Abstract: Disclosed in the present invention is an antibody-drug conjugate of a novel Exatecan analogue, a pharmaceutical composition containing the conjugate, and a medical use of the conjugate and the pharmaceutical composition. The novel Exatecan analogue of the present invention has very strong tumour inhibition efficiency, and the provided TROP-2 antibody-drug conjugate and HER3 antibody-drug conjugate have good tumour inhibition effects and good prospects for clinical application.

Abstract: The present disclosure discloses a continuous stirring transmission mechanism for tempering furnace workpiece transmission, including a heat treatment furnace body and a furnace body support, the heat treatment furnace body is fixed to the furnace body support, the heat treatment furnace body includes a furnace body shell, a heat preservation and insulation system and a heating system, the heating system supplies heat to the heat treatment furnace body; the mechanism further includes a driving mechanism and continuous stirring rotating rod assemblies. The continuous stirring transmission mechanism is provide for tempering furnace workpiece transmission; the problems of non-uniform heating of metal workpieces in the tempering process can be solved, and a heat utilization rate is improved.

Abstract: The present application discloses a method for preparing ferric phosphate, including the following steps: mixing a surfactant with a first metal liquid containing iron and phosphorus elements, adding with adding seed crystal, aging under heating and stirring, filtering the aged solution to obtain a filter residue, and drying and sintering the filter residue, thereby obtaining the ferric phosphate; the seed crystal is ferric phosphate dihydrate or basic ammonium ferric phosphate. In the present application, the surfactant is used for modification of the seed crystal, secondary crystal nucleus is generated, which induces the formation of the basic framework of the product particles. Through the aging process, the deposition of the crystal nucleus on the surface of the seed crystal makes the framework of the crystal grain more complete, so that the primary particles are arranged more densely and orderly and tend to constitute spherical secondary particles.

Abstract: Method for confirming ownership of digital assets based on hash algorithm and method for tracing to a source of digital assets based on hash algorithm are provided. Entities involved in confirming the ownership of digital assets include an original user, a CA authentication center and a digital asset authentication center. The process of confirming the ownership includes generating a one-time CA certificate by the original user, authenticating the digital assets by the digital asset authorization center and the original user, generating an ownership confirming document by the original user, creating a quantum digital signature by a three-party, and the like. The method for tracing includes generating subsidiary documents in real time, constructing a unique identity for a digital asset at an accessing moment, traceability analysis, and so on.

Abstract: The disclosure provides a hybrid light source system, the hybrid light source system includes a first light source group, a second light source group, and a bandpass filter. The first light source group and the second light source group emit light beams which are the same in color and different in wavelength range. An emergent direction of a light beam of the first light source group and an emergent direction of a light beam of the second light source group are perpendicular to each other. The bandpass filter is arranged on emergent light paths of the first light source group and the second light source group, an angle of 45 degrees is formed between the emergent direction of the light beam of the first light source group and the bandpass filter.

Abstract: The present disclosure provides an image-forming apparatus and a phase match method of photosensitive parts. The image-forming apparatus includes a first motor, configured to rotate a first photosensitive part; a second motor, configured to rotate a second photosensitive part; a first phase sensor, configured to detect a first rotation phase of the first photosensitive part; a second phase sensor, configured to detect a second rotation phase of the second photosensitive part; and a control unit, configured to, after at least one page of image-forming job is received and at least one of the first motor and the second motor receives a phase match instruction, perform phase match on the first photosensitive part and the second photosensitive part according to a rotation phase of a photosensitive part corresponding to a motor receiving the phase match instruction.

Abstract: The present application relates to the field of projection technology and discloses a phosphor wheel, a light source module, and a projector. A phosphor wheel includes a base, a first phosphor layer, and a second phosphor layer. The base includes an excitation light reflecting section and an excitation light transmitting section. The first phosphor layer is disposed on a surface of the excitation light reflecting section facing a direction of incident light and spreading along a circumferential direction of the base. The second phosphor layer is disposed on a surface of the excitation light transmitting section facing away from the direction of incident light and spreading along a circumferential direction of the base. The first phosphor layer and the second phosphor layer are offset to each other in a radial direction of the base.

Abstract: The invention belongs to the technical field of metal ceramics, in particular to a metal ceramic and a preparation method thereof. The hard phase is formed by at least four kinds of crystal grains with different compositions and shapes; and in the scanning electron microscope photograph of the metal ceramic, it can be observed the first hard phase comprising black titanium nitrocarbide, a thin ring and a thick ring wherein the core phase is pure black; the second hard phase in the form of a dark gray core-ring structure particles; the third hard phase in the form of a high-brightness white core-gray ring; and the fourth hard phase in the form of a homogenous gray phase and off-white core-gray ring structure particles. In addition, a white binder phase can also be observed, and the binder phase is at least one of cobalt and nickel.

Abstract: The present application relates to the field of projection technology and discloses a phosphor wheel, a light source module, and a projector. A phosphor wheel includes a base, a first phosphor layer, and a second phosphor layer. The base includes an excitation light reflecting section and an excitation light transmitting section. The first phosphor layer is disposed on a surface of the excitation light reflecting section facing a direction of incident light and spreading along a circumferential direction of the base. The second phosphor layer is disposed on a surface of the excitation light transmitting section facing away from the direction of incident light and spreading along a circumferential direction of the base. The first phosphor layer and the second phosphor layer are offset to each other in a radial direction of the base.

Abstract: A flurbiprofen axetil emulsion for injection can be prepared by specific stepwise addition of an oil phase to a water phase with shear mixing under the protection of nitrogen gas to obtain an emulsion. The oil phase includes flurbiprofen axetil, an oil phase solvent, an emulsifier, and a stabilizer, and the water phase includes water for injection and/or an osmotic pressure regulator. In the presence of a stabilizer in the oil phase, the emulsion can improve the emulsification effect by using the stepwise emulsifying technique for the oil phase, so that the obtained flurbiprofen axetil emulsion for injection has more uniform particle size, higher drug entrapment efficiency, and better targeting of the drug to the wounded tissue.

Abstract: The embodiments of the disclosure disclose a method for establishing an association of a multi-link device, a electronic device, and a storage medium.

Abstract: Disclosed is a non-coaxial projection light source system including a light source, a fluorescent wheel, and a converging shaping lens group located between the light source and the fluorescent wheel. Excitation light emitted by the light source is emitted to the converging shaping lens group in an optical axis direction inclined to the converging shaping lens group and then is emitted to the fluorescent wheel. Radiating fluorescent light generated by excitation on the fluorescent wheel is emitted to the converging shaping lens group and then is converged to a light path direction different from the excitation light to be output.

Abstract: A medicine bottle for separately containing, preparing, and delivering solid and liquid medicine includes a bottle body, a first sealing separator, a second sealing separator, a sliding penetration rod, and a protective structure. The first sealing separator and the second sealing separator are separately sealed and arranged inside the bottle body to separate a compartment of the bottle body into upper, middle, and lower chambers. The sliding penetration rod is arranged inside the upper chamber of the bottle body as a cylinder in clearance fit with an inner wall of the bottle body, forming piston-like connection allowing for relative sliding. The sliding penetration rod has a through hole inside and a length greater than a sum of lengths of the upper and lower chambers of the bottle body. The protective structure is cup-shaped and fastened upside-down on a top of the bottle body to protect the sliding penetration rod.

Abstract: Methods and wearable devices for optimizing power consumption using sensor-based position and use determinations are described here. One example method is performed at a device that includes a first sensor configured to operate with a first power consumption rate and a second sensor configured to operate with a second power consumption rate. The method includes, while a component associated with the second sensor is in an inactive state, receiving first sensor data, and determining whether the first sensor data indicates movement of the device. The method also includes, when movement of the device is indicated, operating the second sensor in an active state. The method further includes, after activating the second sensor, when second sensor data from the second sensor indicates that the device has been placed on a user’s body, continuing to operate the second sensor in the active state.

Abstract: A specification for a semi-conductor chip is received. The specification specifies a set of photomasks associated with a metal layer of the semi-conductor chip. Multiple portions of an area of the metal layer are identified. A respective image is generated for each portion of the area based on the photomasks. A respective drawn density of metal wires for each portion of the area is calculated. A trained machine learning model is invoked to predict a respective silicon density of metal wires for each respective portion of the area based on an image and a drawn density for the respective portion of the area. A silicon density for the area of the metal layer is calculated based on a combination of predicted silicon densities for the multiple portions of the area. The combination is based on an average value of the predicted silicon densities for the multiple portions of the area.

Abstract: The embodiments disclosed herein provide compounds as shown in formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, a deuterated compound, a prodrug or a mixture thereof, or a pharmaceutically acceptable salt or solvate of the compounds as shown in formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, a deuterated compound, a prodrug or a mixture thereof, wherein R1 to R7 are as defined in the description. This application also provides a preparation method and a medical use of the compounds. The compounds of this disclosure have an activity superior or equivalent to the candidate drug LY2835219 currently under phase III clinical trial, and some of the compounds exhibit better selectivity. Moreover, the preferred compounds exhibit good absorption and good blood-brain distribution when administered orally.

Abstract: Disclosed are a method and apparatus for controlling a multi-link device to transmit data, a device and a storage medium. The method comprises: a first multi-link device transmitting a data packet to a second multi-link device via a first link, the data packet indicating that the second multi-link device is required to assist in transmitting data on a second link; receiving a first message which is for assisted transmission and is transmitted by the second multi-link device via the second link; transmitting a second message responding to the first message to the second multi-link device via the second link; and transmitting data via the second link within the transmission duration allocated to the first multi-link device on the second link.

Abstract: Disclosed are a method and apparatus for transmitting system parameters of a soft access device, a device and a medium. A method for acquiring system parameters of a soft access device includes: receiving a broadcast message sent by the soft access device on a main link, a reduced neighbor report information element in the broadcast message including a multi-link device identifier, an identifier of a non-main link and a system parameter change count; sending a first message for requesting system parameters on the non-main link to the soft access device on the main link in a case that the received broadcast message indicates that a value of a system parameter change count corresponding to the non-main link is different from that of a system parameter change count received last time; and receiving a second message in response to the first message and sent by the soft access device on the main link.

Abstract: A light source system, comprising a first light source, a first wavelength conversion device, a second wavelength conversion device, a light path conversion element, and a light combining unit. The light path conversion element is configured to make an excitation light emitted by the first light source irradiate the first wavelength conversion device and the second wavelength conversion device in turn, so as to correspondingly excite and generate a first excited light and a second excited light. The light combining unit is configured to combine the first excited light and the second excited light. A projector system, comprising the light source system.

Abstract: The disclosure provides a hybrid light source system, the hybrid light source system includes a first light source group, a second light source group, and a bandpass filter. The first light source group and the second light source group emit light beams which are the same in color and different in wavelength range. An emergent direction of a light beam of the first light source group and an emergent direction of a light beam of the second light source group are perpendicular to each other. The bandpass filter is arranged on emergent light paths of the first light source group and the second light source group, an angle of 45 degrees is formed between the emergent direction of the light beam of the first light source group and the bandpass filter.