Abstract: An FGFR4 inhibitor acid salt, a preparation method therefor, and a use thereof are provided. The FGFR4 inhibitor is a compound N-((3S,4S)-3-((6-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(3-methoxy-3-methylazetidin-1-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide having the structure represented by formula (I), and the acid salt is p-toluenesulfonate. The physical and chemical properties such as the solubility and bioavailability of the compound represented by formula (I) in the free form are greatly increased, and the development requirements of clinical medicine preparations can be met. The FGFR4 inhibitor has vital clinical application value for p-toluenesulfonate and has the prospect of developing into a new generation of FGFR4 small-molecule inhibitors.

Abstract: The present invention discloses an intelligent ward round method and system based on an SSVEP electroencephalogram signal, the method including: the interactive terminal is used to present a visual stimulus source that includes a plurality of candidate intention options to the patient, the acquisition terminal is used to collect the patient's electroencephalogram signal, the electroencephalogram signal obtained by the acquisition terminal is transmitted to the interactive terminal for electroencephalogram signal recognition, the patient's expression intention is determined, and the expression intentions comprise disease intentions, privacy intentions, psychological intentions, physiological intentions, environmental intentions, and safety intentions, and the intelligent ward round is completed. This method greatly improving the ability of communication between the patient and medical staff.

Abstract: A simplified method and system for denoising an infrared image by using non-local means (NLMeans) based on a field programmable gate array (FPGA), a medium, and a device are provided. The method includes: step S1: determining a size of a search window and a size of a matching window; step S2: performing linear superposition on a Manhattan distance and a Chebyshev distance to calculate a similarity between each matching block and a central block; and step S3: calculating a weight of each matching block based on the similarity, and calculating a current denoising result based on each matching block and the corresponding weight. The method can basically maintain a noise denoising effect of original NLMeans, and enable the NLMeans to be easily implemented on an FPGA.

Abstract: An exhaust pipe, a method for optimizing and designing an exhaust pipe, and an engine are provided. The exhaust pipe includes a first exhaust pipeline arranged in a first direction, an EGR pipeline arranged in a second direction, and a pre-turbine pipeline arranged in a third direction. An input end of the EGR pipeline is communicated with an output end of the first exhaust pipeline, and an included angle ?1 between the first direction and the second direction is smaller than 60°. The pre-turbine pipeline, the EGR pipeline and the first exhaust pipeline are located in a first plane; the pre-turbine pipeline is communicated with the EGR pipeline, an included angle ?2 between the third direction and the second direction is smaller than or equal to 90°, and a cross-sectional diameter D of the pre-turbine pipeline is 0.2-1 times the diameter H of the first exhaust pipeline.

Abstract: A loudspeaker device includes a speaker component, a first microphone element, and a second microphone element. The speaker component includes an earphone core and a core housing. The first microphone element is disposed on a first branch circuit board of a circuit board. The second microphone element is disposed on a second branch circuit board of the circuit board. The circuit board is configured to electrically connect to an audio signal wire, a first auxiliary signal wire, and a second auxiliary signal wire of an external control circuit. The audio signal wire, the first auxiliary signal wire, and the second auxiliary signal wire are electrically and respectively connected to the earphone core, the first microphone element, and the second microphone element through the circuit board. A board surface of the second branch circuit board is tilt with respect to a board surface of the first branch circuit board.

Abstract: The present disclosure discloses an earphone. The earphone may include a hook-shaped component, a connecting component, and a holding component. When the earphone is in a wearing state, the hook-shaped component may be configured to hang between a rear side of an ear of a user and a head of the user. The holding component may be configured to contact a front side of the ear. The connecting component may be configured to connect the hook-shaped component and the holding component and extend from the head to an outside of the head to cooperate with the hook-shaped component to provide the holding component with a pressing force on the front side of the ear.

Abstract: A wireless communication method and apparatus and a communication system. The wireless communication method includes: a terminal equipment receives an indication information set; and the terminal equipment determines a priority of a first uplink signal according to the indication information set, the first uplink signal being an uplink signal used for beam failure recovery.

Abstract: Described herein are compounds represented by formulas (IA) or (IB) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables R1, R3, R4, Y1, Y2, Ar, Z and n are as defined herein.

Abstract: An automatic support device for resisting rock burst in mines is provided, which includes bases symmetrically distributed, sliding frames are slidably connected to the bases, hydraulic rods are fixedly connected to the bases, and telescopic ends of the hydraulic rods are fixedly connected to the adjacent sliding frames. The sliding frames are fixedly connected to brackets, and the brackets symmetrically distributed are provided with a main support plate, on which pushing rods are provided. The device can slow down the impact force of the device when rock burst occurs in the mine, at the same time, it plays a supporting role in the mine, ensuring the stability of the roof of the mine.

Abstract: A panoramic system can receive content (e.g., live video) recorded in a landscape orientation and use a portrait dynamic crop window to display a portrait area of the received content. The panoramic system can further display the content in a landscape dynamic crop window that has a moveable user interface control that can pan the portrait crop window as the content plays in one or both of the dynamic crop windows.

Abstract: The embodiments of the present disclosure disclose an acoustic apparatus. The acoustic apparatus may include a support assembly. The support assembly may include a first portion and a second portion. When a user is wearing the acoustic apparatus, the first portion may be hung between a first side of an ear and a head of the user, the second portion may contact a second side of the ear. The first portion may cause the second portion to provide a compressive force on the second side of the ear.

Abstract: The embodiments of the present disclosure provide a method and an Internet of Things (IoT) system for determining a purification parameter of gas in a storage and distribution station. The IoT system includes a smart gas user platform, a smart gas service platform, a smart gas device management platform, a smart gas sensor network platform, and a smart gas object platform. The method is executed by a processor of the smart gas device management platform. The method includes: predicting at least one group of recommended operation parameters and at least one effect score corresponding to the at least one group of recommended operation parameters through a recommended operation parameter prediction model; determining an operation parameter in a purification process; and generating a remote control instruction and sending the remote control instruction to the smart gas object platform for performing a purification operation of the raw gas.

Abstract: Disclosed are a method and a system for safety monitoring of a gas pipe well based on a smart gas IoT. The method may include: obtaining an environmental information sequence of the gas pipe well and an in-well monitoring data sequence by controlling a monitoring component according to a monitoring parameter based on the smart gas IoT, and storing the environmental information sequence and the in-well monitoring data sequence in a storage unit; determining an in-well risk value; adjusting the monitoring parameter in response to determining that the in-well risk value exceeds a risk threshold and updating the in-well risk value; determining weatherability of a gas component; determining an impact degree of the gas component; determining a pipe well inspection program and generating a corresponding pipe well inspection instruction to be sent to an inspection terminal; and adjusting the monitoring parameter and clearing expired data in the storage unit.

Abstract: The present disclosure provides an acoustic output device. The acoustic output device may comprise a bone conduction speaker configured to generate bone conduction acoustic waves. The acoustic output device may also comprise an air conduction speaker configured to generate air conduction acoustic waves, the air conduction speaker being independent of the bone conduction speaker. The acoustic output device may further comprise at least one housing configured to accommodate the bone conduction speaker and the air conduction speaker.

Abstract: The present disclosure provides a sound output device, a sensory sound source adjustment method, and a volume adjustment method. The sound output device includes: a signal processing circuit to generate, during operation, a first electrical signal and a second electrical signal based on target sound information; a first speaker, electrically connected to the signal processing circuit to receive, during operation, the first electrical signal from the signal processing circuit and convert the first electrical signal into a first excitation to excite a first mechanical structure to generate a first sound wave; and a second speaker, electrically connected to the signal processing circuit to receive, during operation, the second electrical signal from the signal processing circuit and convert the second electrical signal into a second excitation to excite a second mechanical structure to generate a second sound wave.

Abstract: The present disclosure provides an acoustic device. The acoustic device may include a shell including a first accommodation cavity, a speaker configured in the first accommodation cavity. The speaker may include one or more magnetic circuit assemblies, a voice coil, a vibration assembly, and a vibration transmission plate. The one or more magnetic circuit assemblies may form a magnetic gap. One end of the voice coil may be arranged in a magnetic gap, and another end of the voice coil may be connected with the vibration assembly. The vibration assembly may be connected with the vibration transmission plate, and the vibration transmission plate may be connected with the shell.

Abstract: The present disclosure provides an Industrial Internet of Things system for monitoring a collaborative robot with dual identification and a control method thereof. The Industrial Internet of Things includes a user platform, a service platform, a management platform and a sensing network platform and an object platform connected in sequence, and the control method comprises: monitoring a target collaborative robot on a production line, obtaining monitoring data, the monitoring data including at least one of image information of the target collaborative robot and displacement sensor data of the target collaborative robot; and processing the monitoring data.

Abstract: The present application relates to a biochemical reaction test tube and a use method thereof, and a gene amplification kit. The biochemical reaction test tube includes a tube portion and a cover portion. The tube portion includes: a tube body including a first chamber and a second chamber, where a bottom of the second chamber is spaced apart from a bottom of the first chamber; and a limit unit provided at an outer side of the tube body. The first chamber and the second chamber are provided at different heights and used to hold different reaction components and solutions. Only one of the first chamber and the second chamber is heated to complete a biochemical reaction. When the test tube is vertically flipped at 180° and shaken, the solutions in the first chamber and the second chamber are mixed to further achieve a reaction, which eliminates harmful results.

Abstract: A lighting apparatus includes a light source, a bottom tray, an optical plate and a waterproof adhesive tape. The light source is placed upon the bottom plate. The bottom tray has a bottom plate, a lateral wall and a folded structure. The lateral wall defines a light opening. The folded structure is disposed at a top edge of the lateral wall. An optical plate is placed to cover the light opening to change a light parameter of a light emitted from the light source. At least a portion of a waterproof adhesive tape and a peripheral edge of the optical plate are stacked together to be fastened by the folded structure of the bottom tray.

Abstract: The present disclosure provides a method for power consumption analysis and troubleshooting of a production line based on an Industrial Internet of Things, system, and storage medium thereof.