Abstract: The present invention provides methods, compositions, systems, and kits comprising nano-satellite complexes and/or serum albumin carrier complexes, which are used for modulating antigen-specific immune response (e.g., enhancing anti-tumor immunity). In certain embodiments, the nano-satellite complexes comprise: a) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; b) at least one satellite particle attached to, or absorbed to, the biocompatible coating; and c) an antigenic component conjugated to, or absorbed to, the at least one satellite particle component. In certain embodiments, the complexes further comprise: d) a type I interferon agonist agent. In some embodiments, the serum albumin complexes comprise: a) at least part of a serum albumin protein, b) an antigenic component conjugated to the carrier protein, and c) a type I interferon agonist agent.

Abstract: Embodiments of this application disclose a trans-impedance amplifier and a trans-impedance amplifier control method that are used in the field of circuit technologies. A trans-impedance amplifier TIA includes an inverting amplification circuit and a voltage clamping circuit. The inverting amplification circuit is connected in parallel to the voltage clamping circuit. The inverting amplification circuit includes a first PMOS transistor and a first NMOS transistor that have a common gate. A source of the first PMOS transistor is connected to a drain of the first NMOS transistor. The voltage clamping circuit includes a second PMOS transistor and a second NMOS transistor that have a common gate. Gates of the two transistors are connected to an input end of the TIA. A source of the second NMOS transistor and a drain of the second PMOS transistor are connected to an output end of the TIA.

Abstract: A battery cover includes a top cover assembly and an insulating support. The top cover assembly can be fixedly connected with a case to form an accommodation space for accommodating a core, and the top cover assembly can be welded with a tab on the core. The insulating support can be accommodated in the accommodation space. The insulating support and the top cover assembly form an accommodation cavity for accommodating the tab, and the insulating support is provided with a notch for the tab to pass through.

Abstract: The invention belongs to the technical field of metal ceramics, in particular to a metal ceramic and a preparation method thereof. The hard phase is formed by at least four kinds of crystal grains with different compositions and shapes; and in the scanning electron microscope photograph of the metal ceramic, it can be observed the first hard phase comprising black titanium nitrocarbide, a thin ring and a thick ring wherein the core phase is pure black; the second hard phase in the form of a dark gray core-ring structure particles; the third hard phase in the form of a high-brightness white core-gray ring; and the fourth hard phase in the form of a homogenous gray phase and off-white core-gray ring structure particles. In addition, a white binder phase can also be observed, and the binder phase is at least one of cobalt and nickel.

Abstract: The present disclosure discloses a water-replenishing fishway with an adaptively-adjusted floating dock, comprising: a fishway body, wherein the bottom of the fishway body is rotationally connected with a floating dock structure, an auxiliary swimming structure is arranged inside the fishway body, and an adjusting structure used to adjust the auxiliary swimming board of the auxiliary swimming structure is arranged on said floating dock structure. The present disclosure can adaptively adjust the angle of the fishway body and auxiliary swimming board and effectively assist the fish's migration.

Abstract: A composition containing recombinant collagen with repairing and soothing effects, eye cream containing the composition and preparation method thereof are provided. The composition contains the following raw materials in parts by weight: 1 to 10 parts of recombinant collagen, 1 to 10 parts of sodium hyaluronate, 1 to 5 parts of bifida ferment lysate, 1 to 15 parts of glucosylglycerol, 1 to 10 parts of bisabolol, 1 to 15 parts eight-treasure essence stock solution, and 1 to 15 parts of pink red plum rechecking essence. The composition features with good skin permeability, contributing to its significant effects on repairing skin barriers and relieving skin inflammation, as well as its advantages of low irritation and high safety. Thus, the composition is suitable for people with damaged eye skin and has good market application prospects.

Abstract: A modular blade connection structure includes a first module, a second module and a structural adhesive module. The first module is provided on an end face thereof with a bonding flange extending into the second module; a gap between the butting surfaces of the first module and the second module is injected with a structural adhesive, which is extruded and cured to form a structural adhesive module; and the thickness of the first module at the starting end of the bonding flange extends towards the inner surface to form a first reinforcement, and the structural adhesive module extends inside the second module in a direction away from the bonding flange to form a second reinforcement. The present disclosure facilitates the control the bonding quality of the double-sided overlapping of the modular blade by means of the bonding flange and the improvement of the fatigue resistance at the assembling position.

Abstract: An audio signal processing method, an audio signal processing apparatus, a computer device and a storage medium are provided. The audio signal processing method includes acquiring, by using the voice registration module based on a first audio signal, a first hidden state corresponding to a voice registration module is acquired, and, extracting, based on the first hidden state, a target audio signal from a second audio signal.

Abstract: The present disclosure provides a particle size statistical method of granular minerals of shale, comprising: collecting shale samples; cutting the collected samples into the size of 1 cm×1 cm×1 cm; performing argon ion polishing; magnifying the samples by the field emission scanning electron microscopy, collecting 500-1000 images; using Adobe Photoshop to seamlessly splice the collected images; using ImageJ in combination with EDS energy spectrum to determine types of mineral particles, performing background subtraction, and setting a reasonable grayscale threshold to classify the particle minerals; performing binary processing on the images of selected mineral particle types; identifying edges of granular minerals, and using a Analyze Particles command to statistically analyze and measure particle sizes, and drawing a particle size distribution histogram.

Abstract: An embodiment disclosed herein includes a method of dicing a wafer comprising a plurality of integrated circuits. In an embodiment, the method comprises forming a mask above the semiconductor wafer, and patterning the mask and the semiconductor wafer with a first laser process. The method may further comprise patterning the mask and the semiconductor wafer with a second laser process, where the second laser process is different than the first laser process. In an embodiment, the method may further comprise etching the semiconductor wafer with a plasma etching process to singulate the integrated circuits.

Abstract: A position detection method may include obtaining voice signals during a voice call by at least two voice collecting devices; obtaining position energy information of the voice signals; and identifying a position of the terminal device relative to a user during the voice call, from predefined positions based on the position energy information.

Abstract: Disclosed in an interface circuit, in which: a current input circuit receives an input current signal of a signal input terminal, an input voltage detection circuit compares an input voltage signal of the signal input terminal with a reference voltage, and provides a detection signal to the current input circuit according to the comparison result, a phase-inversion output circuit is connected with the current input circuit at the first node, and generates a voltage conversion signal according to a voltage potential of the first node, and a buffer circuit performs signal shaping on the voltage conversion signal to obtain an output signal. The current input circuit pulls up the voltage potential of the first node when the detection signal indicates that the input voltage signal is greater than the reference voltage and the input current signal is greater than a reference current.

Abstract: Disclosed is a controller and a control method of a thermoelectric cooler-heater device. The controller includes a switching power supply coupled to the thermoelectric cooler-heater device to provide a first driving current; and a constant-current constant-voltage power supply coupled to the thermoelectric cooler-heater device to provide a second driving current. According to a temperature detection signal, one of the switching power supply and the constant-current constant-voltage power supply operates, the first driving current is a continuous driving current flowing from an anode end to a cathode end of the thermoelectric cooler-heater device, the second driving current is a pulse driving current flowing from the cathode end to the anode end.

Abstract: A pressure-adjustable auxiliary control system for high-pressure gas sealing detection includes: a high-pressure chamber environment monitoring unit configured to construct high-pressure test gas sealing environment and to test sealing performance of a sealing member; a first gas pipeline divided into two branches, of which one branch is connected to the high-pressure chamber environment monitoring unit as a first gas replacement path; a second gas pipeline which is connected to a test gas pressurization path together with the other branch of the first gas pipeline, where a first booster pump processing unit and a second booster pump processing unit are sequentially arranged in the test gas pressurization path for pressurizing the test gas, and are connected to the high-pressure chamber environment monitoring unit; a system air control module configured for control of respective air control valves; and a booster pump air control module and a driving air source preprocessing unit.

Abstract: Systems and methods for automated imaging and evaluation of image based features are disclosed herein. Method for automated imaging and evaluation of image based features can include receiving time-lapse images of at least one human embryo contained in a multi-well culture dish that can have a plurality of micro-wells. Image based features can be automatically generated from the time-lapse images of the human embryo. The image based features, which can include a cavitation feature, can be inputted into a classifier. The classifier can automatically and directly generate a viability prediction with the classifier from the image-based features.

Abstract: Provided are compounds and compositions for prevention and/or elimination of Zika virus infection. Also provided are methods for preventing and treating a subject in need of prevention or treatment of Zika virus.

Abstract: A pressure-adjustable auxiliary control system for high-pressure gas sealing detection includes: a high-pressure chamber environment monitoring unit configured to construct high-pressure test gas sealing environment and to test sealing performance of a sealing member; a first gas pipeline divided into two branches, of which one branch is connected to the high-pressure chamber environment monitoring unit as a first gas replacement path; a second gas pipeline which is connected to a test gas pressurization path together with the other branch of the first gas pipeline, where a first booster pump processing unit and a second booster pump processing unit are sequentially arranged in the test gas pressurization path for pressurizing the test gas, and are connected to the high-pressure chamber environment monitoring unit; a system air control module configured for control of respective air control valves; and a booster pump air control module and a driving air source preprocessing unit.

Abstract: The present application relates a composite multi-epitope expression cassette, a recombinant virus composed thereof and application thereof, and in particular to a chimeric recombinant Newcastle disease virus inserted with an IBV epitope cassette and a vaccine prepared by using the virus. The expression cassette comprises: (a) T cell epitopes derived from S1 proteins of avian infectious bronchitis virus Holte strain and avian infectious bronchitis virus QX-like strain; and (b) B cell epitopes derived from S1 protein of avian infectious bronchitis virus Australian T strain. In the present application, the multi-epitope chimeric ST/B gene of avian infectious bronchitis virus is inserted into the backbone of LaSota strain, so that the LaSota strain can express S1-T/B protein. Thus, the purpose of preventing both ND and IB diseases is achieved. In addition, the T cell epitopes and B cell epitopes act synergistically to produce an earlier and more comprehensive immune response against virus.

Abstract: The present application relates a composite multi-epitope expression cassette, a recombinant virus composed thereof and application thereof, and in particular to a chimeric recombinant Newcastle disease virus inserted with an IBV epitope cassette and a vaccine prepared by using the virus. The expression cassette comprises: (a) T cell epitopes derived from S1 proteins of avian infectious bronchitis virus Holte strain and avian infectious bronchitis virus QX-like strain; and (b) B cell epitopes derived from S1 protein of avian infectious bronchitis virus Australian T strain. In the present application, the multi-epitope chimeric ST/B gene of avian infectious bronchitis virus is inserted into the backbone of LaSota strain, so that the LaSota strain can express S1-T/B protein. Thus, the purpose of preventing both ND and IB diseases is achieved. In addition, the T cell epitopes and B cell epitopes act synergistically to produce an earlier and more comprehensive immune response against virus.

Abstract: The invention belongs to the field of medicine, involving new uses of Paliurus ramosissimus (Lour.) Poir. and its extract, in particular the use of Paliurus ramosissimus (Lour.) Poir. and its extract in preparation of drugs with anti-fibrotic, anti-fungal, and anti-tumor activities, for the treatment of oral and digestive tract inflammation or (and) ulcer-related diseases, or with bi-directional immunomodulatory effects.