Abstract: In accordance with the invention, a novel gene translocation, (5q32, 6q22), in human non-small cell lung carcinoma (NSCLC) that results in a fusion proteins combining part of CD74 with Proto-oncogene Tyrosine Protein Kinase ROS Precursor (ROS) kinase has now been identified. The CD74-ROS fusion protein is anticipated to drive the proliferation and survival of a subgroup of NSCLC tumors. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ROS kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides.

Abstract: A power inverter with liquid cooled busbars includes multiple AC power outlets. The power inverter also includes a busbar having a busbar arm connected to one of the AC power outlets, and a busbar leg having a first end connected to the busbar arm. The busbar leg is at least partially situated in a cooling channel of the power inverter, which may be a built-in cooling channel or a detachable cooling channel. A second end of the busbar leg extends beyond the cooling channel and is exposed for electrical connection.

Abstract: A three-dimensional shape estimation method includes acquiring object information of a target object captured by an aerial vehicle while flying at a plurality of flight heights and estimating a three-dimensional shape of the target object based on the object information.

Abstract: A pressure sensor may measure gas or liquid pressure. A chamber may have an inlet that receives the gas or liquid. A flexible diaphragm may be within the chamber that has a surface exposed to the gas or liquid after it flows through the inlet. A pressure sensor system may sense changes in the flexible diaphragm caused by changes in the pressure of the gas or liquid. A pressure-insensitive sensor system may sense changes in the flexible diaphragm that are not caused by changes in the pressure of the gas or liquid. The pressure-insensitive sensor system may be insensitive to changes in the flexible diaphragm caused by changes in the pressure of the gas or liquid.

Abstract: The disclosed computer-implemented method for enforcing access-control policies in an arbitrary physical space may include (i) identifying a collection of devices that are located within a predetermined physical space, (ii) determining the physical location of each device in the collection of devices, (iii) establishing, based on the collection of devices, (a) a list of controlled devices that are subject to an access-control policy and (b) a list of monitoring devices that are capable of monitoring user activity within a physical proximity, (iv) matching each controlled device with at least one monitoring device that is capable of monitoring user activity within physical proximity to the controlled device, and (v) monitoring, for each controlled device and by each monitoring device matched to the controlled device, user activity within proximity to the controlled device. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: To generate an optimal flight direction of an unmanned aerial vehicle and to facilitate the operation by a user. A flight route display method comprises the steps of: acquiring a flight range of an unmanned aerial vehicle and environment information related to the unmanned aerial vehicle; calculating, within the flight range, based on a flight direction index relative to a flight route of the unmanned aerial vehicle, an optimal flight route; and displaying the optimal flight route within the flight range of the unmanned aerial vehicle.

Abstract: A computer-implemented method for providing security in smart buildings may include (1) detecting the presence of a user in a smart building, (2) determining that the user is unauthorized to access at least one resource in a smart building network within the smart building, (3) in response to determining that the user is unauthorized to access the resource in the smart building network, selecting an authentication policy that provides heightened security within the smart building network, and (4) increasing security within the smart building network to reflect the presence of the user by implementing the authentication policy within the smart building network. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The content of each specific image file in a user's backup set (or other type of file set on an endpoint) is analyzed, for example during a backup of the endpoint. Each analyzed image file is categorized based on the results of analyzing its content. The analysis can be in the form identifying one or more objects graphically represented in given image files, and the categorization of image files can be based on these identified graphically represented object(s). Subsequently (for example during a subsequent backup of the endpoint), modifications made to specific ones of the image files in the file set are detected. In response to a quantification of the detected modifications exceeding a specific threshold level, it is adjudicated that a file corruption event has occurred on the endpoint, such as a cryptographic ransomware attack. In response to the adjudication, one or more security actions are taken.

Abstract: A computer-implemented method for preventing addictive application usage may include (i) identifying a user of a software application, (ii) monitoring the user's habits in relation to accessing the software application, (iii) determining that the user's habits indicate potentially addictive behavior relative to a baseline behavior in relation to accessing the software application, and (iv) automatically executing an application control action in response to determining that the user's habits indicate potentially addictive behavior. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A three-dimensional shape estimation method includes generating a set of three-dimensional shape data for a flight range of a movable object based on a plurality of first images captured by a movable object, detecting a loss area based on the set of three-dimensional shape data for the flight range, generating a flight route for imaging the loss area, acquiring a plurality of second images that are captured in a horizontal direction toward the loss area with imaging ranges partially overlapped while the movable object moves along the flight route, and generating three-dimensional shape data for the loss area based on the plurality of second images.

Abstract: A computer-implemented method for efficient backup deduplication may include (1) identifying a file to be divided into chunks for deduplication, (2) requesting, from a server, a chunk size to use when dividing the file for deduplication by submitting at least one attribute of the file to the server, the server selecting the chunk size based at least in part on a projected chunk reuse rate when the file is deduplicated according to the chunk size, (3) receiving from the server, in response to requesting the chunk size, the chunk size to use when dividing the file for deduplication, and (4) dividing the file for deduplication into a plurality of chunks according to the chunk size. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A computer-implemented method for enforcing access-control policies may include (i) identifying streaming content that is being transmitted from a media server to a media playback system, (ii) determining that a supervised user is within exposure range of the media playback system and could be exposed to the streaming content, (iii) receiving a sample of the content from a sampling system that is remote from the media playback system, (iv) identifying an access-control policy that defines a content-access restriction for the supervised user, (v) determining, based on an analysis of the sample of the content, that the access-control policy applies to the content, and (vi) in response to determining that the access-control policy applies to the content, enforcing the access-control policy by applying the content-access restriction to the streaming content. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A flight path generation method includes determining a plurality of photographing positions for a flight vehicle to photograph a subject based on a flight range of the flight vehicle and photographing position intervals, and generating a flight path of the flight vehicle that passes through the photographing positions.

Abstract: The disclosed computer-implemented method for enforcing access-control policies may include (i) determining that a user is attempting to access a controlled device that is subject to an access-control policy, (ii) locating at least one additional device that is in physical proximity to the controlled device, (iii) acquiring context information from the additional device that provides information about the identity of the user, (iv) establishing the identity of the user based on the context information acquired from the additional device, and (v) enforcing the access-control policy based on the identity of the user. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A computer-implemented method for generating tripwire files may include (1) generating an initial tripwire file according to an initial tripwire generation calculation, the initial tripwire file configured such that modification of the initial tripwire file triggers investigation of a security breach, (2) generating a subsequent tripwire file according to a subsequent tripwire generation calculation, the subsequent tripwire generation calculation differing from the initial tripwire generation calculation along at least one dimension, (3) receiving automated feedback that indicates whether at least one of the initial tripwire file and the subsequent tripwire file failed to enable detection of a security threat, and (4) adjusting automatic generation of a third tripwire file based on the automated feedback indicating whether at least one of the initial tripwire file and the subsequent tripwire file failed to detect the security threat.

Abstract: An apparatus (100, 200, 300) and a method for measuring residual torsions of an elongated structure (202) such as a steel cord use a pivot head (102). The pivot head (102) comprises a wheel (104) adapted to guide an elongated structure (202). The wheel (104) is mounted in the pivot head (102) to transmit torques exercised by the elongated structure (202) on the wheel (104) to the pivot head (102). The pivot head (102) is mounted along a pivotal axis (110). This pivotal axis (110) lies in a plane of the wheel (104) and comprises the center of the wheel (104). Sensors (116, 206) measure the torque on the pivot head (102). The pivotal movement of the pivot head (102) around the pivotal axis (110) is limited to an angle range of ±5°, preferably ±3° in order to reach an improved accuracy of the torque measurement.

Abstract: Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have been identified herein in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFC). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides.

Abstract: The invention provides the identification of the presence of polypeptides with ROS kinase activity in mammalian lung cancer. In some embodiments, the polypeptide with ROS kinase activity is the result of a fusion between a ROS-encoding polynucleotide and a polynucleotide encoding a second (non-ROS) polypeptide. Three different fusion partners of ROS are described, namely proteins encoded by the FIG gene, the SLC34A2 gene, and the CD74 gene. The invention enables new methods for determining the presence of a polypeptide with ROS kinase activity in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer (e.g.

Abstract: The disclosed computer-implemented method for detecting and addressing suspicious file restore activities may include (i) detecting a restore activity during which files are restored to a client device from a previously stored backup of the files, (ii) determining that a total number of the files restored during the restore activity exceeds a threshold number, and (iii) performing, based on the total number of the files exceeding the threshold number, a security action to protect the client device from a malicious threat associated with the restore activity. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant polypeptides, probes for detecting it, isolated mutant polypeptides, and reagents for detecting the fusion and truncated polypeptides.