Abstract: Methods for determining copy number for target genomic segments in a genome are described. The method may comprise, for example, obtaining a plurality of sequencing depth signals for a plurality of genomic segments, where a sequencing depth signal corresponds to a number of sequence reads aligned to a locus in a genomic segment, and where the plurality of genomic segments comprises a target genomic segment; determining a first, second, and third statistical moment for the plurality of genomic segments from the plurality of sequencing depth signals; determining a tumor purity and tumor ploidy for the sample from the first, second, and third statistical moment; and determining the copy number of the target genomic segment based on the sequencing depth signals for the target genomic segment, the tumor purity, and the tumor ploidy. The method may further comprise generating a genomic profile for the sample based on the determined copy number.

Abstract: A method of fabricating a space vehicle including a solar cell array panel, the method comprising: providing a plurality of multijunction solar cells; dispensing an uncured silicone coaling on each of the solar cells using an automated process with visual recognition; picking a cover glass from a cartridge stack and mounting the cover glass over the discrete respective solar cell to form a discrete Cell-Interconnect-Cover Glass (CIC) assembly; curing the silicone coating on each of the solar cells to mount it to the panel; and mounting the panel on the space vehicle.

Abstract: A method performed by an electronic apparatus, an electronic apparatus and a storage medium, which involves the field of artificial intelligence are provided. The method includes obtaining target sound masks of a target in a first video at respective moments, based on image-related information of the target, a first audio signal corresponding to the first video, and direction information of the first audio signal, and obtaining a second audio signal in which a sound related to the target is excluded, based on the target sound masks of the target at the respective moments and the first audio signal.

Abstract: The present disclosure provides a passivated contact solar cell and a photovoltaic module. The passivated contact solar cell includes a silicon substrate. The silicon substrate includes a first region and a third region spaced apart from each other on a back side thereof. In the first region, the back side of the silicon substrate is sequentially provided with a dielectric layer, a first doped layer, and a first passivation layer thereon. The dielectric layer and the first doped layer form a passivated contact structure in the first region. In the third region, the back side of the silicon substrate is also provided with the first passivation layer thereon. A second region is arranged between the first region and the third region. The second region is provided with a stepped structure having at least two steps.

Abstract: The present invention belongs to the field of molecular biology and genetics, and in particular relates to a method for editing a bovine gene based on Pro-iCHI. The present invention provides a method for editing a bovine gene based on Pro-iCHI. Protamine is transiently expressed in gene-edited b-haSCs, which are then injected to mature oocytes to obtain reconstructed embryos. Protamine can eliminate abnormal DNA methylation resulting from oocyte intracytoplasmic haSCs injection and enable the nucli to compress into sperm-like structures, and the obtained bovine Pro-iCHI embryos can successfully develop into blastocysts, with a blastocyst rate comparable to that of the embryos obtained by in vitro fertilization. Moreover, in the present invention, a protamine-encoding gene is inserted into a Saccharomyces cerevisiae protein expression vector for transient expression, which ensures that abnormal DNA methylation is erased, without integration into the genome resulting in the insertion of exogenous genes.

Abstract: A method of erasing an abnormal epigenetic modification in a sheep iCHI embryo and use thereof. A method including the steps of: transferring a recombinant plasmid expressing protamine into a sheep androgenetic haploid embryonic stem cell, then introducing the cell into a mature sheep oocyte, and performing activation and culture to obtain a sheep iCHI embryo without abnormal epigenetic modifications. In the present disclosure, abnormal methylations in iCHI embryos may be erased by transient expression of protamine in o-haSCs. The blastocyst rate of the prepared Pro-iCHI embryos is significantly higher than that of iCHI embryos, and is similar to that of IVF embryos. The resulting embryos can be used for embryo transfer to obtain semi-cloned gene-edited sheep, providing materials for subsequent breeding applications.

Abstract: Provided is a bovinized CRISPRboCas9 gene editing system, comprising a boCas9 protein and sgRNA. The mucleotide sequence encoding the boCas9 protein is as shown in SEQ ID NO. 1. Further provided are a bovinized CRISPRboCas9 gene editing method, and the use. SEQ ID NO. 1 is obtained by means of optimizing an exogenous Cas9 gene according to the codon preference of bovine cells, so that the transcription and translation efficiency of the Cas9 gene in bovine cells can be significantly improved, and the content of Cas9 protein in the cells is finally increased. Results show that the expression level of the modified bovinized boCas9 protein is twice that of a wild-type control group Cas9, and the target gene cleavage efficiency is at least 6 times that of a wild-type control group.

Abstract: The present application provides a speaker, which comprises a housing as well as a magnetic circuit system and a vibration system arranged the housing, the vibration system comprises a planar first voice coil which can generate mechanical motion under the action of a magnetic field of the magnetic circuit system, a planar first vibration diaphragm driven by the first voice coil, and the first voice coil is arranged on the first vibration diaphragm; the magnetic circuit system comprises a plurality of magnets, a gap is formed between the magnets, and at least a portion of the first voice coil corresponds to the gap between the magnets. The present speaker is different from a conventional moving-coil type speaker, and the speaker can be made smaller than a conventional moving-coil type speaker and with respect to high frequency performance, the speaker has higher sound pressure and a better bandwidth.

Abstract: A structured light system includes a camera module and a dot projection module. The dot projection module includes a submount, an emitter array disposed on the submount, and a diffractive optical element (DOE) disposed over the emitter array. The emitter array includes a plurality of emitters arranged in a periodic emitter pattern and the emitter array is oriented at a non-zero angle relative to a rectilinear axis of the submount.

Abstract: A method for manufacturing a semiconductor structure includes: a base provided with a contact hole is provided; an initial contact structure including a first diffusion barrier layer, a conductive layer and a second diffusion barrier layer stacked onto one another is formed on the base, the first diffusion barrier layer conformably covering the contact hole and covering part of a top surface of the base, the conductive layer covering first diffusion barrier layer and being filled in unoccupied space in the contact hole, the second diffusion barrier layer covering a side of the conductive layer away from first diffusion barrier layer, the initial contact structure outside the contact hole being provided with a groove exposing side walls of conductive layer and second diffusion barrier layer; a third diffusion barrier layer is formed on a side wall of initial contact structure exposed by the groove to obtain a target contact structure.

Abstract: The present application relates to the technical field of organic electroluminescent materials. Provided are an organic compound, an organic electroluminescent device and an electronic device. The organic compound provided by the present application has a structure as represented by Formula 1, and can significantly improve the performance of a device.

Abstract: The present application relates to the technical field of organic electroluminescent materials, and provides an organic compound, an organic electroluminescent device and an electronic apparatus. The organic compound of the present application has a structure shown in Formula 1 and can significantly improve the performance of the device.

Abstract: A method for suppressing a direct current-link (DC-Link) capacitor current ripple (CCR) of a coupled three-level inverter (TLI), including: dividing space vector diagram regions of coupled TLI based on value range of virtual voltage vector duty cycle distribution factor; determining, based on amplitude, phase angle, and three-phase output current of reference voltage vector, sector and region in which reference voltage vector is located; then selecting nearest one virtual voltage vector and two basic voltage vectors, to calculate duty cycles thereof, respectively; designing a controller, updating duty cycle distribution factor of small vector based on sector and region in which reference voltage vector is located, set value of voltage difference across DC-Link capacitors, and actual value of voltage difference across DC-Link capacitors; and designing switching sequence based on updated small vector duty cycle and sector and region in which reference voltage vector is located.

Abstract: A fiber-optic transmission-based real-time ocean bottom seismic node includes: a seismic acquisition compartment and a battery compartment, where the seismic acquisition compartment includes a seismometer compartment body, a compressed O-ring, and a seismometer compartment sealing cover; an airtight space is formed inside the seismometer compartment body by the seismometer compartment sealing cover via the compressed O-ring; a bottom of the seismometer compartment body is provided with a three-component seismometer for acquiring ocean bottom seismic data, and a top of the seismometer compartment body is provided with an optical-electrical conversion connector; the three-component seismometer communicates with a fiber-optic trunk cable of a user terminal via the optical-electrical conversion connector; and the battery compartment is detachably connected to the seismic acquisition compartment and configured to supply power to the three-component seismometer.

Abstract: A method for preparing a flexible sol-gel polishing block, the method comprises: (1) adding a gel agent and a 20 ?m diamond abrasive into deionized water, and stirring to even to obtain a first material; (2) adding carbon fiber into the first material obtained in the step 1, and mixing to even to obtain a second material; (3) injecting the second material obtained in the step 2 into a mold, and curing to obtain a cured gel; and (4) drying the cured gel to obtain the flexible sol-gel polishing block.

Abstract: A method for measuring a liquid flow property is provided.

Abstract: Apparatuses, systems, and techniques are presented to generate images. In at least one embodiment, one or more neural networks are used to generate one or more images using one or more pixel weights determined based, at least in part, on one or more sub-pixel offset values.

Abstract: Apparatuses, systems, and techniques are presented to generate images. In at least one embodiment, one or more neural networks are used to generate one or more images using one or more pixel weights determined based, at least in part, on one or more sub-pixel offset values.