Abstract: A radiation therapy treatment method includes providing a patient model, dosimetric constraints, delivery motion constraints, and delivery coordinate space of a radiation delivery device, where the delivery coordinate space is represented as a mesh with vertices connected by edges, where the vertices correspond to directions of a beam eye view (BEV) of the radiation delivery device. BEV region connectivity manifolds are constructed from the patient model, the dosimetric constraints, the delivery coordinate space, and existing beam trajectories, wherein each of the BEV region connectivity manifolds represents connections between contiguous 2D target regions. Beam trajectories are selected based on region connectedness information in the BEV region connectivity manifolds, the dosimetric constraints, the delivery motion constraints, and the existing beam trajectories. Radiation is delivered using the radiation delivery device in accordance with the selected beam trajectories.

Abstract: A method of operating an elevator system for a learn run sequence including the steps of moving, using a linear propulsion system, an elevator car through a lane of an elevator shaft at a selected velocity; detecting, using a sensor system, the location of the elevator car when it moves through the lane; controlling, using a control system, the elevator car, the control system being in operable communication with the elevator car, the linear propulsion system, and the sensor system; and determining, using the control system, a location of each of the car state sensors relative to each other within the lane in response to at least one of a travel time of the elevator car, a velocity of the elevator car, a position of the elevator car, and a height of the elevator car.

Abstract: A radiation therapy treatment method includes providing a patient model, dosimetric constraints, delivery motion constraints, and delivery coordinate space of a radiation delivery device, where the delivery coordinate space is represented as a mesh with vertices connected by edges, where the vertices correspond to directions of a beam eye view (BEV) of the radiation delivery device. BEV region connectivity manifolds are constructed from the patient model, the dosimetric constraints, the delivery coordinate space, and existing beam trajectories, wherein each of the BEV region connectivity manifolds represents connections between contiguous 2D target regions. Beam trajectories are selected based on region connectedness information in the BEV region connectivity manifolds, the dosimetric constraints, the delivery motion constraints, and the existing beam trajectories. Radiation is delivered using the radiation delivery device in accordance with the selected beam trajectories.

Abstract: The present disclosure describes a Mtu ?I-CM intein variant containing one or more mutations or a biologically active fragment thereof, and a method for producing and purifying a molecule of interest using the intein variant. Further described are isolated fusion proteins comprising the intein variant and a tag and a molecule of interest. Also described are expression systems for expressing the intein variant as well as polypeptide screening methods employing the intein variant.

Abstract: A ratio of reversible electroporation and irreversible electroporation may be controlled by selecting a symmetric waveform or asymmetric waveform to either minimize or enhance irreversible effects on cells in the target tissue. Combined reversible and irreversible electroporation includes inserting one or more therapeutic electrodes into a target tissue, introducing an electroporation compound into the target tissue, selecting a pulse waveform that is either 1) asymmetric bipolar that has positive and negative pulses with different durations, or 2) symmetric bipolar that has positive and negative pulses with the same duration, and delivering to the target tissue a series of electrical pulses having the selected pulse waveform.

Abstract: A treatment planning prediction method to predict a Dose-Volume Histogram (DVH) or Dose Distribution (DD) for patient data using a machine-learning computer framework is provided with the key inclusion of a Planning Target Volume (PTV) only treatment plan in the framework. A dosimetric parameter is used as an additional parameter to the framework and which is obtained from a prediction of the PTV-only treatment plan. The method outputs a Dose-Volume Histogram and/or a Dose Distribution for the patient including the prediction of the PTV-only treatment plan. The method alleviates the complicated process of quantifying anatomical features and harnesses directly the inherent correlation between the PTV-only plan and the clinical plan in the dose domain. The method provides a more robust and efficient solution to the important DVHs prediction problem in treatment planning and plan quality assurance.

Abstract: A ratio of reversible electroporation and irreversible electroporation may be controlled by selecting a symmetric waveform or asymmetric waveform to either minimize or enhance irreversible effects on cells in the target tissue. Combined reversible and irreversible electroporation includes inserting one or more therapeutic electrodes into a target tissue, introducing an electroporation compound into the target tissue, selecting a pulse waveform that is either 1) asymmetric bipolar that has positive and negative pulses with different durations, or 2) symmetric bipolar that has positive and negative pulses with the same duration, and delivering to the target tissue a series of electrical pulses having the selected pulse waveform.

Abstract: A radiation therapy treatment method includes providing a patient model, dosimetric constraints, delivery motion constraints, and delivery coordinate space of a radiation delivery device, where the delivery coordinate space is represented as a mesh with vertices connected by edges, where the vertices correspond to directions of a beam eye view (BEV) of the radiation delivery device. BEV region connectivity manifolds are constructed from the patient model, the dosimetric constraints, the delivery coordinate space, and existing beam trajectories, wherein each of the BEV region connectivity manifolds represents connections between contiguous 2D target regions. Beam trajectories are selected based on region connectedness information in the BEV region connectivity manifolds, the dosimetric constraints, the delivery motion constraints, and the existing beam trajectories. Radiation is delivered using the radiation delivery device in accordance with the selected beam trajectories.

Abstract: The present invention discloses amphiphilic nonsteroid anti-inflammatory platinum nanoparticles, preparation methods therefor and applications thereof. The amphiphilic nonsteroid anti-inflammatory platinum nanoparticle includes an amphiphilic complex formed by coordinating a nonsteroid anti-inflammatory drug and a platinum antitumor drug. Compared with other platinum drugs, the amphiphilic nonsteroid anti-inflammatory platinum prepared according to the present invention can self-assemble into a nanoparticle in an aqueous solution without the addition of an additive or a surfactant. The amphiphilic platinum complex can achieve targeted accumulation of tumor tissues by means of the enhanced permeability and retention effect of the tumor tissues, thereby reducing the side effects of platinum drugs.

Abstract: A manufacturing method of an OLED anode and display device are provided, which the former method comprises the steps: forming an anode-film layer, a material is an ITO, on a substrate; forming a photoresist-film layer on the anode-film layer; patterning the photoresist-film layer to acquire a photoresist-mask pattern, which comprises: an area of photoresist full-retention, photoresist half-retention, and a photoresist full-removal, wherein the photoresist area of half-retention is located between the full-retention and the full-removal; etching the anode film layer to acquire an anode pattern; removing the photoresist half-retention area; perform a plasma treatment to a portion of the anode pattern outside the photoresist full-retention area by adopting a first gas, comprising at least one of O2, N2O, CF4, Ar; removing the photoresist-mask pattern.

Abstract: The disclosure provides an OLED display device and a process for manufacturing the same, wherein the OLED display device includes a substrate, a first electrode, an organic functional layer, a second electrode, a polymer dispersed liquid crystal (PDLC) layer, and an upper electrode stacked in sequence, wherein the first electrode is an opaque electrode, and the second electrode is a semi-transparent electrode, and a micro-cavity structure consists of the first electrode, the organic functional layer, and the second electrode. The disclosure implements anti-peeping function and ensures the privacy of the display contents of the OLED display device while doing no harm to the organic functional layer. The disclosure also ensures that the display contents of the OLED display device can be dearly seen in a variety of angle.

Abstract: The disclosure provides an OLED display device and a process for manufacturing the same, wherein the OLED display device includes a substrate, a first electrode, an organic functional layer, a second electrode, a polymer dispersed liquid crystal (PDLC) layer, and an upper electrode stacked in sequence, wherein the first electrode is an opaque electrode, and the second electrode is a semi-transparent electrode, and a micro-cavity structure consists of the first electrode, the organic functional layer, and the second electrode. The disclosure implements anti-peeping function and ensures the privacy of the display contents of the OLED display device while doing no harm to the organic functional layer. The disclosure also ensures that the display contents of the OLED display device can be dearly seen in a variety of angle.

Abstract: A manufacturing method of an OLED anode and display device are provided, which the former method comprises the steps: forming an anode-film layer, a material is an ITO, on a substrate; forming a photoresist-film layer on the anode-film layer; patterning the photoresist-film layer to acquire a photoresist-mask pattern, which comprises: an area of photoresist full-retention, photoresist half-retention, and a photoresist full-removal, wherein the photoresist area of half-retention is located between the full-retention and the full-removal; etching the anode film layer to acquire an anode pattern; removing the photoresist half-retention area; perform a plasma treatment to a portion of the anode pattern outside the photoresist full-retention area by adopting a first gas, comprising at least one of O2, N2O, CF4, Ar; removing the photoresist-mask pattern.

Abstract: This invention describes methods to compute coronary physiology indexes using a high precision registration model, which consists of acquiring coronary angiography images of coronary vessels, performing intravascular imaging, and registering the coronary angiography images with intravascular images to create a high precision registration model, based upon which the coronary flow, fractional flow reserve (FFR) and index of microcirculation resistance (IMR) can be computed. The methods described in this invention to compute coronary flow, FFR, IMR are based on both coronary angiography and intravascular images, and the accuracy is better than those derived from coronary angiography alone or intravascular imaging alone, and have high practical values.

Abstract: A radiation therapy treatment method includes providing a patient model, dosimetric constraints, delivery motion constraints, and delivery coordinate space of a radiation delivery device, where the delivery coordinate space is represented as a mesh with vertices connected by edges, where the vertices correspond to directions of a beam eye view (BEV) of the radiation delivery device. BEV region connectivity manifolds are constructed from the patient model, the dosimetric constraints, the delivery coordinate space, and existing beam trajectories, wherein each of the BEV region connectivity manifolds represents connections between contiguous 2D target regions. Beam trajectories are selected based on region connectedness information in the BEV region connectivity manifolds, the dosimetric constraints, the delivery motion constraints, and the existing beam trajectories. Radiation is delivered using the radiation delivery device in accordance with the selected beam trajectories.

Abstract: The present application provides a display panel, including a first substrate, a liquid crystal layer, a second substrate, and a spacer. The liquid crystal layer is disposed between the first substrate and the second substrate, the spacer is used for supporting the first substrate and the second substrate, a positioning structure is disposed between the spacer and the second substrate, the positioning structure includes a groove, one end of the spacer is received in the groove, and the groove is used for positioning the spacer. The present application also provides a method for manufacturing a display panel.

Abstract: A sealant applying device and a working method thereof, and a sealant applying apparatus are disclosed. The sealant applying device includes a nozzle; the nozzle includes an air inlet portion and a sealant outflow portion, a switch plate is arranged below the sealant outflow portion, the switch plate includes a plate body configured to horizontally move between a first state and a second state, one end of the plate body is provided with a through hole, and a discharge portion is provided at a position corresponding to the through hole and on a side of the plate body facing away from the sealant outflow portion.

Abstract: A radiation therapy treatment method includes providing a patient model, dosimetric constraints, delivery motion constraints, and delivery coordinate space of a radiation delivery device, where the delivery coordinate space is represented as a mesh with vertices connected by edges, where the vertices correspond to directions of a beam eye view (BEV) of the radiation delivery device, where each BEV has corresponding area elements resulting from beam collimation. BEV region connectivity manifolds are constructed from the patient model, the dosimetric constraints, the delivery coordinate space, and existing beam trajectories, wherein each of the BEV region connectivity manifolds represents connections between contiguous 2D target regions, where each of the 2D target regions is defined at each of the vertices of the delivery coordinate space.

Abstract: The disclosure provides a liquid blade, the liquid blade includes water inlets, a water outlet and a waste storage groove, the water outlet is communicated with an upper section of the waste storage groove. Liquid enters the waste storage groove through the water inlets and draining through the water outlet. The liquid blade provided by the disclosure collects residue by the waste storage groove to prevent clogging of the water outlet of the liquid blade.

Abstract: A sealant applying device and a working method thereof, and a sealant applying apparatus are disclosed. The sealant applying device includes a nozzle: the nozzle includes an air inlet portion and a sealant outflow portion, a switch plate is arranged below the sealant outflow portion, the switch plate includes a plate body configured to horizontally move between a first state and a second state, one end of the plate body is provided with a through hole, and a discharge portion is provided at a position corresponding to the through hole and on a side of the plate body facing away from the sealant outflow portion.