Abstract: Antibodies that bind to both CEACAM5 and CEACAM6 and antigen-binding fragments thereof, as well as uses thereof, nucleic acids encoding the antibodies and antigen-binding fragments, vectors comprising the nucleic acids, and host cell comprising the nucleic acids or the vectors. The pharmaceutical compositions and conjugates comprising the antibodies, and therapeutic methods by administering the antibodies.

Abstract: A crystal form and salt form of a five- and six-membered compound, a preparation method therefor, a pharmaceutical composition thereof, and a use thereof are disclosed. Specifically, a crystal form and salt form of a five-membered-fused six-membered compound as shown in formula I, a preparation method therefor, a pharmaceutical composition thereof, and a use thereof are disclosed. The crystal form and salt form of the compound have an inhibitory effect on FLT3 and/or IRAK4. The crystal form has a high single melt point, is thermodynamically stable, and has high crystallinity. The crystal form represents good physical and chemical stability under strong illumination, high temperature and high humidity conditions, and the crystal form has weak hygroscopicity.

Abstract: Provided are IL-2 variants, polypeptide complexes comprising the IL-2 variants and compositions comprising the polypeptide complexes, the methods of producing the same and the uses thereof. The IL-2 variants and polypeptide complexes of the disclosure can be used as a potent agent for the treatment of cancers, autoimmune and inflammatory diseases.

Abstract: Valve clip having locking mechanism includes first clamping arm, second clamping arm, linking member, push-pull device and locking device. The locking device fitted with the linking member and includes locking head and self-locking rod. The linking member hinged to each of the first clamping arm and the second clamping arm which include a long arm whose end is hinged to the push-pull device and a short arm whose end is provided with a locking portion. When the push-pull device operated to enlarge opening angle between the long arms of the first clamping arm and the second clamping arm in an open state, the locking portions of the first clamping arm and the second clamping arm are in a staggered fit state; and when to narrow the opening angle in a closed state, the locking device moved to cause the locking head to be fitted and locked to the locking portions.

Abstract: A display panel, a display device and a manufacturing method of a display panel are provided. The display panel includes a backplane and a plurality of first electrodes. The backplane includes a first main surface and a second main surface opposite to each other, and a plurality of side surfaces connecting the first main surface and the second main surface. At least one side surface in the plurality of side surfaces is a selected side surface. Two adjacent side surfaces are provided with a transition side surface therebetween, and are connected through the transition side surface. The plurality of first electrodes are disposed on the first main surface. The plurality of first electrodes are adjacent to the selected side surface.

Abstract: A catalyst system for a carbonylation reaction and a method for a carbonylation reaction. The catalyst system includes (a) a group VIII metal or a compound of the group VIII metal; (b) a bidentate phosphine ligand; and (c) an acidic additive. The component (b) is formula (I): R1>P-A-Ar—B-P<R2 (I), wherein P represents a trivalent phosphorus atom; Ar represents an aromatic group, A and B each represent an alkylene group, and A and B are located at adjacent positions on Ar; R1 and R2, each together with P atoms linked thereto, form a phosphorus monocyclic group of which the ring contains at least three carbon atoms; the monocyclic group includes an alicyclic group having a substituent or no substituent, a lactone group, a lactam group, a cyclic ketone group, an N-containing heterocyclic group, and an O-containing heterocyclic group, and the substituent is linked to the monocyclic group.

Abstract: Disclosed are to bifunctional compounds that target PRMT5 for degradation, compositions, and methods for treating diseases or conditions mediated by aberrant arginine methyltransferase 5 (PRMT5) activity.

Abstract: A whole-process automatic loading-and-unloading and logistics system is disclosed. The system includes an outer yarn preparation area, an inner yarn preparation area, a weaving area and an in-air conveying rail; the outer yarn preparation area is configured to have a carrier assembly, which delivers an outer yarn winding package to an outer yarn branch rail of a twisting machine in a twisting area via the out yarn main rail of the in-air conveying rail; in the inner yarn preparation area, the carrier assembly delivers an inner yarn winding package to an inner yarn branch rail of the twisting machine in the twisting area via the inner yarn main rail of the in-air conveying rail; in the twisting area, the carrier assembly delivers a yarn product to a yarn product donning rail in the weaving area via the yarn product main rail of the in-air conveying rail.

Abstract: The present disclosure provides a wind turbine, a converter, and a low-voltage ride-through detection method and device. The low-voltage ride-through detection method includes: determining an adjustment value of a preset parameter of a power grid on the basis of a power grid voltage, wherein the preset parameter includes at least one of a current, a current frequency and a power factor angle; adjusting the preset parameter of the power grid on the basis of the adjustment value; and detecting, on the basis of a power grid voltage after the preset parameter of the power grid is adjusted, whether the power grid meets a low-voltage ride-through condition. Therefore, a power grid fault of the wind turbine in a weak grid can be accurately identified, so as to enter a low-voltage ride-through state, thereby avoiding system instability in the process of a power grid fault ride-through in the weak grid.

Abstract: The present disclosure generally relates to conjugates, compounds, and compositions comprising a PTK7 antibody, and to methods of using the conjugates for treating cancers and tumors.

Abstract: An antenna includes a dielectric substrate having a first surface and a second surface opposite to each other, a first conductive plate arranged at the first surface, a second conductive plate arranged at the second surface, and a plurality of metal members sequentially arranged adjacently one after another at the dielectric substrate. A distance between two adjacent metal members among the plurality of metal members is greater than a preset distance, and a projection of an overall shape of the plurality of metal members on the dielectric substrate has an opening.

Abstract: A document authenticity identification method is provided. A dynamic anti-counterfeiting point is detected in each document image of a subset of a plurality of document images. A static anti-counterfeiting point is detected in a document image of the plurality of document images. A static anti-counterfeiting point feature is generated based on image feature information of the static anti-counterfeiting point that is extracted from the document image. A dynamic anti-counterfeiting point feature is generated based on image feature information of the dynamic anti-counterfeiting point and variation feature information of the dynamic anti-counterfeiting point. A first authenticity result corresponding to the static anti-counterfeiting point is determined based on the static anti-counterfeiting point feature. A second authenticity result corresponding to the dynamic anti-counterfeiting point is determined based on the dynamic anti-counterfeiting point feature.

Abstract: A method and apparatus for preparing methyl methacrylate (MMA) are provided. The method includes an aldol condensation reaction, a first distillation, a second distillation, a third distillation, a phase splitting, and a fourth distillation. Through the control of the process, the aldol condensation reaction can be performed when methyl propionate is used as the ninth material stream and formalin solution is used as the fifteenth stream material, MMA is obtained as the final product from the third material stream, and the waste with low content of residual formaldehyde is recovered from the eighth material stream.

Abstract: Disclosed in the present invention are a five-membered ring-fused six-membered ring compound, a preparation method therefor, and a pharmaceutical composition and the use thereof. Provided in the present invention is a compound as represented by formula (I), or a pharmaceutically acceptable salt or an isotope compound thereof. The compound of the present invention has an inhibition and/or degradation effect on IRAK4.

Abstract: Method and apparatus for text processing based on large model, and method and apparatus for large model compression are disclosed, which relate to the technical field of artificial intelligence field such as deep learning, large model, and natural language processing.

Abstract: A device management method and a network device are disclosed. The method includes: when the first device is a master device, the network support module of the first device receiving a discovery request sent by the network support module of a second device, wherein the discovery request includes target device information; the network support module of the first device sending a management notification to the network support module of the second device, and sending a join event to the network service module of the first device; the network service module of the first device sending first configuration information matching the target device information to the network support module of the first device; the network support module of the first device sending the first configuration information to the network service module of the second device; the network service module of the second device performing configuration by using the first configuration information.

Abstract: Disclosed in the present invention are a five-membered ring-fused six-membered ring compound, a preparation method therefor, and a pharmaceutical composition and the use thereof. Provided in the present invention is a compound as represented by formula (I), or a pharmaceutically acceptable salt or an isotope compound thereof. The compound of the present invention has an inhibition and/or degradation effect on IRAK4.

Abstract: The invention provides a compound represented by structural formula (I) or formula (II), or a pharmaceutically acceptable salt or a stereoisomer thereof useful for treating diseases (such as cancer) that are treatable by inhibiting HPK1 activity.

Abstract: Provided herein is a compound represented by structural formula (I-0) or formula (II): or a pharmaceutically acceptable salt or a stereoisomer thereof useful for treating diseases (such as cancer) that are treatable by inhibiting HPK1 activity.

Abstract: A multiplex KASP marker primer set for a set of wheat plant height major genes, consisting of a pre-primer having a nucleotide sequence as shown in SEQ ID NO. 10, a post-primer having a nucleotide sequence as shown in SEQ ID NO. 11, and a universal primer having a nucleotide sequence as shown in SEQ ID NO. 9. The multiplex KASP marker primer set achieves the simultaneous detection of the Rht-B1 and Rht-D1 genes.