Abstract: Disclosed are to bifunctional compounds that target PRMT5 for degradation, compositions, and methods for treating diseases or conditions mediated by aberrant arginine methyltransferase 5 (PRMT5) activity.

Abstract: A whole-process automatic loading-and-unloading and logistics system is disclosed. The system includes an outer yarn preparation area, an inner yarn preparation area, a weaving area and an in-air conveying rail; the outer yarn preparation area is configured to have a carrier assembly, which delivers an outer yarn winding package to an outer yarn branch rail of a twisting machine in a twisting area via the out yarn main rail of the in-air conveying rail; in the inner yarn preparation area, the carrier assembly delivers an inner yarn winding package to an inner yarn branch rail of the twisting machine in the twisting area via the inner yarn main rail of the in-air conveying rail; in the twisting area, the carrier assembly delivers a yarn product to a yarn product donning rail in the weaving area via the yarn product main rail of the in-air conveying rail.

Abstract: The present disclosure provides a wind turbine, a converter, and a low-voltage ride-through detection method and device. The low-voltage ride-through detection method includes: determining an adjustment value of a preset parameter of a power grid on the basis of a power grid voltage, wherein the preset parameter includes at least one of a current, a current frequency and a power factor angle; adjusting the preset parameter of the power grid on the basis of the adjustment value; and detecting, on the basis of a power grid voltage after the preset parameter of the power grid is adjusted, whether the power grid meets a low-voltage ride-through condition. Therefore, a power grid fault of the wind turbine in a weak grid can be accurately identified, so as to enter a low-voltage ride-through state, thereby avoiding system instability in the process of a power grid fault ride-through in the weak grid.

Abstract: The present disclosure generally relates to conjugates, compounds, and compositions comprising a PTK7 antibody, and to methods of using the conjugates for treating cancers and tumors.

Abstract: An antenna includes a dielectric substrate having a first surface and a second surface opposite to each other, a first conductive plate arranged at the first surface, a second conductive plate arranged at the second surface, and a plurality of metal members sequentially arranged adjacently one after another at the dielectric substrate. A distance between two adjacent metal members among the plurality of metal members is greater than a preset distance, and a projection of an overall shape of the plurality of metal members on the dielectric substrate has an opening.

Abstract: A document authenticity identification method is provided. A dynamic anti-counterfeiting point is detected in each document image of a subset of a plurality of document images. A static anti-counterfeiting point is detected in a document image of the plurality of document images. A static anti-counterfeiting point feature is generated based on image feature information of the static anti-counterfeiting point that is extracted from the document image. A dynamic anti-counterfeiting point feature is generated based on image feature information of the dynamic anti-counterfeiting point and variation feature information of the dynamic anti-counterfeiting point. A first authenticity result corresponding to the static anti-counterfeiting point is determined based on the static anti-counterfeiting point feature. A second authenticity result corresponding to the dynamic anti-counterfeiting point is determined based on the dynamic anti-counterfeiting point feature.

Abstract: A method and apparatus for preparing methyl methacrylate (MMA) are provided. The method includes an aldol condensation reaction, a first distillation, a second distillation, a third distillation, a phase splitting, and a fourth distillation. Through the control of the process, the aldol condensation reaction can be performed when methyl propionate is used as the ninth material stream and formalin solution is used as the fifteenth stream material, MMA is obtained as the final product from the third material stream, and the waste with low content of residual formaldehyde is recovered from the eighth material stream.

Abstract: Disclosed in the present invention are a five-membered ring-fused six-membered ring compound, a preparation method therefor, and a pharmaceutical composition and the use thereof. Provided in the present invention is a compound as represented by formula (I), or a pharmaceutically acceptable salt or an isotope compound thereof. The compound of the present invention has an inhibition and/or degradation effect on IRAK4.

Abstract: Method and apparatus for text processing based on large model, and method and apparatus for large model compression are disclosed, which relate to the technical field of artificial intelligence field such as deep learning, large model, and natural language processing.

Abstract: A device management method and a network device are disclosed. The method includes: when the first device is a master device, the network support module of the first device receiving a discovery request sent by the network support module of a second device, wherein the discovery request includes target device information; the network support module of the first device sending a management notification to the network support module of the second device, and sending a join event to the network service module of the first device; the network service module of the first device sending first configuration information matching the target device information to the network support module of the first device; the network support module of the first device sending the first configuration information to the network service module of the second device; the network service module of the second device performing configuration by using the first configuration information.

Abstract: Disclosed in the present invention are a five-membered ring-fused six-membered ring compound, a preparation method therefor, and a pharmaceutical composition and the use thereof. Provided in the present invention is a compound as represented by formula (I), or a pharmaceutically acceptable salt or an isotope compound thereof. The compound of the present invention has an inhibition and/or degradation effect on IRAK4.

Abstract: The invention provides a compound represented by structural formula (I) or formula (II), or a pharmaceutically acceptable salt or a stereoisomer thereof useful for treating diseases (such as cancer) that are treatable by inhibiting HPK1 activity.

Abstract: Provided herein is a compound represented by structural formula (I-0) or formula (II): or a pharmaceutically acceptable salt or a stereoisomer thereof useful for treating diseases (such as cancer) that are treatable by inhibiting HPK1 activity.

Abstract: A multiplex KASP marker primer set for a set of wheat plant height major genes, consisting of a pre-primer having a nucleotide sequence as shown in SEQ ID NO. 10, a post-primer having a nucleotide sequence as shown in SEQ ID NO. 11, and a universal primer having a nucleotide sequence as shown in SEQ ID NO. 9. The multiplex KASP marker primer set achieves the simultaneous detection of the Rht-B1 and Rht-D1 genes.

Abstract: Disclosed are a 3D printing device, and a method for preparing a 3D printed structure. The device comprises a curing system (1), and a curing pattern player (6), a flat curing surface (2) with dewettability, and a receiving base (4) capable of moving upwards and away from the flat curing surface, with same being successively arranged above the curing system (1), wherein a curing medium provided by the curing system (1) passes through the curing pattern, so that ink between the flat curing surface (2) and the receiving base (4) is cured.

Abstract: A processing device maintains locking data including a first portion indicating whether a write operation is updating a data item or awaiting to update the data item, and a second portion indicating a number of read operations accessing the data item. A first read operation to the read the data item is received. a first locking condition is determined to be satisfied using the locking data, representing that no write operations are updating the data item or awaiting to update the data item. Responsive to the determination the first locking condition is satisfied, the second portion of the locking data is atomically incremented to reflect the number of read operations reading the data, and the first read operation to read the data is executed.

Abstract: A coolant supply assembly includes an upper housing including a pre-filter mounting portion, a desiccant mounting portion, a pump mounting portion, and a main filter mounting portion on a top surface of the upper housing, the upper housing further including a flange portion at a first side surface of the upper housing and a coolant outlet at a second side surface opposite to the first side surface. The coolant supply assembly further includes a lower housing, the upper housing being mounted to the lower housing to define a coolant chamber, a pre-filter device mounted to the pre-filter mounting portion, a desiccant unit mounted to the desiccant mounting portion, a pump mounted to the pump mounting portion, a heat exchanger mounted to the flange portion, and a main filter device mounted to the main filter mounting portion.

Abstract: A battery pack protection system and a vehicle are provided. The battery pack protection system includes a battery pack and a protective plate. The battery pack includes a tray. The tray includes a frame and a bottom plate. Battery modules are arranged on the bottom plate. The protective plate is arranged parallel to the bottom plate, and the protective plate is close to a side of the bottom plate. At least one sensor is arranged on the protective plate. The protective plate is detachably connected to the frame.

Abstract: A crystal form and salt form of a five- and six-membered compound, a preparation method therefor, a pharmaceutical composition thereof, and a use thereof are disclosed. Specifically, a crystal form and salt form of a five-membered-fused six-membered compound as shown in formula I, a preparation method therefor, a pharmaceutical composition thereof, and a use thereof are disclosed. The crystal form and salt form of the compound have an inhibitory effect on FLT3 and/or IRAK4. The crystal form has a high single melt point, is thermodynamically stable, and has high crystallinity. The crystal form represents good physical and chemical stability under strong illumination, high temperature and high humidity conditions, and the crystal form has weak hygroscopicity.

Abstract: Provided are an ionizable lipid compound with an adjacent cis-double bond structure, a preparation method therefor, and the use thereof in the delivery of an active therapeutic agent (e.g., a nucleic acid). The ionizable lipid compound can provide a higher encapsulation rate of active substances and a better cell or in vivo transfection rate, and is particularly suitable for preparing nanoparticles with a solid structure.