing the compiled code; records specific output generated from the ZKP program with the specific input, intermediate variable values, and the specific input, as a specific witness of executing the ZKP program; stores the specific witness in the local buffer. The proof generator: receives, from the software program running on the host processor, a proving key; accesses the specific witness in the local buffer; generates a specific zero-knowledge proof for executing the ZKP program with the specific input.

Abstract: A first firmware source code portion corresponding to an immutable firmware portion of specific firmware to be deployed with embedded devices is identified. A second different firmware source code portion corresponding to a mutable firmware portion of the specific firmware to be deployed with the embedded devices is identified. The first firmware source code portion is used to generate the immutable firmware portion of the specific firmware. The second firmware source code portion is used to generate the mutable firmware portion of the specific firmware. The immutable firmware portion of the specific firmware is caused to be installed in fixed storage drives of an embedded device in the embedded devices. The mutable firmware portion of the specific firmware is caused to be installed in swappable storage drives of the same embedded device.

Abstract: The present disclosure provides a magnetic component and a power module, relating to the technical field of power electronics; the magnetic component provided by the present disclosure includes: a first heat sink, a magnetic core extending in a transverse direction and a winding structure wound on the magnetic core, the winding structure includes at least a first coil and a second coil arranged adjacently along the transverse direction, a gap is provided between the first coil and the second coil, at least part of the first heat sink is arranged in the gap, the first heat sink is in thermal contact with the first coil, the second coil and the magnetic core.